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Items: 7

1.

Developmental LTbR synergistically activates TLR4 mediated inflammatory RelA/NF-kB response

(Submitter supplied) Developmental signals are known to modulate inflammation. How ever, the mechanistic insight that links developmental and inflammatory signaling remains elusive. In the current study, we identifya critical role of NF-kB system in mediating stimulus specific crosstalk that allows developmental LTbR signals to sustain inflammatory TLR4 induced RelA/NF-kB response and gene expression. LTbR activated non-canonical signaling targets canonical TLR4 induced, nfkb2 encoded p100 not only to deplete inhibitory IkBd/(p100)2, but also to supplement RelA:p52/NF-kB dimers. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5655
Platform:
GPL6885
4 Samples
Download data: TXT
Series
Accession:
GSE62301
ID:
200062301
2.
Full record GDS5655

Lymphotoxin-β receptor agonist antibody effect on lipopolysaccharide-stimulated embryonic fibroblasts

Analysis of MEFs treated for 24hrs with ligands lipopolysaccharide (LPS), lymphotoxin-β receptor agonist antibody (LTβR), and LPS+ LTβR. Results provide insight into molecular mechanisms underlying a potentially synergistic effect of LTβR signaling on LPS-TLR4 signaling.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 4 protocol sets
Platform:
GPL6885
Series:
GSE62301
4 Samples
Download data
3.

Illumina MouseRef-8 v2.0 expression beadchip

(Submitter supplied) The MouseRef-8 v2.0 Expression BeadChip offer the most up-to-date content for whole-genome expression profiling in the mouse. Featuring content derived from the National Center for Biotechnology Information Reference Sequence (NCBI RefSeq) database (Build 36, Release 22). Please use the GEO Data Submission Report Plug-in v1.0 for Gene Expression which may be downloaded from https://icom.illumina.com/icom/software.ilmn?id=234 to format the normalized and raw data. more...
Organism:
Mus musculus
33 DataSets
903 Series
16894 Samples
Download data: BGX
Platform
Accession:
GPL6885
ID:
100006885
4.

WT LPS+LTbR 24 hrs

Organism:
Mus musculus
Source name:
Mouse embryonic fibroblasts
Platform:
GPL6885
Series:
GSE62301
Dataset:
GDS5655
Download data
Sample
Accession:
GSM1525027
ID:
301525027
5.

WT LTbR 24 hrs

Organism:
Mus musculus
Source name:
Mouse embryonic fibroblasts
Platform:
GPL6885
Series:
GSE62301
Dataset:
GDS5655
Download data
Sample
Accession:
GSM1525026
ID:
301525026
6.

WT LPS 24 hrs

Organism:
Mus musculus
Source name:
Mouse embryonic fibroblasts
Platform:
GPL6885
Series:
GSE62301
Dataset:
GDS5655
Download data
Sample
Accession:
GSM1525025
ID:
301525025
7.

WT 0 hr

Organism:
Mus musculus
Source name:
Mouse embryonic fibroblasts
Platform:
GPL6885
Series:
GSE62301
Dataset:
GDS5655
Download data
Sample
Accession:
GSM1525024
ID:
301525024
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Supplemental Content

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