GEO DataSets

(Submitter supplied) The RANGE study (NCT02426125) evaluated ramucirumab (an anti-VEGFR2 monoclonal antibody) in patients with platinum-refractory advanced urothelial carcinoma (UC). Here, we use programmed cell death-ligand 1 (PD-L1) immunohistochemistry (IHC) and transcriptome analysis to evaluate the association of immune and angiogenesis pathways, and molecular subtypes, with overall survival (OS) in UC. Higher PD-L1 IHC and immune pathway scores, but not angiogenesis scores, are associated with greater ramucirumab OS benefit. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL22995

394 Samples

Download data: CEL

(Submitter supplied) We performed a retrospective analysis of the SweBCG 91-RT trial, which randomized women with node-negative stage I-IIA breast cancer to whole breast radiotherapy or no radiotherapy following breast-conserving surgery with minimal use of adjuvant systemic treatment. Primary tumors were profiled with the GeneChip Human Exon 1.0 ST microarray.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL22995

765 Samples

Download data: CEL

(Submitter supplied) Neuroendocrine bladder cancer is an aggressive variant of bladder cancer with significant metastatic potential and high risk of mortality. Diagnosis of these tumors is currently dependent on morphological criteria and staining for neuroendocrine markers. Using machine learning and multiple validation cohorts in different clinical settings, we developed a model that identifies tumors with transcriptomic profiles consistent with NE bladder cancers with an absence of NE features by morphological criteria. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL22995

256 Samples

Download data: CEL

(Submitter supplied) Background: Bladder-sparing trimodality therapy (TMT) is an alternative to radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC), and biomarkers to inform therapy selection are needed. Objective: To evaluate immune and stromal signatures in MIBC treated with TMT.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL22995

136 Samples

Download data: CEL

(Submitter supplied) Despite cisplatin-based neoadjuvant chemotherapy (NAC) 60% of patients with muscle-invasive bladder cancer still have residual invasive disease at radical cystectomy (RC). The NAC-induced biological alterations in these cisplatin-resistant tumors remain largely unstudied. We analyzed gene expression from 133 patients with residual invasive disease after cisplatin-based NAC. H&E and immunohistochemistry were used to confirm tissue sampling and gene expression analysis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL22995

133 Samples

Download data: CEL

(Submitter supplied) Four different molecular classifications of muscle-invasive bladder cancer (MIBC) based on gene expression have been proposed. With the ultimate goal of utilizing these molecular subtypes for personalized treatment, we investigated their significance in the context of neoadjuvant cisplatin-based chemotherapy (NAC).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL22995

305 Samples

Download data: CEL

(Submitter supplied) See manufacturer's web site.

Organism:

Homo sapiens

6 Series

1 Related Platform

1989 Samples

Download data: TXT

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 Oct 11, 2012: annotation table updated with netaffx build 32 Protocol: See manufacturer's web site

Organism:

Homo sapiens

453 Series

35 Related Platforms

19794 Samples

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