GSM112489[Accession] - GEO DataSets

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Items: 4

Select item 2000049901.

Expression profile between mast cells from diabetic prone and diabetic resistant rat strains

(Submitter supplied) Abstract Human type 1 diabetes mellitus (T1DM) arises through autoimmune destruction of pancreatic β cells and is modeled in many respects by the lymphopenic and spontaneously diabetic BioBreeding (BB) DRlyp/lyp rat. Previously, pre-onset expression profiling of whole DRlyp/lyp pancreatic lymph nodes (PLN) revealed innate immune activity, specifically that of mast cells and eosinophils. Furthermore, we observed that pancreatic islets of DRlyp/lyp rats as well as those of diabetes-inducible BB DR+/+ rats potentially recruit innate cells through eotaxin expression. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS2742
Platform:: GPL1355
4 Samples

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Series

Accession:: GSE4990

ID:: 200004990

Select item 27422.

Type 1 diabetes mellitus model: mast cells

Analysis of mast cells isolated from the pancreatic lymph nodes of 60 day old prediabetic BioBiobreeding (BB) DR lyp/lyp animals. The BB DR lyp/lyp strain is a model for type 1 diabetes mellitus (T1DM). Results provide insight into the role of mast cells in the pathogenesis of T1DM.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 strain sets

Platform:: GPL1355
Series:: GSE4990
4 Samples

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DataSet

Accession:: GDS2742

ID:: 2742

Select item 1000013553.

[Rat230_2] Affymetrix Rat Genome 230 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 27, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The GeneChip Rat Genome 230 2.0 Array is a powerful tool for toxicology, neurobiology, and other applications using rat as a model organism. more...