GEO DataSets

(Submitter supplied) To better understand the relationship between peripheral blood- and brain-based epigenetic activity, we conducted a pilot study on captive baboons (Papio hamadryas) to investigate correlations between miRNA expression in peripheral blood mononuclear cells (PBMCs) and 14 different cortical and subcortical brain regions, represented by two study groups comprised of 4 and 6 animals. Using next-generation sequencing, we identified 362 miRNAs expressed at ≥10 read counts in 80% or more of the brain samples analyzed. more...

Organism:

Papio hamadryas

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL15440

160 Samples

Download data: XLSX

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; Papio hamadryas

Type:

Expression profiling by array; Non-coding RNA profiling by high throughput sequencing

Platforms:

GPL15440 GPL6947

22 Samples

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(Submitter supplied) The liver is a major site for synthesis, storage and redistribution of carbohydrates, proteins and lipids. In addition, it is well-known that maternal obesity (MO) increases risk of offspring cardiovascular disease (CVD), diabetes and obesity. However, the mechanisms by which the MO intrauterine environment predisposes offspring to CVD and metabolic dysregulation are unknown. The goal of this study was to assess the impact of MO on primate fetal liver and identify underlying molecular mechanisms by which MO increases disease risk. more...

Organism:

Papio hamadryas

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL15440

11 Samples

Download data: FA, XLSX

(Submitter supplied) Dysregulation of microRNAs (miRNAs) expression has been implicated in molecular genetics events leading to the progression and development of atherosclerosis. We hypothesized that miRNA expression profiles differ between baboons with low and high serum low-density lipoprotein cholesterol (LDL-C) concentrations in response to diet, and that a subset of these miRNAs regulate genes relevant to dyslipidemia and risk of atherosclerosis.

Organism:

Papio hamadryas

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL15440

12 Samples

Download data: FASTA