GEO DataSets

(Submitter supplied) Focal amplifications of 3p13-3p14 occur in about 10% of melanoma and are associated with poor prognosis. The melanoma-specific oncogene MITF resides at the epicenter of this amplicon1. However, whether other loci present in this amplicon also contribute to melanomagenesis is unknown. Here we show that the recently annotated long non-coding RNA gene LINC01212 is consistently co-gained with MITF. In addition to being amplified, LINC01212 is a target of the lineage-specific transcription factor SOX10 and, consequently, it is expressed in more than 90% of human melanomas, but not in normal adult tissues. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17077

9 Samples

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(Submitter supplied) SurePrint G3 Human GE v2 8x60K Microarray Design ID: 039494 Design Format: 8 x 60 K Control Grid: IS-62976-8-V2_60kby8_GX_EQC_201000210 Build Version: hg19:GRCh37:Feb2009 Arrays of this design have barcodes that begin with 16039494 or 2539494. Orientation: Features are numbered numbered Left-to-Right, Top-to-Bottom as scanned by an Agilent scanner (barcode on the left, DNA on the back surface, scanned through the glass), matching the FeatureNum output from Agilent's Feature Extraction software. more...

Organism:

Homo sapiens

577 Series

1 Related Platform

9541 Samples

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