GEO DataSets

(Submitter supplied) Global definition of androgen and anti-androgen effects on LNCaP transcriptomes using Affymetrix U133A oligonucleotide microarray. LNCaP in androgen-depleted medium was treated with androgen (DHT) and anti-androgen (CPA) for different time points (2 hours, 4 hours, 8 hours, and 24 hours). Untreated or Vehicle (Ethanol) treated samples as control.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

22 Samples

Download data

(Submitter supplied) Three isogenic HNC cell sublines with highly invasive properties were established. Invasion-associated genes were identified by comparison of transcriptomic profiles between HNC parental cell lines and the invasive sublines via Affymetrix cDNA microarrays. We used cDNA microarray to compare gene expression of invasion subline cells and parental cells in head and neck cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

12 Samples

Download data: CEL

(Submitter supplied) Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer, with approximately 50% of patients having residual disease after neoadjuvant chemotherapy (NACT) and worse prognosis with higher residual cancer burden (RCB). Patient-derived xenograft (PDX) models of breast cancer are an effective discovery platform and tool for preclinical pharmacologic testing and biomarker identification. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

207 Samples

Download data: CEL

(Submitter supplied) Delayed graft function (DGF) is associated with a reduced long-term graft survival. Ischemia-reperfusion damage and donors' features have been always considered as key pathogenic factors in this setting. The aim of our study was to evaluate the role of recipients' characteristics in the development of DGF to discover early genomics biomarkers in peripheral blood mononuclear cells (PBMC) in order to identify patients at risk. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

10 Samples

Download data: CEL

(Submitter supplied) Osteoarthritis causes pain and functional disability for over 500 million people worldwide and characterized by progressive loss of cartilage from the articulating surfaces of diarthrodial joints. Although the etiology of the disease is unknown, it is widely accepted that these degenerative changes arise from an imbalance of synthetic and degradative pathways that control cartilage extracellular matrix metabolism. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

11 Samples

Download data: CEL, CHP

(Submitter supplied) The generation of blood cells in the hematopoietic microenvironment requires support from mesenchymal cells. We found that stably growing cell populations derived from individually sorted human bone marrow mesenchymal cells immortalized by enforced expression of hTERT comprised both supportive and non-supportive clones. We compared gene expression of supportive and non-supportive clones to identify genes associated with the growth supportive capacity of mesenchymal cells Keywords: Cell type comparison

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

7 Samples

Download data: CEL

(Submitter supplied) In order to investigate the effect of in vitro hyperglycemia on gene expression of fpEC, cells were treated with hypergylcemia (25mM) for 24h.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

2 Samples

Download data: CEL, CHP

(Submitter supplied) Psoriasis was found to ameliorate multiple sclerosis (MS) outcomes when it MS onset. However, the molecular basis for this observation remains unclear. Herein, we compared the blood mononuclear cell transcriptome of psoriasis and MS comorbide (P/MS) patients with that of patients with either psoriasis or MS to understand the clinical observation.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL96 GPL571

55 Samples

Download data: CEL, XLS, XLSX

(Submitter supplied) Interferons are crucial for adaptive immunity and play an important role in the immune landscape of breast cancer. Using microarray-based gene expression analysis, we examined the subtype specific prognostic significance of interferon-γ (IFN-γ) as a single gene as well as an IFN-γ signature covering the signaling pathway in 461 breast cancer patients. Prognostic significance of IFN-γ as well as the IFN-γ signature for metastasis-free survival (MFS) were examined using Kaplan Meier as well as univariate and multivariate Cox regression analyses in the whole cohort and in different molecular subtypes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

461 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Rattus norvegicus; Homo sapiens

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL10352 GPL1355 GPL96

27 Samples

Download data: CEL, TXT

(Submitter supplied) The differential expression of microRNAs in Ras transformed epithelial cells of human and rat origin was investigated. Here we describe the group of miRNAs differentially expressed in two Ras transformed cell lines and defined it as a miRNA Ras signatures. We show that expression of these miRNAs are also affected in different primary tumors with high frequency of Ras mutation. We demonstate that introduction of different miRNAs lost during Ras transformation have big influence on cellular phenotype and mRNA expression. more...

Organism:

Homo sapiens; Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL96 GPL1355

15 Samples

Download data: CEL

(Submitter supplied) We examined feasibility of a unique approach towards gaining insight into heritable risk for early atherosclerosis: surveying gene expression by endothelial cells from living subjects. Subjects <50 years old (mean 37, range 22-49) without obstructive coronary artery disease underwent coronary reactivity testing that identified them as having normal (NL) or abnormal (ABNL) coronary endothelial function. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

19 Samples

Download data: CEL

(Submitter supplied) Most information on molecular processes accompanying and driving adipocyte differentiation are derived from rodent models. Here, a comprehensive analysis of combined transcriptomic and proteomic alterations during adipocyte differentiation in Simpson–Golabi–Behmel Syndrome (SGBS) cells is provided. The SGBS cells are a well-established and the most widely applied cell model to study human adipocyte differentiation and cell biology. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

13 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

4 related Platforms

452 Samples

Download data: CEL

(Submitter supplied) MicroRNAs are considered to be essential regulators during post-transcription in gene expression that mainly through repression mechanism to regulate target mRNAs. We generate expression data from profiling of 664 miRNA in 113 paired tumors and non-tumors of esophageal squamous carcinoma (ESCC), along with matched genome-wide mRNA gene expression data and extensive analysis association study with clinical viable. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL96 GPL571 GPL570

226 Samples

Download data: CEL, TXT

(Submitter supplied) High-grade serous ovarian carcinoma (HGSOC) is generally associated with a very dismal prognosis. Nevertheless, patients with similar clinicopathological characteristics can have markedly different clinical outcomes. Our aim was the identification of novel molecular determinants influencing survival. Gene expression profiles of 12 HGSOC long-term and 27 short-term survivors (training set) were generated by microarray, and a prognostic signature was identified and further evaluated on an independent extensive HGSOC dataset through a meta-analysis approach.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL96 GPL570

39 Samples

Download data: CEL, XLSX

(Submitter supplied) The series represent gene expression profiles of HMT3522 S1 mammary epithelial cells cultured as 2D monolayers or in 3D reconstituted basement membrane (rBM) and treated with the death ligand TRAIL. Keywords: Genetic modification; response to death induction

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

12 Samples

Download data: CEL, CHP

(Submitter supplied) Expression profiling of human myositis muscle samples This study was designed to compare expression signatures among the various types of inflammatory myopathy, dermatomyositis (DM), inclusion body myositis (IBM), necrotizing myopathy (NM), nonspecific myopathy (NS), and polymyositis (PM) compared to normal (NL) muscle.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

77 Samples

Download data: CEL

(Submitter supplied) We expressed either only the E7 oncoprotein or the complete early genome region (CER) of the human papillomavirus type 8 in primary human adult skin keratinocytes. Cells were retrovirally transduced, selected, and cellular mRNA was extracted after expansion of the transgene positive keratinocytes.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

9 Samples

Download data: CEL, CHP

(Submitter supplied) 63 samples were profiled in replicates on Affymetrix microarrays and using a custom RNASeq panel. The samples were randomly split in a training and validation cohort. SET ER/PR was calculated and a linear model was trained and validated to reproduce values obtained by microarray using RNASeq. In addition, the microarray replicates were used to validate the technical reproducibility of SET ER/PR.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

128 Samples

Download data: CEL