GEO DataSets

(Submitter supplied) In this dose series pregnant CD-1 (outbred) dams were exposed to the 2-chloro analogue of 2'-deoxyadenosine (a metabolic toxin) on 8 d.p.c. Test doses were developed from a teratological series for 2CdA-induced microphthalmia using BMDS modeling software from the US EPA. Benchmark doses for microarray analysis were: 5.0 mg/kg (25% risk), 2.5 mg/kg (5% risk), 1.25 mg/kg (NOAEL), and 0.625 mg/kg (subNOAEL). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS630

Platform:

GPL560

8 Samples

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Dose response analysis of ocular teratogen 2-chloro-2'deoxyadenosine (2CdA) exposure and induction of microphthalmia (small eye syndrome). Pregnant 8 days post coitum CD-1 dams exposed to 5, 2.5, 1.25 or 0.625 mg/kg 2CdA, and embryos examined at 3 hours.

Organism:

Mus musculus

Type:

Expression profiling by array, log ratio, 4 dose sets

Platform:

GPL560

Series:

GSE1068

8 Samples

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(Submitter supplied) Developmental Toxicity of the Mouse Embryo (DTME) includes expression data from early embryos at risk for teratogen-induced eye malformations. Early mouse embryos were exposed to various teratogens during neurulation stages with the aim of correlating large-scale changes in gene expression with a generic histopathological biomarker (p53 protein induction) across the critical period during exposure, and with the risk of malformations in term fetuses (the various exposure scenarios produce ~10% risk of malformations in term fetuses averaged across 50 conditions of the experiment). more...

Organism:

Mus musculus

6 DataSets

10 Series

96 Samples

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