GEO DataSets

(Submitter supplied) Two-year rodent bioassays play a central role in evaluating both the carcinogenic potential of a chemical and generating quantitative information on the dose-response behavior for chemical risk assessments. The bioassays involved are expensive and time-consuming, requiring nearly lifetime exposures (two years) in mice and rats and costing $2 to $4 million per chemical. Since there are approximately 80,000 chemicals registered for commercial use in the United States and 2,000 more are added each year, applying animal bioassays to all chemicals of concern is clearly impossible. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2497

Platform:

GPL1261

18 Samples

Download data: CEL

Analysis of livers of B6C3F1 females 13 weeks following treatment with chemicals that test positive in two-year rodent cancer bioassays. Results provide insight into the feasibility of using expression signatures, as alternatives to standard two-year bioassays, to identify chemical carcinogens.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 6 agent, 3 other sets

Platform:

GPL1261

Series:

GSE5128

18 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...

Organism:

Mus musculus

601 DataSets

4547 Series

40 Related Platforms

58950 Samples

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