GEO DataSets

(Submitter supplied) Changes in gene regulation have long been though to underlie most phenotypic differences between species. Subterranean rodents, and in particular the naked mole-rat (NMR), have attracted substantial attention due to their proposed phenotypic adaptations, which include hypoxia tolerance, metabolic changes and cancer resistance. However, it is largely unknown what regulatory changes may associate with these phenotypic traits, and whether these are unique to the NMR, the mole-rat clade or also present in other mammals. more...

Organism:

Mus musculus; Fukomys damarensis; Heterocephalus glaber; Cavia porcellus

Type:

Genome binding/occupancy profiling by high throughput sequencing; Other

13 related Platforms

160 Samples

Download data: NARROWPEAK, WIG

(Submitter supplied) Naked mole rats (NMRs, Heterocephalus glaber) are long-lived mammals that possess a natural resistance to cancer and other age-related pathologies, maintaining a healthy life span for >30 years. We report application of RNAseq technology to analyze changes in the skin transcriptome of NMRs during aging. RNAseq analyses reveal that the transcript levels of several longevity-associated (Igfbp3, Igf2bp3, Ing2) and tumor-suppressor genes (Btg2, Cdkn1a, Cdkn2c, Dnmt3a, Hic1, Socs3, Sfrp1, Sfrp5, Thbs1, Tsc1, Zfp36) are increased in aged versus young NMR skin. more...

Organism:

Heterocephalus glaber

Type:

Expression profiling by high throughput sequencing

Platform:

GPL26775

2 Samples

Download data: XLSX

(Submitter supplied) Single-cell RNA-sequencing was performed in the mouse and naked mole-rat immune systems in order to map and compare their immune cell repertoirs and their cell-specific gene-expression responses to LPS challenge

Organism:

Heterocephalus glaber; Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL21103 GPL26775

63 Samples

Download data: CSV