GEO DataSets

(Submitter supplied) COVID-19 vaccination is the most effective approach to prevent severe disease and death. Inactivated vaccines are the most accessible type of COVID-19 vaccines in the developing countries. Several studies, including work from our group, have demonstrated that the third (booster) dose of inactivated COVID-19 vaccine induces robust humoral and cellular immune responses. The aim of this study was to examine miRNA expression profile in participants received a homogenous third dose of the CoronaVac vaccine.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL24741

12 Samples

Download data: TXT

(Submitter supplied) The Coronavirus Disease 2019 (COVID-19) is mainly a respiratory syndrome that can affect multiple organ systems, causing a variety of symptoms. Among the most common and characteristic symptoms are deficits in smell and taste perception, which may last for weeks/months after COVID-19 diagnosis owing to mechanisms that are not fully elucidated. In order to identify the determinants of olfactory symptom persistence, we obtained olfactory mucosa (OM) from 21 subjects, grouped according to clinical criteria: i) with persistent olfactory symptoms; ii) with transient olfactory symptoms; iii) without olfactory symptoms; and iv) non-COVID-19 controls. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL24741

12 Samples

Download data: TXT

(Submitter supplied) To elucidate the mode of actions of Plumbagin and Menadione, miRNA-profilling was performed after treating cells with vehicle (DMSO), Plumbagin (10uM), and Menadione (10uM) for 24 hours. Threel replicates for control and Menadione and two replicates for Plumbagin were subjected to miRNA-microarray.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL24741

8 Samples

Download data: TXT

(Submitter supplied) Hypertrophic scar (HS) is a skin lesion due to abnormal wound healing after skin injury; histologically, HS is characterized by deposition of excessive amounts of the extracellular matrix and collagen produced by wound healing-induced proliferative fibroblasts. Clinically, HS management includes surgical resection of HS, topical glucocorticoid therapy or drug injections, pressure therapy, fractional carbon dioxide laser therapy, and cryotherapy. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL24741

6 Samples

Download data: TXT

(Submitter supplied) A previous study suggested that the expression of miR181a-5p was higher in CRC tissues, but whether CRC cell-derived exosomes regulate the activation of HSCs through secreting miR181a-5p and promoting CRLM warrants further investigation. We compared the miRNA expression profiles between exosomes from highly metastatic CRC cells (RKO and SW620) and those from weakly-metastatic CRC cells (HT29 and SW480).

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL24741

12 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platforms:

GPL24741 GPL22120

24 Samples

Download data: TXT

(Submitter supplied) we profiled whole transcriptome in depression patients’ and healthy volunteers blood samples via microarray analysis.Differentially expressed miRNAs were selected for deep analysis. Especially the Differentially expressed genes that associated with cancer

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL24741

12 Samples

Download data: TXT

(Submitter supplied) Background: Tumor stage predicts pancreatic cancer (PDAC) prognosis, but prolonged and short survivals have been described in patients with early-stage tumors. Circulating microRNA (miRNA) are an emerging class of suitable biomarkers for PDAC prognosis. Our aim was to identify whether serum miRNA signatures predict survival of early-stage PDAC. Methods: Se-rum RNA from archival 15 stage I-III PDAC patients and 4 controls was used for miRNAs ex-pression profile (Agilent microarrays). more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL24741

19 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL21185 GPL24741

16 Samples

Download data: TXT

(Submitter supplied) MicroRNAs are regulators of gene expression. A wide-spread, yet not validated, assumption is that the targetome of miRNAs is non-randomly distributed across the transcriptome but that targets share functional pathways. We developed a computational and experimental strategy termed high-throughput miRNA interaction reporter assay (HiTmIR) to facilitate the validation of target pathways. First, targets and target pathways are predicted and prioritized by computational means to increase the specificity and positive predictive value. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL24741

8 Samples

Download data: TXT

(Submitter supplied) Atherosclerosis (AS), which is a chronic inflammatory disease, is the leading cause of death worldwide. Although several miRNAs have been reported to participate in regulating the progression of AS, there is a lack of systematic study of miRNA profile in AS. We combined miRNA and mRNA array analysis to study the global miRNAs in two AS models-oxidative LDL treated human aortic endothelial cells (HAEC) and high fat diet fed ldlr W483Stop knockin mouse. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL24741

6 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing; Non-coding RNA profiling by array

Platforms:

GPL24741 GPL13497

79 Samples

Download data: TXT

(Submitter supplied) The human thymus shows a transient involution along the neonatal period and starts a continuous process of decline between the 1st and 2nd years. The immune alterations associated to thymic aging in humans have been extensively investigated, but the genomic mechanisms underlying this process remain largely unknown. Here we conducted a temporal gene co-expression network analysis in the newborn and infant thymic tissue aiming to identify transcriptional modules associated to age.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL24741

29 Samples

Download data: TXT

(Submitter supplied) Purpose: Gastric cancer (GC) is one of the most common causes of cancer deaths worldwide; however, reliable and non-invasive screening methods for GC are not established. Therefore, we conducted this study to develop a biomarker for GC detection, consisting of urinary microRNAs (miRNAs). Experimental Design: We matched 306 participants by age and sex (153 pairs consisting of patients with GC and healthy controls [HCs]), then randomly divided them across three groups: (1) the discovery cohort (4 pairs); (2) the training cohort (95 pairs); (3) the validation cohort (54 pairs). more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL24741

7 Samples

Download data: TXT

(Submitter supplied) The roles of microRNAs (miRNAs) in odontogenic differentiation of human dental pulp stem cells (hDPSCs) remain largely unexplored. In this study, the underlying molecular mechanism of osteogenic differentiation in hDPSCs is investigated using miRNA profifiling.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL24741

6 Samples

Download data: TXT

(Submitter supplied) We profiled the microRNA expression of 5 pairs of PTC and normal thyroid tissues. All the tissues were immediately snap-frozen in liquid nitrogen and confirmed as papillary thyroid carcinoma by expert pathologists. Numerous deregulated mature microRNAs were identified comparing PTC tissues versus normal thyroid tissues. Details about the clinical-pathological characteristics of the samples are also provided.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL24741

10 Samples

Download data: TXT

(Submitter supplied) Among the miRNAs regulated by IL-23, expression levels of 5 miRNAs were increased in T cells from patients with AS. The transfection of miR-29b-1-5p mimic could inhibit the IL-23-mediated STAT3 phosphorylation and might play a negative feedback control in the immunopathogenesis of AS.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL24741

6 Samples

Download data: TXT

(Submitter supplied) DNA-Double strand breaks (DSBs) generated by radiation therapy represent the most efficient lesions to kill tumor cells, however, the inherent DSB repair efficiency of tumor cells can cause cellular radioresistance and impact on therapeutic outcome. Genes of DSB repair represent a target for cancer therapy since their down-regulation can impair the repair process making the cells more sensitive to radiation. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL24741

16 Samples

Download data: TXT

(Submitter supplied) We analyzed the combination of ionizing radiation (IR, 2.0 Gy) along with microRNA-mediated targeting of genes involved in DSB repair to sensitize human non-small cell lung cancer (NSCLC) cells.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL24741

8 Samples

Download data: TXT

(Submitter supplied) We analyzed the combination of ionizing radiation (IR, 2.0 Gy) along with microRNA-mediated targeting of genes involved in DSB repair to sensitize human non-small cell lung cancer (NSCLC) cells.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL24741

8 Samples

Download data: TXT