GEO DataSets

(Submitter supplied) Treatment of acute promyelocytic leukemia (APL) with all-trans-retinoic acid (ATRA) results in terminal differentiation of leukemic cells toward neutrophil granulocytes. Administration of ATRA leads to massive changes in gene expression, including down-regulation of cell proliferation-related genes and induction of genes involved in immune function. One of the most induced genes in APL NB4 cells is transglutaminase 2 (TG2). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4180

Platform:

GPL6244

18 Samples

Download data: CEL, CHP

Analysis of stable TG2-knockdown NB4 APL cells induced to differentiate in the presence of all-trans-retinoic acid (ATRA) for up to 72 hrs. Silencing of TG2 delays the differentiation process of NB4 cells. Results provide insight into the role of TG2 in the ATRA-induced differentiation of NB4 cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 2 genotype/variation, 3 time sets

Platform:

GPL6244

Series:

GSE23702

18 Samples

Download data: CEL, CHP

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 18, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: See manufacturer's web site

Organism:

Homo sapiens

136 DataSets

1879 Series

27 Related Platforms

38399 Samples

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