GEO DataSets

(Submitter supplied) Purpose: Small bowel adenocarcinoma (SBA) is a rare cancer and consequently the number of clinical trials has been very limited due to the small numbers of patients. Chemotherapy regimens are currently rather arbitrarily chosen between either a colorectal (CRC) or a gastric cancer (GC) regimen. Chromosomal copy number aberrations are a hallmark of solid tumours and can be measured by array comparative genomic hybridization (aCGH). more...

Organism:

Homo sapiens

Type:

Genome variation profiling by array; Genome variation profiling by genome tiling array

11 related Platforms

91 Samples

Download data: TXT

(Submitter supplied) Bortezomib is a proteasome inhibitor used in severel different hematological malignancies. Resistance to this drug is still poorly understood. In order get more insight in the resistance mechanism, we developed several bortezomib resistant subclones of the THP-1 monocytic/macrophage cell line. On these subclones expression arrays were performed.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2827

3 Samples

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(Submitter supplied) Background: The spatial organisation of the genome in the nucleus has a role in the regulation of gene expression. In mammals, chromosomal regions with low gene-density are located close to the nuclear periphery. Correlations have also been made between the transcriptional state of some genes and their location near the nuclear periphery. However, a crucial issue is whether this level of nuclear organisation directly affects gene function, rather than merely reflecting it. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2827

13 Samples

Download data: TXT

(Submitter supplied) Experiment: analysis of gene expression changes between J21.c3 (non tethered) vs J21.c3 lacI-lap2b (lap2b-lacI tethered) that both possess a Chr11 128mer LacO integrant Keywords: comparative hybridization to access expression profiles between tethered and non tethred cells.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2827

5 Samples

Download data: TXT, XLS

(Submitter supplied) Experiment: analysis of gene expression changes between B49.5 (non tethered) vs B49.5 74t3 (lap2b-lacI tethered) that both possess a Chr4 128mer LacO integrant Keywords: comparative hybridization to access expression profiles between tethered and non tethred cells.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2827

4 Samples

Download data: TXT, XLS

(Submitter supplied) a- Self –Self Hybridisation were used to set confidence 99% interval using RNA from non-tethered cell lines that is both labelled in with cy3 cy5 (theoretically identical cDNA populations) to compared technical errors associated with such experiments Keywords: comparative hybridization to access expression profiles between Cy3 and Cy5 uniformally labelled template.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2827

4 Samples

Download data: TXT, XLS

(Submitter supplied) Understanding the molecular events in non-small cell lung cancer (NSCLC) is essential to improve early diagnosis and treatment for this disease. We examined the effect of chromosomal copy number changes on gene expression in resected NSCLC patients. We identified a deletion on 14q32.2-33 as a common alteration in NSCLC (44%), which significantly influenced gene expression for HSP90AA1, residing on 14q32. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by array

Platform:

GPL2827

32 Samples

Download data: XLS

(Submitter supplied) Array-based comparative genomic hybridisation is a high-resolution method for measuring chromosomal copy number changes. Here we present a validated protocol using in-house spotted oligonucleotide libraries for array CGH. This oligo array CGH platform yields reproducible results and is capable of detecting single copy gains, multi-copy amplifications as well as homozygous and heterozygous deletions as small as 100 kb with high resolution. more...

Organism:

Homo sapiens; Mus musculus

Type:

Genome variation profiling by array; Genome variation profiling by genome tiling array

11 related Platforms

36 Samples

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