GEO DataSets

(Submitter supplied) Identification of BRD32048 as an inhibitor of ETV1 oncogenic transcription factor. This compound was indentified by small molecule mcroarray (a binding assay). It was able to consistently inhibit an ETV1-dependent MMP1-driven luciferase signal. Its direct binding was validated by Suface plasmon resonance (Biacore assay). It inhibits ETV1-driven invasion in ETV1-dependent cell lines. The goal of this gene expression comparison was to interogate the effects of BRD32048 on the global gene expression and to define the degree to which its siganture overlaps with an ETV1-specific shRNA-induced gene expression signature.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17897

33 Samples

Download data: CEL

(Submitter supplied) Identical to GPL3921 but used a custom CDF Protocol: see manufacturer's web site

Organism:

Homo sapiens

1 Series

1 Related Platform

33 Samples

Download data: CDF, TXT