GSE173374[Accession] - GEO DataSets - NCBI

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Select item 2001733741.

THOC5 complexes with DDX5, DDX17 and CDK12 to regulate R loop structures and transcription elongation rate

(Submitter supplied) THOC5, a member of the THO complex, is essential for the 3´processing of some inducible genes, the export of a subset of genes and stem cell self-renewal. Utilising nanopore mRNA-sequencing we show that when THOC5 is depleted 50-60% of mRNAs undergo altered 3´end cleavage. Further, THOC5 depletion leads to increased RNA Polymerase II (Pol II) presence at the start site, on the gene body and close to the 3’end. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL16791 GPL24106
29 Samples

Download data: BIGWIG, CSV, XLSX

Series

Accession:: GSE173374

ID:: 200173374

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 1000241062.

MinION (Homo sapiens)

Organism:: Homo sapiens

158 Series
1955 Samples

Platform

Accession:: GPL24106

ID:: 100024106

Select item 1000167913.

Illumina HiSeq 2500 (Homo sapiens)

Organism:: Homo sapiens

12223 Series
349703 Samples

Platform

Accession:: GPL16791

ID:: 100016791

Select item 3062572784.

HEK293 Slow Pol II Nanopore

Organism:: Homo sapiens

Source name:: kidney

Platform:: GPL24106
Series:: GSE173374

Sample

Accession:: GSM6257278

ID:: 306257278

SRA Run Selector

Select item 3062572775.

HEK293 Fast Pol II Nanopore

Organism:: Homo sapiens

Source name:: kidney

Platform:: GPL24106
Series:: GSE173374

Sample

Accession:: GSM6257277

ID:: 306257277

SRA Run Selector

Select item 3062572766.

HEK293 siCDK12 Nanopore

Organism:: Homo sapiens

Source name:: kidney

Platform:: GPL24106
Series:: GSE173374

Sample

Accession:: GSM6257276

ID:: 306257276

SRA Run Selector

Select item 3062572757.

HEK293 siTHOC6 Nanopore

Organism:: Homo sapiens

Source name:: kidney

Platform:: GPL24106
Series:: GSE173374

Sample

Accession:: GSM6257275

ID:: 306257275

SRA Run Selector

Select item 3062572748.

HEK293 siTHOC2 Nanopore

Organism:: Homo sapiens

Source name:: kidney

Platform:: GPL24106
Series:: GSE173374

Sample

Accession:: GSM6257274

ID:: 306257274

SRA Run Selector

Select item 3062572739.

HEK293 siCtrl Nanopore

Organism:: Homo sapiens

Source name:: kidney

Platform:: GPL24106
Series:: GSE173374

Sample

Accession:: GSM6257273

ID:: 306257273

SRA Run Selector

Select item 30625727210.

HEK293 shTHOC5-2 Nanopore

Organism:: Homo sapiens

Source name:: kidney

Platform:: GPL24106
Series:: GSE173374

Sample

Accession:: GSM6257272

ID:: 306257272

SRA Run Selector

Select item 30625727111.

HEK293 shTHOC5-1-repeat Nanopore

Organism:: Homo sapiens

Source name:: kidney

Platform:: GPL24106
Series:: GSE173374

Sample

Accession:: GSM6257271

ID:: 306257271

SRA Run Selector

Select item 30625727012.

HEK293 shCtrl-repeat Nanopore

Organism:: Homo sapiens

Source name:: kidney

Platform:: GPL24106
Series:: GSE173374

Sample

Accession:: GSM6257270

ID:: 306257270

SRA Run Selector

Select item 30526667713.

HEK293 shTHOC5-1 Nanopore

Organism:: Homo sapiens

Source name:: Human embryonic kidney 293 cells

Platform:: GPL24106
Series:: GSE173374

Sample

Accession:: GSM5266677

ID:: 305266677

SRA Run Selector

Select item 30526667614.

HEK293 shCtrl Nanopore

Organism:: Homo sapiens

Source name:: Human embryonic kidney 293 cells

Platform:: GPL24106
Series:: GSE173374

Sample

Accession:: GSM5266676

ID:: 305266676

SRA Run Selector

Select item 30625729515.

HEK293 shTHOC5-40min TT-Seq

Organism:: Homo sapiens

Source name:: kidney

Platform:: GPL16791
Series:: GSE173374

Download data: BIGWIG

Sample

Accession:: GSM6257295

ID:: 306257295

SRA Run Selector

Select item 30625729416.

HEK293 shTHOC5-30min TT-Seq

Organism:: Homo sapiens

Source name:: kidney

Platform:: GPL16791
Series:: GSE173374

Download data: BIGWIG

Sample

Accession:: GSM6257294

ID:: 306257294

SRA Run Selector

Select item 30625729317.

HEK293 shTHOC5-20min TT-Seq

Organism:: Homo sapiens

Source name:: kidney

Platform:: GPL16791
Series:: GSE173374

Download data: BIGWIG

Sample

Accession:: GSM6257293

ID:: 306257293

SRA Run Selector

Select item 30625729218.

HEK293 shTHOC5-10min TT-Seq

Organism:: Homo sapiens

Source name:: kidney

Platform:: GPL16791
Series:: GSE173374

Download data: BIGWIG

Sample

Accession:: GSM6257292

ID:: 306257292

SRA Run Selector

Select item 30625729119.

HEK293 shCtrl-40min TT-Seq

Organism:: Homo sapiens

Source name:: kidney

Platform:: GPL16791
Series:: GSE173374

Download data: BIGWIG

Sample

Accession:: GSM6257291

ID:: 306257291

SRA Run Selector

Select item 30625729020.

HEK293 shCtrl-30min TT-Seq

Organism:: Homo sapiens

Source name:: kidney

Platform:: GPL16791
Series:: GSE173374

Download data: BIGWIG

Sample

Accession:: GSM6257290

ID:: 306257290

SRA Run Selector

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