GSM1132091[Accession] - GEO DataSets

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Items: 4

Select item 2000465451.

The Histone H3 Lysine 9 Methyltransferases G9a and GLP Regulate Polycomb Repressive Complex 2-Mediated Gene Silencing

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL17103 GPL13112
26 Samples

Download data: BED, CEL

Series

Accession:: GSE46545

ID:: 200046545

Select item 2000465442.

The Histone H3 Lysine 9 Methyltransferases G9a and GLP Regulate Polycomb Repressive Complex 2-Mediated Gene Silencing [Affymetrix]

(Submitter supplied) G9a/GLP and Polycomb Repressive Complex 2 (PRC2) are two major epigenetic silencing machineries, which in particular methylate histone H3 on lysines 9 and 27 (H3K9 and H3K27), respectively. Although evidence of a crosstalk between H3K9 and H3K27 methylations has started to emerge, their actual interplay remains elusive. Here, we show that PRC2 and G9a/GLP interact physically and functionally. Moreover, combining different genome-wide approaches, we demonstrate that Ezh2 and G9a/GLP share an important number of common genomic targets, encoding developmental and neuronal regulators. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL17103
12 Samples

Download data: CEL

Series

Accession:: GSE46544

ID:: 200046544

Select item 1000171033.

[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [CDF: MoGene10stv1_Mm_ENSG version 15]

(Submitter supplied) This is identical to GPL6246 but a custom cdf environment was used to extract data. The custom CDF file is based on Ensembl genes (from http://brainarray.mbni.med.umich.edu version 15). The custom cdf is linked below as a supplementary file.