GSE43702[Accession] - GEO DataSets - NCBI

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Select item 2000437021.

Gene expression profiles of MCF7 breast cancer cells following estrogen and anti-estrogen treatment.

(Submitter supplied) We have previously demonstrated that endoxifen is the most important tamoxifen metabolite responsible for eliciting the anti-estrogenic effects of this drug in breast cancer cells expressing estrogen receptor-alpha. The goals of this study were to compare the gene expression profiles elicited by endoxifen to that of other anti-estrogens in MCF7 cells. We also examined the gene expression profiles elicited by various endoxifen concentrations in the presence of tamoxifen and its other primary metabolites in order to better understand the molecular contributions of endoxifen to the effects of tamoxifen.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6947
38 Samples

Download data: TXT

Series

Accession:: GSE43702

ID:: 200043702

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000069472.

Illumina HumanHT-12 V3.0 expression beadchip

(Submitter supplied) The HumanHT-12 V3.0 Expression BeadChip features up-to-date content derived from the National Center for Biotechnology Information Reference Sequence (NCBI RefSeq) database (Build 36.2, Release 22). Please use the GEO Data Submission Report Plug-in v1.0 for Gene Expression which may be downloaded from https://icom.illumina.com/icom/software.ilmn?id=234 to format the normalized and raw data. These should be submitted as part of a GEOarchive. more...

Organism:: Homo sapiens

13 DataSets
542 Series
1 Related Platform
26115 Samples

Download data: BGX

Platform

Accession:: GPL6947

ID:: 100006947

Select item 3010686643.

MCF7, 10 nM estradiol + 300 nM tamoxifen + 7 nM 4HT + 700 nM N-desmethyl-tamoxifen + 20 nM endoxifen, 24 h, rep 3

Organism:: Homo sapiens

Source name:: Parental MCF7 cells

Platform:: GPL6947
Series:: GSE43702

Sample

Accession:: GSM1068664

ID:: 301068664

Select item 3010686634.

MCF7, 10 nM estradiol + 300 nM tamoxifen + 7 nM 4HT + 700 nM N-desmethyl-tamoxifen + 20 nM endoxifen, 24 h, rep 2

Organism:: Homo sapiens

Source name:: Parental MCF7 cells

Platform:: GPL6947
Series:: GSE43702

Sample

Accession:: GSM1068663

ID:: 301068663

Select item 3010686625.

MCF7, 10 nM estradiol + 300 nM tamoxifen + 7 nM 4HT + 700 nM N-desmethyl-tamoxifen + 20 nM endoxifen, 24 h, rep 1

Organism:: Homo sapiens

Source name:: Parental MCF7 cells

Platform:: GPL6947
Series:: GSE43702

Sample

Accession:: GSM1068662

ID:: 301068662

Select item 3010686616.

MCF7, 10 nM estradiol + 300 nM tamoxifen + 7 nM 4HT + 700 nM N-desmethyl-tamoxifen + 100 nM endoxifen, 24 h, rep 3

Organism:: Homo sapiens

Source name:: Parental MCF7 cells

Platform:: GPL6947
Series:: GSE43702

Sample

Accession:: GSM1068661

ID:: 301068661

Select item 3010686607.

MCF7, 10 nM estradiol + 300 nM tamoxifen + 7 nM 4HT + 700 nM N-desmethyl-tamoxifen + 100 nM endoxifen, 24 h, rep 2

Organism:: Homo sapiens

Source name:: Parental MCF7 cells

Platform:: GPL6947
Series:: GSE43702

Sample

Accession:: GSM1068660

ID:: 301068660

Select item 3010686598.

MCF7, 10 nM estradiol + 300 nM tamoxifen + 7 nM 4HT + 700 nM N-desmethyl-tamoxifen + 100 nM endoxifen, 24 h, rep 1

Organism:: Homo sapiens

Source name:: Parental MCF7 cells

Platform:: GPL6947
Series:: GSE43702

Sample

Accession:: GSM1068659

ID:: 301068659

Select item 3010686589.

MCF7, 10 nM estradiol + 300 nM tamoxifen + 7 nM 4HT + 700 nM N-desmethyl-tamoxifen + 1000 nM endoxifen, 24 h, rep 3

Organism:: Homo sapiens

Source name:: Parental MCF7 cells

Platform:: GPL6947
Series:: GSE43702

Sample

Accession:: GSM1068658

ID:: 301068658

Select item 30106865710.

MCF7, 10 nM estradiol + 300 nM tamoxifen + 7 nM 4HT + 700 nM N-desmethyl-tamoxifen + 1000 nM endoxifen, 24 h, rep 2

Organism:: Homo sapiens

Source name:: Parental MCF7 cells

Platform:: GPL6947
Series:: GSE43702

Sample

Accession:: GSM1068657

ID:: 301068657

Select item 30106865611.

MCF7, 10 nM estradiol + 300 nM tamoxifen + 7 nM 4HT + 700 nM N-desmethyl-tamoxifen + 1000 nM endoxifen, 24 h, rep 1

Organism:: Homo sapiens

Source name:: Parental MCF7 cells

Platform:: GPL6947
Series:: GSE43702

Sample

Accession:: GSM1068656

ID:: 301068656

Select item 30106865512.

MCF7, 10 nM estradiol + 300 nM tamoxifen + 7 nM 4HT + 700 nM N-desmethyl-tamoxifen, 24 h, rep 3

Organism:: Homo sapiens

Source name:: Parental MCF7 cells

Platform:: GPL6947
Series:: GSE43702

Sample

Accession:: GSM1068655

ID:: 301068655

Select item 30106865413.

MCF7, 10 nM estradiol + 300 nM tamoxifen + 7 nM 4HT + 700 nM N-desmethyl-tamoxifen, 24 h, rep 2

Organism:: Homo sapiens

Source name:: Parental MCF7 cells

Platform:: GPL6947
Series:: GSE43702

Sample

Accession:: GSM1068654

ID:: 301068654

Select item 30106865314.

MCF7, 10 nM estradiol + 300 nM tamoxifen + 7 nM 4HT + 700 nM N-desmethyl-tamoxifen, 24 h, rep 1

Organism:: Homo sapiens

Source name:: Parental MCF7 cells

Platform:: GPL6947
Series:: GSE43702

Sample

Accession:: GSM1068653

ID:: 301068653

Select item 30106865215.

MCF7, 10 nM estradiol + 100 nM ICI, 24 h, rep 3

Organism:: Homo sapiens

Source name:: Parental MCF7 cells

Platform:: GPL6947
Series:: GSE43702

Sample

Accession:: GSM1068652

ID:: 301068652

Select item 30106865116.

MCF7, 10 nM estradiol + 100 nM ICI, 24 h, rep 2

Organism:: Homo sapiens

Source name:: Parental MCF7 cells

Platform:: GPL6947
Series:: GSE43702

Sample

Accession:: GSM1068651

ID:: 301068651

Select item 30106865017.

MCF7, 10 nM estradiol + 100 nM ICI, 24 h, rep 1

Organism:: Homo sapiens

Source name:: Parental MCF7 cells

Platform:: GPL6947
Series:: GSE43702

Sample

Accession:: GSM1068650

ID:: 301068650

Select item 30106864918.

MCF7, 10 nM estradiol + 100 nM endoxifen, 24 h, rep 3

Organism:: Homo sapiens

Source name:: Parental MCF7 cells

Platform:: GPL6947
Series:: GSE43702

Sample

Accession:: GSM1068649

ID:: 301068649

Select item 30106864819.

MCF7, 10 nM estradiol + 100 nM endoxifen, 24 h, rep 2

Organism:: Homo sapiens

Source name:: Parental MCF7 cells

Platform:: GPL6947
Series:: GSE43702

Sample

Accession:: GSM1068648

ID:: 301068648

Select item 30106864720.

MCF7, 10 nM estradiol + 100 nM endoxifen, 24 h, rep 1

Organism:: Homo sapiens

Source name:: Parental MCF7 cells

Platform:: GPL6947
Series:: GSE43702

Sample

Accession:: GSM1068647

ID:: 301068647

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