GEO DataSets

(Submitter supplied) JC virus (JCV) is a ubiquitous human polyomavirus that causes the demyelinating disease Progressive Multifocal Leukoencephalopathy (PML). JCV replicates in limited cell types in culture, predominantly in human glial cells. Thus, productive JCV infection is an indicator of the host cell transcription environment. Following introduction of a replication defective SV40 mutant that expressed large T protein into a heterogeneous culture of human fetal brain cells, multiple phenotypes became immortalized (SVG cells). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4852

Platform:

GPL6244

13 Samples

Download data: CEL

Analysis of fetal glial cell line SVG-derived clones 10B1 and 5F4 following infection with JCV. Clone SVG-5F4 shows low levels of viral growth, whereas clone SVG-10B1 is highly permissive to JCV infection. Results provide insight into cell type differences in JCV host range and pathogenesis.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 cell line, 2 infection, 3 other sets

Platform:

GPL6244

Series:

GSE45639

13 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 18, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: See manufacturer's web site

Organism:

Homo sapiens

136 DataSets

1879 Series

27 Related Platforms

38399 Samples

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