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Items: 14

1.

Discovery of naturally occurring ESR1 mutations during acquisition of resistance to endocrine therapy in widely used estrogen receptor positive breast cancer cell lines [ChIP-Seq]

(Submitter supplied) We report the first discovery of naturally occurring ESR1Y537C and ESR1Y537S mutations in MCF7 and MCF7 ESR1-positive cell-lines after acquisition of resistance to long-term-estrogen-deprivation (LTED) and subsequent resistance to fulvestrant (ICIR).
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL18573
12 Samples
Download data: XLS
Series
Accession:
GSE100074
ID:
200100074
2.

Illumina NextSeq 500 (Homo sapiens)

Platform
Accession:
GPL18573
ID:
100018573
3.

SUM44_Input_LTED

Organism:
Homo sapiens
Source name:
breast cancer cell line
Platform:
GPL18573
Series:
GSE100074 GSE100076
Download data
Sample
Accession:
GSM2670873
ID:
302670873
4.

SUM44_Input_WT

Organism:
Homo sapiens
Source name:
breast cancer cell line
Platform:
GPL18573
Series:
GSE100074 GSE100076
Download data
Sample
Accession:
GSM2670872
ID:
302670872
5.

SUM44_LTED_repl2

Organism:
Homo sapiens
Source name:
breast cancer cell line
Platform:
GPL18573
Series:
GSE100074 GSE100076
Download data: XLS
Sample
Accession:
GSM2670871
ID:
302670871
6.

SUM44_LTED_repl1

Organism:
Homo sapiens
Source name:
breast cancer cell line
Platform:
GPL18573
Series:
GSE100074 GSE100076
Download data: XLS
Sample
Accession:
GSM2670870
ID:
302670870
7.

SUM44_wt_repl2

Organism:
Homo sapiens
Source name:
breast cancer cell line
Platform:
GPL18573
Series:
GSE100074 GSE100076
Download data: XLS
Sample
Accession:
GSM2670869
ID:
302670869
8.

SUM44_wt_repl1

Organism:
Homo sapiens
Source name:
breast cancer cell line
Platform:
GPL18573
Series:
GSE100074 GSE100076
Download data: XLS
Sample
Accession:
GSM2670868
ID:
302670868
9.

MCF7 Input LTED_ESR1_Mut

Organism:
Homo sapiens
Source name:
breast cancer cell line
Platform:
GPL18573
Series:
GSE100074 GSE100076
Download data
Sample
Accession:
GSM2670867
ID:
302670867
10.

MCF7 Input_LTED_WT

Organism:
Homo sapiens
Source name:
breast cancer cell line
Platform:
GPL18573
Series:
GSE100074 GSE100076
Download data
Sample
Accession:
GSM2670866
ID:
302670866
11.

MCF7 Input_WT

Organism:
Homo sapiens
Source name:
breast cancer cell line
Platform:
GPL18573
Series:
GSE100074 GSE100076
Download data
Sample
Accession:
GSM2670865
ID:
302670865
12.

MCF7_LTED_MUT

Organism:
Homo sapiens
Source name:
breast cancer cell line
Platform:
GPL18573
Series:
GSE100074 GSE100076
Download data: XLS
Sample
Accession:
GSM2670864
ID:
302670864
13.

MCF7_LTED_WT

Organism:
Homo sapiens
Source name:
breast cancer cell line
Platform:
GPL18573
Series:
GSE100074 GSE100076
Download data: XLS
Sample
Accession:
GSM2670863
ID:
302670863
14.

MCF7_WT

Organism:
Homo sapiens
Source name:
breast cancer cell line
Platform:
GPL18573
Series:
GSE100074 GSE100076
Download data: XLS
Sample
Accession:
GSM2670862
ID:
302670862
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Supplemental Content

db=gds|term=GSE100074[Accession]|query=1|qty=2|blobid=MCID_679dfc1b2caaa62c628173d5|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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