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Items: 6

1.

The evolution of the naked mole-rat T cells

(Submitter supplied) The immune system consists of a network of specialized cells and processes that protect the organism from diseases and regulates tissue repair. Natural killer (NK) cells and the αβ and γδ T cells comprise the cytotoxic arm of the immune system and have evolved to detect and eradicate cells infected with pathogens and affected by malignancies, in order to prevent their spread and subsequent tissue damage. more...
Organism:
Heterocephalus glaber; Mus musculus
Type:
Expression profiling by high throughput sequencing
4 related Platforms
66 Samples
Download data: MTX, TSV
Series
Accession:
GSE214390
ID:
200214390
2.

Epigenomic analysis of regulatory evolution in mole rats

(Submitter supplied) Changes in gene regulation have long been though to underlie most phenotypic differences between species. Subterranean rodents, and in particular the naked mole-rat (NMR), have attracted substantial attention due to their proposed phenotypic adaptations, which include hypoxia tolerance, metabolic changes and cancer resistance. However, it is largely unknown what regulatory changes may associate with these phenotypic traits, and whether these are unique to the NMR, the mole-rat clade or also present in other mammals. more...
Organism:
Mus musculus; Fukomys damarensis; Heterocephalus glaber; Cavia porcellus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Other
13 related Platforms
160 Samples
Download data: NARROWPEAK, WIG
Series
Accession:
GSE222972
ID:
200222972
3.

Single cell transcriptomics of yound and aged naked mole-rat (NMR) epidermal cells

(Submitter supplied) Study the global transcriptional heterogeneity of young and aged NMR epidermis using scRNA-seq,
Organism:
Heterocephalus glaber
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24046
6 Samples
Download data: CSV
Series
Accession:
GSE152886
ID:
200152886
4.

Postnatal Oogenesis In the Naked Mole Rat

(Submitter supplied) The goal of this analysis is to compare the transcriptome profile (RNA-seq) along different developmental ages in the naked mole rat ovary
Organism:
Heterocephalus glaber
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24046
13 Samples
Download data: DIFF, GTF, TXT
Series
Accession:
GSE139515
ID:
200139515
5.

The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species [Bis-PCR: naked mole-rat]

(Submitter supplied) We used liver samples from Naked Mole Rat to determine rate of change of methylation with respect to age.
Organism:
Heterocephalus glaber
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL24046
24 Samples
Download data: TXT
Series
Accession:
GSE104215
ID:
200104215
6.

The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Heterocephalus glaber; Homo sapiens; Canis lupus familiaris; Macaca mulatta
Type:
Methylation profiling by high throughput sequencing; Methylation profiling by genome tiling array
Platforms:
GPL24046 GPL13534 GPL22370
84 Samples
Download data: TXT
Series
Accession:
GSE86059
ID:
200086059
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