GEO DataSets

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

115 Samples

Download data: CEL

(Submitter supplied) Host gene expression responses can be used to determine the etiology of acute infection. PBMCs were stimulated with bacterial, viral, and fungal stimuli and then analyzed for differential gene expression utilizing microarrays to derive pathogen class-specific gene expression classifiers of infection. Validation Cohort: peripheral blood samples of human patients with acute viral, bacterial, or fungal infections

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

61 Samples

Download data: CEL

(Submitter supplied) Host gene expression responses can be used to determine the etiology of acute infection. PBMCs were stimulated with bacterial, viral, and fungal stimuli and then analyzed for differential gene expression utilizing microarrays to derive pathogen class-specific gene expression classifiers of infection. Discovery Cohort: In vitro human PBMC challenges were performed with bacteria (gram postive and gram negative), viruses (4 strains of influenza), and fungi (Cryptococcus and Candida)

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

54 Samples

Download data: CEL

(Submitter supplied) The more aggressive clinical disease course of Pediatric Onset Multiple Sclerosis(POMS) as compared to Adult Onset Multiple Sclerosis(AOMS) during the first year disease is supported by higher inflammatory potential promoted by transcriptional level of age-associated genes and transcription factors involved in Cell Cycle, B Cell proliferation and senescent mechanisms. Herein, we compared the blood mononuclear cell transcriptome of POMS and AOMS patients during first year disease. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

59 Samples

Download data: CEL

(Submitter supplied) Background: Chaperon-mediated autophagy (CMA) has taken on a new emphasis in cancer biology. However, the roles of CMA in hypoxic tumours are poorly understood. We investigated the anti-tumour effects of the natural product ManA through the activation of CMA in tumour progression under hypoxia. Methods: The effect of ManA on CMA activation was assessed in mouse xenograft models and cells. The gene expressions of HIF-1α, HSP90AA1, and transcription factor EB (TFEB) were analysed using The Cancer Genome Atlas (TCGA) datasets to assess the clinical relevance of CMA. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

12 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:

GPL24676 GPL20301 GPL571

107 Samples

Download data: BEDGRAPH, CEL, NARROWPEAK

(Submitter supplied) Unsupervised clustering of desmoid tumors and normal mesenchymal tissues was performed using henes associated with HIF1 activity. This accurately distiguished neoplastic tissues from normal controls The study sought to identify genes differentially expressed in desmoid-type fibromatosis as opposed to normal mesenchymal tissues. We noted that beta-catenin, the central driver in desmoid-type fibromatosis, appeared to regulate HIF1 signaling in in vitro studies. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

85 Samples

Download data: CEL

(Submitter supplied) We introduce AI method for addressing batch effect of genetic data The method does not rely on any assumptions regarding the distribution and the behavior of data elements. Hence, it does not introduce any new biases in the process of correcting for batch effect. It strictly maintains the integrity of measurements within the original batches.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

216 Samples

Download data: CEL

(Submitter supplied) The autoimmune disease lupus erythematosus (lupus) is characterized in part by photosensitivity, where patients can develop inflammatory skin lesions with even ambient ultraviolet radiation (UVR) exposure. Evidence points to a role for type I interferon (IFN-I) in photosensitivity, but mechanistic understanding remains limited. We have shown that photosensitivity in lupus models is at least in part attributable to Langerhans cell (LC) dysfunction. more...

Organism:

Homo sapiens

Type:

Expression profiling by array; Third-party reanalysis

Platform:

GPL571

14 Samples

Download data: CEL, TXT

(Submitter supplied) All organisms are exposed to various stresses, necessitating adaptive strategies for survival and homeostasis. In bacteria, the main stress-coping mechanism is stringent response triggered by the accumulation of the “alarmone” (p)ppGpp to trigger proliferation arrest and transcriptional reprogramming. Mammalian genomes encode MESH1  —the homologue of the (p)ppGpp hydrolase SpoT, with unknown function. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

12 Samples

Download data: CEL

(Submitter supplied) TAZ is an important transcriptional co-activator involved in the HIPPO pathway that regulates cell growth, tumorigenesis and organ development and can play as a key mediator in other signaling pathways, such as MESH1-regulated pathways. MESH1 is the human ortholog of spoT that regulates sringent response in bacteria. MESH1 silencing inhibits cell proliferation and triggers a genome-wide transcriptional reprogramming as how spoT works in bacteria, among which TAZ is significantly down-regulated. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

12 Samples

Download data: CEL

(Submitter supplied) Donor organ shortage, growing waiting lists and organ discard rates are key problems in kidney transplantation. Donor organ quality is a critical factor determining post-transplant graft outcomes. However, organ quality is difficult to predict. Balancing the use of marginal donors without affecting outcomes is a main issue in the transplant field. The decision of acceptance of a kidney organ for transplantation is mainly based on donor organ biopsy findings, even though there are recognized limitations. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

192 Samples

Download data: CEL

(Submitter supplied) Expression data of Glioma Stem Cells sorted for CD133 and PDPN expression.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

14 Samples

Download data: CEL

(Submitter supplied) All organisms are constantly exposed to various stresses, necessitating adaptive strategies for survival. In bacteria, the main stress-coping mechanism is the stringent response triggered by the accumulation of “alarmone” (p)ppGpp to arrest proliferation and reprogram transcriptome. While mammalian genomes encode MESH1—the homolog of the (p)ppGpp hydrolase SpoT, current knowledge about its function remains limited. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

9 Samples

Download data: CEL

(Submitter supplied) Type 1 adenylyl cyclase (ADCY1) is a main enzyme to produce cyclic AMP (cAMP) upon activation of G-protein coupled receptors and increase of intracellular calcium. It regulates cAMP signaling and in turn affects physiological functions including neural plasticity, cognition, motor function, cell survival, and neuropathic pain. We used microarrays to determine the effect of a known ADCY1 inhibitor NB001 on gene transcription.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

4 Samples

Download data: CEL

(Submitter supplied) MESH1 encodes for Metazoan SpoT Homolog 1, which is a homologue of bacterial SpoT that mediates bacterial stringent response. In human cells, we found that MESH1-silencing induces an extensive transcriptional response in clear cell carcinoma cell line RCC4 that partially overlap with mammalian cell integrated stress response (ISR), which ATF4 up-regulation is an essential branch of the response. In this study, the goal is to elucidate the role of ATF4 up-regulation in MESH1-silencing transcriptional response.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

12 Samples

Download data: CEL

(Submitter supplied) Calcineurin inhibitor nephrotoxicity (CNIT) has been associated with the development of chronic renal allograft dysfunction and decreased graft survival. This study evaluated 37 formalin-fixed paraffin-embedded biopsies from pediatric kidney transplant recipients using gene expression profiling. Oxidative phosphorylation and mitochondrial dysfunction were the top molecular pathways as-sociated with overexpressed genes in CNIT samples. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

37 Samples

Download data: CEL

(Submitter supplied) There are regional differences in plaque morphology and mechanistic differences between areas upstream and downstream of the lipid core. Transcript expression profiles were determined for post-bifurcation carotid plaques to identify genes differentially expressed between symptomatic and asymptomatic patients.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

18 Samples

Download data: CEL

(Submitter supplied) Previously, we developed a new model of diabetes-induced wound healing impairment in skin-humanized mice models that faithfully recapitulates the major histo-physiological features of such skin repair-deficient condition. Aiming to dissect the molecular mechanisms responsible for the delayed wound closure, global gene expression studies were performed.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

26 Samples

Download data: CEL, CHP

(Submitter supplied) Pediatric MS patients suffer from severe first and second relapse but better recovery explained by difference in age-restricted transcriptional profiles associated with antigen-presentation and B-cell activation Herein, we compared the blood mononuclear cell transcriptome of pediatric and adult MS patients with recovery (PDMS-rec, ADMS-rec) and without recovery (PDMS-norec, ADMS-norec) 6 months after relapse. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

85 Samples

Download data: CEL