GEO DataSets

(Submitter supplied) Changes in gene regulation have long been though to underlie most phenotypic differences between species. Subterranean rodents, and in particular the naked mole-rat (NMR), have attracted substantial attention due to their proposed phenotypic adaptations, which include hypoxia tolerance, metabolic changes and cancer resistance. However, it is largely unknown what regulatory changes may associate with these phenotypic traits, and whether these are unique to the NMR, the mole-rat clade or also present in other mammals. more...

Organism:

Mus musculus; Fukomys damarensis; Heterocephalus glaber; Cavia porcellus

Type:

Genome binding/occupancy profiling by high throughput sequencing; Other

13 related Platforms

160 Samples

Download data: NARROWPEAK, WIG

(Submitter supplied) We sequenced polyA-selected RNA from bone marrow derived cells from 47 bone samples collected from 16 captive, adult female Damaraland mole-rats (Fukomys damarensis). The 16 females were experimentally manipulated to either remain as nonbreeders (either as helpers or solitaires) or become breeders, and breeding status was maintained for over 1 year prior to tissue collection and cell culture. A subset of cultured cells were treated for 24 hours with 10 nM estradiol prior to sample collection.

Organism:

Fukomys damarensis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28700

47 Samples

Download data: TXT