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Items: 9

1.

Comparison of DNMT1 inhibitors by methylome profiling identifies unique signature of 5-aza-2'deoxycytidine [methylation]

(Submitter supplied) Dacogen (DAC/ 5-aza-2’deoxycitidine/Aza) is currently used to treat myeloid dysplastic syndrome (MDS) and is in trials for Acute Myeloid Leukaemia (AML) and some solid cancers. As a hypomethylating agent it is thought to act by inhibiting the enzymes which add methyl groups to DNA, chief among them DNMT1. Improved targeting has been hindered by a lack of understanding of the off-target effects following treatment. more...
Organism:
Homo sapiens
Type:
Methylation profiling by array
Platform:
GPL13534
7 Samples
Download data: IDAT, TXT
Series
Accession:
GSE104359
ID:
200104359

PubMed Similar studies Analyze with GEO2R

2.

Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)

(Submitter supplied) 1 difference between HumanMethylation450_15017482_v.1.1.bpm and HumanMethylation450_15017482_v.1.2.bpm: 1.1: 41636384,NEGATIVE,-99,Negative 604 1.2: 41636384,RESTORATION,Green,Restore Protocol: See manufacturer's website
Organism:
Homo sapiens
1686 Series
1 Related Platform
119315 Samples
Download data: BPM, CSV, TXT, XLSX
Platform
Accession:
GPL13534
ID:
100013534

3.

DNMT1_siRNA_2

Organism:
Homo sapiens
Source name:
hTERT
Platform:
GPL13534
Series:
GSE104359 GSE104361
Download data: IDAT
Sample
Accession:
GSM2796037
ID:
302796037

4.

DNMT1_siRNA

Organism:
Homo sapiens
Source name:
hTERT
Platform:
GPL13534
Series:
GSE104359 GSE104361
Download data: IDAT
Sample
Accession:
GSM2796036
ID:
302796036

5.

Aza_1

Organism:
Homo sapiens
Source name:
hTERT
Platform:
GPL13534
Series:
GSE104359 GSE104361
Download data: IDAT
Sample
Accession:
GSM2796035
ID:
302796035

6.

Aza

Organism:
Homo sapiens
Source name:
hTERT
Platform:
GPL13534
Series:
GSE104359 GSE104361
Download data: IDAT
Sample
Accession:
GSM2796034
ID:
302796034

7.

WT_3

Organism:
Homo sapiens
Source name:
hTERT
Platform:
GPL13534
Series:
GSE104359 GSE104361
Download data: IDAT
Sample
Accession:
GSM2796033
ID:
302796033

8.

WT_2

Organism:
Homo sapiens
Source name:
hTERT
Platform:
GPL13534
Series:
GSE104359 GSE104361
Download data: IDAT
Sample
Accession:
GSM2796032
ID:
302796032

9.

WT_1

Organism:
Homo sapiens
Source name:
hTERT
Platform:
GPL13534
Series:
GSE104359 GSE104361
Download data: IDAT
Sample
Accession:
GSM2796031
ID:
302796031

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