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Items: 1 to 20 of 59

1.

The novel antisense Bcl-2 inhibitor SPC2996 causes rapid leukemic cell clearance and immune activation in chronic lymphocytic leukemia

(Submitter supplied) SPC2996 is a novel locked nucleic acid (LNA) phosphorothioate antisense molecule targeting the mRNA of the Bcl-2 oncoprotein. We investigated the mechanism of action of SPC2996 and the basis for its clinically observed immunostimulatory effects in chronic lymphocytic leukemia (CLL). Patients with relapsed CLL were treated with a maximum of six doses of SPC2996 (0.2-6mg/ kg) in a multicenter phase I trial. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4284
Platform:
GPL570
56 Samples
Download data: CEL, CHP
Series
Accession:
GSE27858
ID:
200027858
2.
Full record GDS4284

Chronic lymphocytic leukemia response to antisense Bcl-2 inhibitor SPC2996: peripheral blood

Temporal analysis of peripheral blood from 18 relapsed CLL patients treated with a maximum of 6 doses (0.2-6mg/kg) of SPC2996, an antisense molecule targeting the mRNA of Bcl-2 oncoprotein. Results provide insight into the molecular basis of the immunostimulatory effects of SPC2996 in CLL.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 6 dose, 18 individual, 4 time sets
Platform:
GPL570
Series:
GSE27858
56 Samples
Download data: CEL, CHP
DataSet
Accession:
GDS4284
ID:
4284
3.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...
Organism:
Homo sapiens
602 DataSets
5670 Series
61 Related Platforms
175576 Samples
Download data
Platform
Accession:
GPL570
ID:
100000570
4.

Patient 452 treated 4 weeks

Organism:
Homo sapiens
Source name:
Patient 452 treated 4 weeks
Platform:
GPL570
Series:
GSE27858
Dataset:
GDS4284
Download data: CEL, CHP
Sample
Accession:
GSM687731
ID:
300687731
5.

Patient 452 treated 4h

Organism:
Homo sapiens
Source name:
Patient 452 treated 4h
Platform:
GPL570
Series:
GSE27858
Dataset:
GDS4284
Download data: CEL, CHP
Sample
Accession:
GSM687730
ID:
300687730
6.

Patient 452 treated 24h

Organism:
Homo sapiens
Source name:
Patient 452 treated 24h
Platform:
GPL570
Series:
GSE27858
Dataset:
GDS4284
Download data: CEL, CHP
Sample
Accession:
GSM687729
ID:
300687729
7.

Patient 452 control

Organism:
Homo sapiens
Source name:
Patient 452 control
Platform:
GPL570
Series:
GSE27858
Dataset:
GDS4284
Download data: CEL, CHP
Sample
Accession:
GSM687728
ID:
300687728
8.

Patient 451 treated 4 weeks

Organism:
Homo sapiens
Source name:
Patient 451 treated 4 weeks
Platform:
GPL570
Series:
GSE27858
Dataset:
GDS4284
Download data: CEL, CHP
Sample
Accession:
GSM687727
ID:
300687727
9.

Patient 451 treated 4h

Organism:
Homo sapiens
Source name:
Patient 451 treated 4h
Platform:
GPL570
Series:
GSE27858
Dataset:
GDS4284
Download data: CEL, CHP
Sample
Accession:
GSM687726
ID:
300687726
10.

Patient 451 treated 24h

Organism:
Homo sapiens
Source name:
Patient 451 treated 24h
Platform:
GPL570
Series:
GSE27858
Dataset:
GDS4284
Download data: CEL, CHP
Sample
Accession:
GSM687725
ID:
300687725
11.

Patient 451 control

Organism:
Homo sapiens
Source name:
Patient 451 control
Platform:
GPL570
Series:
GSE27858
Dataset:
GDS4284
Download data: CEL, CHP
Sample
Accession:
GSM687724
ID:
300687724
12.

Patient 450 treated 4 weeks

Organism:
Homo sapiens
Source name:
Patient 450 treated 4 weeks
Platform:
GPL570
Series:
GSE27858
Dataset:
GDS4284
Download data: CEL, CHP
Sample
Accession:
GSM687723
ID:
300687723
13.

Patient 450 treated 4h

Organism:
Homo sapiens
Source name:
Patient 450 treated 4h
Platform:
GPL570
Series:
GSE27858
Dataset:
GDS4284
Download data: CEL, CHP
Sample
Accession:
GSM687722
ID:
300687722
14.

Patient 450 treated 24h

Organism:
Homo sapiens
Source name:
Patient 450 treated 24h
Platform:
GPL570
Series:
GSE27858
Dataset:
GDS4284
Download data: CEL, CHP
Sample
Accession:
GSM687721
ID:
300687721
15.

Patient 450 control

Organism:
Homo sapiens
Source name:
Patient 450 control
Platform:
GPL570
Series:
GSE27858
Dataset:
GDS4284
Download data: CEL, CHP
Sample
Accession:
GSM687719
ID:
300687719
16.

Patient 449 treated 4 weeks

Organism:
Homo sapiens
Source name:
Patient 449 treated 4 weeks
Platform:
GPL570
Series:
GSE27858
Dataset:
GDS4284
Download data: CEL, CHP
Sample
Accession:
GSM687718
ID:
300687718
17.

Patient 449 treated 4h

Organism:
Homo sapiens
Source name:
Patient 449 treated 4h
Platform:
GPL570
Series:
GSE27858
Dataset:
GDS4284
Download data: CEL, CHP
Sample
Accession:
GSM687716
ID:
300687716
18.

Patient 449 treated 24h

Organism:
Homo sapiens
Source name:
Patient 449 treated 24h
Platform:
GPL570
Series:
GSE27858
Dataset:
GDS4284
Download data: CEL, CHP
Sample
Accession:
GSM687714
ID:
300687714
19.

Patient 449 control

Organism:
Homo sapiens
Source name:
Patient 449 control
Platform:
GPL570
Series:
GSE27858
Dataset:
GDS4284
Download data: CEL, CHP
Sample
Accession:
GSM687712
ID:
300687712
20.

Patient 448 treated 4h

Organism:
Homo sapiens
Source name:
Patient 448 treated 4h
Platform:
GPL570
Series:
GSE27858
Dataset:
GDS4284
Download data: CEL, CHP
Sample
Accession:
GSM687710
ID:
300687710
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Supplemental Content

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