GEO DataSets

(Submitter supplied) miRNA profiling in HNSCC, including 66 paired normal, peritumor and tumor tissues from the same patients, and additional 55 unpaired tumor tissues

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platforms:

GPL8227 GPL16770

253 Samples

Download data: TXT

(Submitter supplied) HER2-positive (HER2+) breast cancer patients that do not respond to targeted treatment have a poor prognosis. The effects of targeted treatment on endogenous microRNA (miRNA) expression levels are unclear. We report that responsive HER2+ breast cancer cell lines had a higher number of miRNAs with altered expression after treatment with trastuzumab and lapatinib compared to poorly responsive cell lines. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL16770

48 Samples

Download data: TXT

(Submitter supplied) To investigate the function of the microRNAs involved in drug resistance in head and neck cancer, we overexpressed CD44s gene and GFP gene into oral squamous cancer cell line, SAS-3.4 cells. The phenotypes were analyzed and transcriptome of them were investigated.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL16770

6 Samples

Download data: TXT

(Submitter supplied) MicroRNAs (miRNAs) expression profiles are widely investigated in the major cancers, but their expression in patients plasmas of cancers have not yet to be fully elucidated. We investigated expression profiles of miRNAs in patients preoperative/postoperative plasmas of clear cell renal cell carcinomas (ccRCCs) by using a miRNAs microarray platform which covers a total of 1,523 human miRNAs.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL16770

10 Samples

Download data: TXT, XLSX

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL16770 GPL14550

72 Samples

Download data: TXT

(Submitter supplied) Expression microarray analyses was used to analyze 35 LSCC with reference sample of 5 normal tissue. A quality control filter was applied based on Feature Extraction flags (empty spaces replacing values)

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL16770

37 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL16699 GPL16770

28 Samples

Download data: TXT

(Submitter supplied) We performed integrated miRNA and mRNA expression profiling in blood samples of Marfan patients in order to investigate deregulated miRNA and mRNA networks in these patients which could serve as potential diagnostic and prognostic tools for MFS therapy.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL16770

14 Samples

Download data: TXT

(Submitter supplied) To determine the miRNAs’ roles in the tumorigenesis behavior of TNBC, we profiled the global miRNA expression in 2 highly aggressive TNBC cell lines (MDA-MB-231 and CAL-51) in comparison with that in 2 non-aggressive luminal-type breast cancer cell lines (ZR-75-1 and MCF-7).

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL16770

4 Samples

Download data: TXT

(Submitter supplied) We have employed miRNA microarray expression profiling to identify miRNAs that are differentially regulated by toll-like receptor activation in alveolar macrophages. Macrophages are strategically distributed all over the body and represent the first line of defense to invading pathogens. In response to bacterial or viral infections, these phagocytic cells engulf and destroy the infectious agent. Macrophages recognize a variety of microbial products, such as bacterial cell wall components and nucleic acids, via pathogen recognition receptors (PRRs), such as toll-like receptors (TLRs). more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL16770

24 Samples

Download data: TXT

(Submitter supplied) Proteomics analysis was conducted using sera from 31 OPLL patients and 17 healthy individuals, detecting a significantly defective protein in the former as compared with the latter. The continuous and mixed types of OPLL were compared, demonstrating a lower level of the protein in the former than the latter. Clinically, the continuous type, i.e., the ossification of the entire longitudinal ligament, was frequently detected in severe cases.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL16770

3 Samples

Download data: TXT

(Submitter supplied) Characterization of the tumor border microenvironment is critical for improving prognosis in patients with GBM. Here, we compared microRNA (miRNA) expression in samples from the tumor, tumor border, and peripheral region far from tumor mass by miRNA microarray. The top three of miRNAs showing higher expression in the tumor border were related to oligodendrocyte differentiation, and pathologically oligodendrocyte lineage cells were increased in the border, where numbers of macrophages and microglia also colocalized. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL16770

31 Samples

Download data: TXT

(Submitter supplied) Recent studies have revealed that microRNAs (miRNAs) participate in all steps of cancer initiation and progression by regulating protein coding genes at the post-transcriptional level. MiRNAs are in turn regulated by other genes, forming a complex regulatory network. The regulation networks between the p53 tumor suppressor and miRNAs in nasopharyngeal carcinoma (NPC) remain unclear. The aim of this study was to investigate the regulatory roles of the TP53 gene in regulating miRNA expression profiles in NPC cell line HNE2.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL16770

4 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Methylation profiling by genome tiling array; Non-coding RNA profiling by array

Platforms:

GPL16770 GPL16284 GPL16356

35 Samples

Download data: CEL, PAIR, TXT

(Submitter supplied) Valproic acid (VPA) is a very potent anti-cancer and neuro-protective drug. However, exposure to VPA may cause accumulation of lipids in the liver which could result in the development of steatosis. As VPA is a fatty acid analogue, most of the performed studies focus on inhibition of the mitochondrial b-oxidation pathway as the possible mode of action. However, investigations exploring the contribution of other processes in particular by using whole genome studies in a relevant human liver model are limited. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL16770

11 Samples

Download data: TXT

(Submitter supplied) To further identify the most significantly changed miRNA resulting from the different expression levels of TWIST2 in cervical cancer cells, we used a miRNA microarray to identify the miRNA expression profiles among SiHa, SiHa-tw2 and SiHa-shtw2. The significantly deregulated miRNAs (changes of more than 2-fold in expression) included miR-23b-5p, miR-221-3p, miR-502-3p, miR-221-5p, miR-15a-5p, miR-1227, miR-93-5p and miR-4257.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL16770

3 Samples

Download data: TXT

(Submitter supplied) Microarrays with 1,205 human microRNAs and 142 viral microRNAs were used for screening candidate diagnostic markers in the 3 categories of subjects from 24 plasma samples including acute aortic dissection, healthy and aortic aneurysm subjects. There were two microRNAs overlapping in the 3 group comparisons. Finally, 16 candidate microRNAs discovered via microarrays were selected for the further validation.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL16770

24 Samples

Download data: TXT

(Submitter supplied) To further understand the roles of miRNA during influenza A virus infection, we performed miRNA profiling in human alveolar adenocarcinoma cell lines, A549 cells, infected with influenza A virus A/Beijing/501/2009(H1N1) and A/goose/Jilin/hb/2003(H5N1).

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL16770

18 Samples

Download data: TXT

(Submitter supplied) To validate prediction marker of ovarian cancer patients, comprehensive analysis of serum microRNA of ovarian cancer patients were performed.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL16770

34 Samples

Download data: TXT

(Submitter supplied) Clear cell papillary renal cell carcinoma (CCPRCC) is a low-grade renal neoplasm with morphological characteristics mimicking both clear cell renal cell carcinoma (CCRCC) and papillary renal cell carcinoma (PRCC). However, despite some overlapping features, their morphological, immunohistochemical, and molecular profiles are distinct. To better understand the biology of this tumor, we analyze the miRNA expression profiles of a set of CCPRCC by microarrays.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL16770

8 Samples

Download data: TXT