GSE4140[Accession] - GEO DataSets

Select item 2000041401.

NF639 cells original population vs EGCG-resistant population

(Submitter supplied) Overexpression of the epidermal growth factor receptor family member Her-2/neu in breast cancer leads to autophosphorylation of the receptor, and induction of multiple downstream signaling pathways including Akt kinase to NF-kappaB cascade that is associated with poor prognosis. Previously, we demonstrated green tea polyhenol epigallocatechin 3-gallate (EGCG) inhibits growth of NF639 Her-2/neu-driven breast cancer cells via reducing receptor autophosphorylation, and downstream Akt and NF-kappaB activities (Pianetti et al., 2002). more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS2138
Platform:: GPL339
4 Samples

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Series

Accession:: GSE4140

ID:: 200004140

Select item 21382.

Breast cancer cells resistant to green tea polyphenol epigallocatechin 3-gallate growth inhibition

Analysis of NF639 breast cancer cells resistant to growth inhibition by green tea polyphenol epigallocatechin 3-gallate (EGCG) after initial EGCG sensitivity. EGCG inhibits growth of NF639 cells by inhibiting Her-2/Neu signaling. Results provide insight into mechanisms underlying EGCG resistance.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 isolate sets

Platform:: GPL339
Series:: GSE4140
4 Samples

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DataSet

Accession:: GDS2138

ID:: 2138

Select item 1000003393.

[MOE430A] Affymetrix Mouse Expression 430A Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html The GeneChip Mouse Genome 430A 2.0 Array is accessioned in GEO as GPL8321. June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 24, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The GeneChip Mouse Genome 430A Array is a single array representing approximately 14,000 well-characterized mouse genes that can be used to explore biology and disease processes. more...