GEO DataSets

(Submitter supplied) The β-amyloid precursor protein APP and the related APLPs, undergo complex proteolytic processing giving rise to several fragments. Whereas it is well established that Aβ accumulation is a central trigger for Alzheimer disease (AD), the physiological role of APP family members and their diverse proteolytic products is still largely unknown. The secreted APPsα ectodomain has been shown to be involved in neuroprotection and synaptic plasticity. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4414

Platform:

GPL1261

15 Samples

Download data: CEL

Analysis of prefrontal cortex of adult wild-type, APP knockout, APLP2 knockout, and APPsα knockin (solely expressing the secreted APPsα ectodomain) males. β-amyloid accumulation is a key trigger for Alzheimer's disease. Results provide insight into physiological functions of APP family members.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 4 genotype/variation, 2 strain sets

Platform:

GPL1261

Series:

GSE25926

15 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...

Organism:

Mus musculus

601 DataSets

4547 Series

40 Related Platforms

58950 Samples

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