GEO DataSets

(Submitter supplied) Nr4a1 deficient rats (Nr4a1-/-) were developed using the fawn hooded hypertensive rat (FHH), which provided a genetic background susceptible to kidney injury. Both groups of animals were evaluated for blood pressure, proteinuria, renal function, and whole transcriptome gene pathway changes. Gene expression profiling was performed at week 8, 16, and 24 using kidney from FHH and Nr4a1-/- rats. To identify differentially expressed gene between FHH and Nr4a1-/- two statistical methods were utilized: (1) FWER (family-wise error rate) procedure, p<0.05 and fold-change ±1.2 or greater; and/or (2) Benjamani and Hochberg FDR (false discovery rate) using p<0.05, and fold-change ±1.2 or greater. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS5223

Platform:

GPL6247

18 Samples

Download data: CEL, CHP

Analysis of kidney from 8-24 week-old, Nr4a1-deficient (Nr4a1−/−) animals developed on the genetic background of the Fawn-Hooded Hypertensive (FHH) rat. The FHH model is susceptible to kidney injury. Results provide insight into the role of Nr4a1 in the pathogenesis of kidney disease.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 genotype/variation, 3 time sets

Platform:

GPL6247

Series:

GSE54714

18 Samples

Download data: CEL, CHP

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html #%create_date=Wed Mar 11 16:20:04 2009 PDT #%chip_type=RaGene-1_0-st-v1 #%lib_set_name=RaGene-1_0-st #%lib_set_version=v1 #%genome-species=Rattus norvegicus #%genome-version=rn4 #%genome-version-ucsc=rn4 #%genome-version-ncbi=HGSC v3.4 #%genome-version-create_date=2004-11 #%netaffx-annotation-date=2009-03-16 #%netaffx-annotation-netaffx-build=28 Protocol: See manufacturer's web site

Organism:

Rattus norvegicus

13 DataSets

197 Series

3 Related Platforms

3283 Samples

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