GEO DataSets

(Submitter supplied) Transcriptomes of 24 clinical strains of E. coli O157:H7 that differ phylogenetically and by Shiga toxin profiles were compared after 30 min co-incubation with epithelial cells.

Organism:

Escherichia coli

Type:

Expression profiling by array

Platform:

GPL7445

36 Samples

Download data: GPR

(Submitter supplied) Transcriptional profiling of E. coli DH5alpha cells comparing control untreated cells with cells exposed to sublethal concentrations of reuterin (3-hydroxypropionaldehyde).

Organism:

Escherichia coli DH5[alpha]; Escherichia coli

Type:

Expression profiling by array

Platform:

GPL7445

5 Samples

Download data: GPR

(Submitter supplied) Two outbreak strains of E. coli O157:H7 differ phylogenetically, in gene content, and in epidemiological characteristics. The working hypothesis in this experiment was that these strains will also differ in the transcription of shared virulence genes. Indeed, following a 30 minute exposure to epithelial cells, strain TW14359 overexpressed major and ancillary virulence genes, relative to strain Sakai.

Organism:

Escherichia coli

Type:

Expression profiling by array

Platform:

GPL7445

1 Sample

Download data: GPR

(Submitter supplied) There is increasing evidence to support a role for sigma factor 54 (RpoN) in the regulation of stress resistance factors and protein secretion systems important to bacterial transmission and pathogenesis. In enterohemorrhagic E. coli O157:H7, acid resistance and type III secretion are essential determinants of gastric passage and colonization. This study thus described the transcriptome of an rpoN null strain of E. more...

Organism:

Escherichia coli; Escherichia coli O157:H7 str. Sakai

Type:

Expression profiling by array

Platform:

GPL7445

8 Samples

Download data: GPR

(Submitter supplied) Escherichia coli O157:H7 strains have been classified into different genotypes based on the presence of specific shiga toxin-encoding bacteriophage insertion sites. Genotypes that are predominant in clinical isolates are named clinical genotypes and those that are isolated mostly from bovine sources are bovine-biased genotypes. To determine whether inherent differences in gene expression could possibly explain the variation in infectivity of these genotypes, we compared the expression patterns of O157:H7 strains isolated from cattle, which belonged to either clinical genotype 1 or bovine-biased genotype 5. more...

Organism:

Escherichia coli

Type:

Expression profiling by array

Platform:

GPL7445

16 Samples

Download data: GPR

(Submitter supplied) Integrating laterally acquired virulence genes into the backbone regulatory network is important for the pathogenesis of Escherichia coli O157:H7, which has captured many virulence genes through horizontal transfer during evolution. GadE is an essential transcriptional activator of glutamate decarboxylase (GAD) system, the most efficient acid resistance mechanism in E. coli. The full contribution of GadE to the acid resistance and virulence of pathogenic E. more...

Organism:

Escherichia coli

Type:

Expression profiling by array

Platform:

GPL7445

20 Samples

Download data: GPR