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Items: 9

1.

Genome-wide CRISPR screen of MOLM13 cells after Idasanutlin treatment

(Submitter supplied) Targeting MDM2 is an attractive therapeutic approach for TP53 wild-type (WT) tumors, including the majority of de novo acute myeloid leukemia (AML) cases. However, patients with WT TP53 have shown variable responses to MDM2 inhibitors in clinical trials, highlighting the need to identify additional biomarkers to maximize the chances of clinical success. We performed CRISPR-Cas9 knockout screens to identify genes that confer resistance to an MDM2 inhibitor idasanutlin. more...
Organism:
synthetic construct; Homo sapiens
Type:
Other
Platforms:
GPL19604 GPL16791
6 Samples
Download data: TXT
Series
Accession:
GSE240977
ID:
200240977

2.

Illumina HiSeq 2500 (synthetic construct)

Organism:
synthetic construct
61 Series
5354 Samples
Download data
Platform
Accession:
GPL19604
ID:
100019604

3.

Illumina HiSeq 2500 (Homo sapiens)

Organism:
Homo sapiens
12219 Series
349638 Samples
Download data
Platform
Accession:
GPL16791
ID:
100016791

4.

Yusa plasmid

Organism:
synthetic construct
Source name:
na
Platform:
GPL19604
Series:
GSE240977 GSE241674
Download data
Sample
Accession:
GSM7713307
ID:
307713307

SRA Run Selector

5.

MOLM13 DMSO D14 Replicate 2

Organism:
Homo sapiens
Source name:
MOLM13
Platform:
GPL16791
Series:
GSE240977 GSE241674
Download data
Sample
Accession:
GSM7713306
ID:
307713306

SRA Run Selector

6.

MOLM13 DMSO D14 Replicate 1

Organism:
Homo sapiens
Source name:
MOLM13
Platform:
GPL16791
Series:
GSE240977 GSE241674
Download data
Sample
Accession:
GSM7713305
ID:
307713305

SRA Run Selector

7.

MOLM13 Idasanutlin 50nM D14 Replicate 1

Organism:
Homo sapiens
Source name:
MOLM13
Platform:
GPL16791
Series:
GSE240977 GSE241674
Download data
Sample
Accession:
GSM7713304
ID:
307713304

SRA Run Selector

8.

MOLM13 Idasanutlin 200nM D14 Replicate 2

Organism:
Homo sapiens
Source name:
MOLM13
Platform:
GPL16791
Series:
GSE240977 GSE241674
Download data
Sample
Accession:
GSM7713303
ID:
307713303

SRA Run Selector

9.

MOLM13 Idasanutlin 200nM D14 Replicate 1

Organism:
Homo sapiens
Source name:
MOLM13
Platform:
GPL16791
Series:
GSE240977 GSE241674
Download data
Sample
Accession:
GSM7713302
ID:
307713302

SRA Run Selector

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