GSE19534[Accession] - GEO DataSets - NCBI

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Select item 2000195341.

Alpha-synuclein deficiency affects brain Foxp1 expression and ultrasonic vocalization

(Submitter supplied) Alpha-synuclein is an abundant protein implicated in synaptic function and plasticity, but the molecular mechanism of its action is not understood. Missense mutations and gene duplication/triplication events result in Parkinson's disease, a neurodegenerative disorder of old age with impaired movement and emotion control. Here, we systematically investigated the striatal as well as the cerebellar transcriptome profile of alpha-synuclein-deficient mice via a genome-wide microarray survey in order to gain hypothesis-free molecular insights into the physiological function of alpha-synuclein. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4153
Platform:: GPL1261
26 Samples

Download data: CEL

Series

Accession:: GSE19534

ID:: 200019534

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 41532.

Full record GDS4153

Alpha-synuclein deficiency effect on striatum and cerebellum: time course

Analysis of striatum and cerebellum from alpha-synuclein (SNCA) knockouts at 6 or 21 months of age. SNCA mutations result in impaired movement and depression/anxiety, manifesting in humans as Parkinson's disease (PD). Results provide molecular insights into physiological role of alpha-synuclein.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 genotype/variation, 2 time, 2 tissue sets

Platform:: GPL1261
Series:: GSE19534
26 Samples

Download data: CEL

DataSet

Accession:: GDS4153

ID:: 4153

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 1000012613.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...

Organism:: Mus musculus

601 DataSets
4547 Series
40 Related Platforms
58950 Samples

Platform

Accession:: GPL1261

ID:: 100001261

Select item 3004870714.

striatum SNCA knockout 21 month replicate 3

Organism:: Mus musculus

Source name:: striatum_21 month

Platform:: GPL1261
Series:: GSE19534
Dataset:: GDS4153

Download data: CEL

Sample

Accession:: GSM487071

ID:: 300487071

Select item 3004870705.

striatum SNCA knockout 21 month replicate 2

Organism:: Mus musculus

Source name:: striatum_21 month

Platform:: GPL1261
Series:: GSE19534
Dataset:: GDS4153

Download data: CEL

Sample

Accession:: GSM487070

ID:: 300487070

Select item 3004870696.

striatum SNCA knockout 21 month replicate 1

Organism:: Mus musculus

Source name:: striatum_21 month

Platform:: GPL1261
Series:: GSE19534
Dataset:: GDS4153

Download data: CEL

Sample

Accession:: GSM487069

ID:: 300487069

Select item 3004870687.

striatum wild type 21 month replicate 3

Organism:: Mus musculus

Source name:: striatum_21 month

Platform:: GPL1261
Series:: GSE19534
Dataset:: GDS4153

Download data: CEL

Sample

Accession:: GSM487068

ID:: 300487068

Select item 3004870678.

striatum wild type 21 month replicate 2

Organism:: Mus musculus

Source name:: striatum_21 month

Platform:: GPL1261
Series:: GSE19534
Dataset:: GDS4153

Download data: CEL

Sample

Accession:: GSM487067

ID:: 300487067

Select item 3004870669.

striatum wild type 21 month replicate 1

Organism:: Mus musculus

Source name:: striatum_21 month

Platform:: GPL1261
Series:: GSE19534
Dataset:: GDS4153

Download data: CEL

Sample

Accession:: GSM487066

ID:: 300487066

Select item 30048706510.

cerebellum SNCA knockout 21 month replicate 4

Organism:: Mus musculus

Source name:: cerebellum_21 month

Platform:: GPL1261
Series:: GSE19534
Dataset:: GDS4153

Download data: CEL

Sample

Accession:: GSM487065

ID:: 300487065

Select item 30048706411.

cerebellum SNCA knockout 21 month replicate 3

Organism:: Mus musculus

Source name:: cerebellum_21 month

Platform:: GPL1261
Series:: GSE19534
Dataset:: GDS4153

Download data: CEL

Sample

Accession:: GSM487064

ID:: 300487064

Select item 30048706312.

cerebellum SNCA knockout 21 month replicate 2

Organism:: Mus musculus

Source name:: cerebellum_21 month

Platform:: GPL1261
Series:: GSE19534
Dataset:: GDS4153

Download data: CEL

Sample

Accession:: GSM487063

ID:: 300487063

Select item 30048706213.

cerebellum SNCA knockout 21 month replicate 1

Organism:: Mus musculus

Source name:: cerebellum_21 month

Platform:: GPL1261
Series:: GSE19534
Dataset:: GDS4153

Download data: CEL

Sample

Accession:: GSM487062

ID:: 300487062

Select item 30048706114.

cerebellum wild type 21 month replicate 4

Organism:: Mus musculus

Source name:: cerebellum_21 month

Platform:: GPL1261
Series:: GSE19534
Dataset:: GDS4153

Download data: CEL

Sample

Accession:: GSM487061

ID:: 300487061

Select item 30048706015.

cerebellum wild type 21 month replicate 3

Organism:: Mus musculus

Source name:: cerebellum_21 month

Platform:: GPL1261
Series:: GSE19534
Dataset:: GDS4153

Download data: CEL

Sample

Accession:: GSM487060

ID:: 300487060

Select item 30048705916.

cerebellum wild type 21 month replicate 2

Organism:: Mus musculus

Source name:: cerebellum_21 month

Platform:: GPL1261
Series:: GSE19534
Dataset:: GDS4153

Download data: CEL

Sample

Accession:: GSM487059

ID:: 300487059

Select item 30048705817.

cerebellum wild type 21 month replicate 1

Organism:: Mus musculus

Source name:: cerebellum_21 month

Platform:: GPL1261
Series:: GSE19534
Dataset:: GDS4153

Download data: CEL

Sample

Accession:: GSM487058

ID:: 300487058

Select item 30048705718.

striatum SNCA knockout 6 month replicate 3

Organism:: Mus musculus

Source name:: striatum_6 month

Platform:: GPL1261
Series:: GSE19534
Dataset:: GDS4153

Download data: CEL

Sample

Accession:: GSM487057

ID:: 300487057

Select item 30048705619.

striatum SNCA knockout 6 month replicate 2

Organism:: Mus musculus

Source name:: striatum_6 month

Platform:: GPL1261
Series:: GSE19534
Dataset:: GDS4153

Download data: CEL

Sample

Accession:: GSM487056

ID:: 300487056

Select item 30048705520.

striatum SNCA knockout 6 month replicate 1

Organism:: Mus musculus

Source name:: striatum_6 month

Platform:: GPL1261
Series:: GSE19534
Dataset:: GDS4153

Download data: CEL

Sample

Accession:: GSM487055

ID:: 300487055

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