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Items: 9

1.

iPSCs from patients with NBS as a model uncovering disease mechanisms and a screening platform for anti-oxidants modifying genomic stability

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL10558 GPL18405
19 Samples
Download data
Series
Accession:
GSE94708
ID:
200094708
2.

iPSCs from patients with NBS as a model uncovering disease mechanisms and a screening platform for anti-oxidants modifying genomic stability [fibroblasts]

(Submitter supplied) Nijmegen Breakage Syndrome (NBS) is a rare autosomal recessive genetic disorder, first described 1981 in Nijmegen, Holland. The characteristics of NBS include genomic instability (resulting in early onset of malignancies), premature aging, microcephaly and other growth retardations, immune deficiency, and impaired puberty and fertility in females. The consequence of these manifestations is a severe decrease in average life span, caused by cancer or infection of the respiratory and urinary tract. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL18405
8 Samples
Download data: TXT
Series
Accession:
GSE94706
ID:
200094706
3.

Mesenchymal Stromal Cells Derived from Human Embryonic Stem Cells, Fetal Limb and Bone Marrow Share a Common Phenotype but are Transcriptionally and Biologically Different

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL18405
136 Samples
Download data: IDAT
Series
Accession:
GSE100752
ID:
200100752
4.

Mesenchymal Stromal Cells Derived from Human Embryonic Stem Cells, Fetal Limb and Bone Marrow Share a Common Phenotype but are Transcriptionally and Biologically Different [II]

(Submitter supplied) Mesenchymal stromal cells (MSCs) can be obtained from several sources and the significant differences in their properties, makes it crucial to investigate the differentiation potential of MSCs from different sources to determine the optimal source of MSCs. We investigated if this biological heterogeneity in MSCs from different sources results in different mechanisms for their differentiation. In this study, we compared the gene expression patterns of phenotypically defined MSCs derived from three ontogenically different sources: Embryonic stem cells (hES-MSCs), Fetal limb (Flb-MSCs) and Bone Marrow (BM-MSCs). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL18405
56 Samples
Download data: IDAT, TXT
Series
Accession:
GSE100749
ID:
200100749
5.

Mesenchymal Stromal Cells Derived from Human Embryonic Stem Cells, Fetal Limb and Bone Marrow Share a Common Phenotype but are Transcriptionally and Biologically Different [I]

(Submitter supplied) Mesenchymal stromal cells (MSCs) can be obtained from several sources and the significant differences in their properties, makes it crucial to investigate the differentiation potential of MSCs from different sources to determine the optimal source of MSCs. We investigated if this biological heterogeneity in MSCs from different sources results in different mechanisms for their differentiation. In this study, we compared the gene expression patterns of phenotypically defined MSCs derived from three ontogenically different sources: Embryonic stem cells (hES-MSCs), Fetal limb (Flb-MSCs) and Bone Marrow (BM-MSCs). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL18405
80 Samples
Download data: IDAT, TXT
Series
Accession:
GSE100748
ID:
200100748
6.

Global expression analysis of the trabecular meshwork, cornea, sclera and trabecular meshwork-derived mesenchymal stem cells (TM-MSC)

(Submitter supplied) Microarray study comparing the trabecular meshwork (TM) with TM-MSC, corneal and scleral tissues
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL18405
12 Samples
Download data: TXT
Series
Accession:
GSE87526
ID:
200087526
7.

IRF4, a master transcription factor, regulates genes involved in BCR signaling, antigen processing and presentation, and GC development

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by genome tiling array; Expression profiling by array
Platforms:
GPL18405 GPL3787
5 Samples
Download data: GFF, IDAT
Series
Accession:
GSE64270
ID:
200064270
8.

IRF4, a master transcription factor, regulates genes involved in BCR signaling, antigen processing and presentation, and GC development [expression array]

(Submitter supplied) Interferon regulatory factor 4 (IRF4) is a master transcription factor required for the maturation of germinal center B cells that eventually develop into antibody secreting plasma cells and memory B cells. IRF4-deficient mice exhibit a profound reduction in serum immunoglobulin levels. In spite of wealth of the information relating to IRF4 and B cell biology, little is known about the intricate molecular details of the role of this transcription factor during B cell development. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL18405
2 Samples
Download data: IDAT, TXT
Series
Accession:
GSE64269
ID:
200064269
9.

Gene expression of T47D-MTVL human breast cancer cells upon H1.4 knock-down or overexpression

(Submitter supplied) Gene expression of T47D-MTVL human breast cancer cells expressing Dox-inducible shRNAs against histone H1.4 (sh120) or multiple H1 variants (sh225), or overexpressing WT or K26A mutant HA-tagged H1.4.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL18405
16 Samples
Download data: TXT
Series
Accession:
GSE55786
ID:
200055786
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