GEO DataSets

(Submitter supplied) We have conducted a screen for factors that downregulate expression of the genes encoding the V(D)J recombinase (RAG1 and RAG2) during B cell development. We have identified the transcription factor Gfi1B as being one of the proteins capable of decreasing RAG transcription when overexpressed in Ableson transormed ProB cell lines. We have yet to determine whether the overexpression of Gfi1B downregulates the RAGs directly, or whether it initiates a signalling programme that results in RAG downregulation. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4302

Platform:

GPL6246

6 Samples

Download data: CEL, TXT

Analysis of Abelson murine leukemia virus (AMuLV) pro-B cell line expressing Gfi1b-estrogen receptor fusion protein. Targeted disruption of transcription factor Gfi1b severly impacts B cell development in vivo. Results provide insight into the role of Gfi1b in normal B cell development.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL6246

Series:

GSE33709

6 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: See manufacturer's web site

Organism:

Mus musculus

143 DataSets

2504 Series

28 Related Platforms

30419 Samples

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