GSE247350[Accession] - GEO DataSets - NCBI

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Items: 10

Select item 2002473501.

COMMD10-deficiency in adipose tissue macrophages attenuates obesity and insulin resistance by boosting mitochondrial and antioxidant functions

(Submitter supplied) During obesity, adipose tissue macrophages (ATM) colonize the white adipose tissue (WAT), where they adapt inflammatory and metabolically activated phenotypes. Here, we demonstrate that COMMD10 is a key regulator of macrophage oxidative capacity in response to chronic caloric excess. Mice with COMMD10-deficiency targeted to macrophages were fed with high-fat-diet (HFD) for 12 weeks. They gained less weight despite similar food intake, and showed improved systemic metabolic indices, sustained adipose tissue insulin sensitivity, increased lipolysis and reduced adipocyte hypertrophy and liver steatosis. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
8 Samples

Download data: TSV

Series

Accession:: GSE247350

ID:: 200247350

Select item 1000190572.

Illumina NextSeq 500 (Mus musculus)

Organism:: Mus musculus

10340 Series
296909 Samples

Platform

Accession:: GPL19057

ID:: 100019057

Select item 3078876113.

Organism:: Mus musculus

Source name:: epiWAT

Platform:: GPL19057
Series:: GSE247350

Download data: TSV

Sample

Accession:: GSM7887611

ID:: 307887611

SRA Run Selector

Select item 3078876104.

Organism:: Mus musculus

Source name:: epiWAT

Platform:: GPL19057
Series:: GSE247350

Download data: TSV

Sample

Accession:: GSM7887610

ID:: 307887610

SRA Run Selector

Select item 3078876095.

Organism:: Mus musculus

Source name:: epiWAT

Platform:: GPL19057
Series:: GSE247350

Download data: TSV

Sample

Accession:: GSM7887609

ID:: 307887609

SRA Run Selector

Select item 3078876086.

Organism:: Mus musculus

Source name:: epiWAT

Platform:: GPL19057
Series:: GSE247350

Download data: TSV

Sample

Accession:: GSM7887608

ID:: 307887608

SRA Run Selector

Select item 3078876077.

Organism:: Mus musculus

Source name:: epiWAT

Platform:: GPL19057
Series:: GSE247350

Download data: TSV

Sample

Accession:: GSM7887607

ID:: 307887607

SRA Run Selector

Select item 3078876068.

Organism:: Mus musculus

Source name:: epiWAT

Platform:: GPL19057
Series:: GSE247350

Download data: TSV

Sample

Accession:: GSM7887606

ID:: 307887606

SRA Run Selector

Select item 3078876059.

Organism:: Mus musculus

Source name:: epiWAT

Platform:: GPL19057
Series:: GSE247350

Download data: TSV

Sample

Accession:: GSM7887605

ID:: 307887605

SRA Run Selector

Select item 30788760410.

Organism:: Mus musculus

Source name:: epiWAT

Platform:: GPL19057
Series:: GSE247350

Download data: TSV

Sample

Accession:: GSM7887604

ID:: 307887604

SRA Run Selector

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GSE247350[Accession] (10)
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