GSM1126201[Accession] - GEO DataSets

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Items: 4

Select item 2000462031.

Transcriptional effects of CTGF inhibition and gemcitabine in the KPC mouse model of pancreatic ductal adenocarcinoma

(Submitter supplied) Pancreatic ductal adenocarcinoma (PDA) is characterized by abundant desmoplasia and poor tissue perfusion. These features are proposed to limit access of therapies to neoplastic cells and blunt treatment efficacy. Indeed, several agents that target the PDA microenvironment promote chemotherapy delivery and improve anti-neoplastic responses in murine models of PDA. Here, we employed the FG-3019 monoclonal antibody directed against the pleiotropic matricellular signaling molecule connective tissue growth factor (CTGF/CCN2). more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4945
Platform:: GPL8321
24 Samples

Download data: CEL

Series

Accession:: GSE46203

ID:: 200046203

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 49452.

FG-3019/gemcitabine combined-treatment effect on KPC model of pancreatic ductal adenocarcinoma

Analysis of PDA tumors isolated from KPC (LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre) mice after combined treatment with FG-3019 (a mAb directed against CTGF) and chemotherapy drug gemcitabine. Results provide insight into the molecular basis of the enhanced anti-PDA activity of FG-3019/gemcitabine.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 4 protocol sets

Platform:: GPL8321
Series:: GSE46203
24 Samples

Download data: CEL

DataSet

Accession:: GDS4945

ID:: 4945

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 1000083213.

[Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 08, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The GeneChip Mouse Genome 430A 2.0 Array is a single array representing approximately 14,000 well-characterized mouse genes that can be used to explore biology and disease processes. more...