GEO DataSets

(Submitter supplied) Induced pluripotent stem cells (iPSCs) are regarded as a central tool to understand human biology in health and disease. Similarly, iPSCs from closely related species should be a central tool to understand human evolution and to identify conserved and variable patterns of iPSC disease models. Here, we have generated human, gorilla, bonobo and cynomolgus monkey iPSCs. We show that these cells are well comparable in their differentiation potential and generally similar to human, cynomolgus and rhesus monkey embryonic stem cells (ESCs). more...

Organism:

Macaca mulatta; Gorilla gorilla; Homo sapiens; Macaca fascicularis; Pan paniscus

Type:

Expression profiling by high throughput sequencing

5 related Platforms

23 Samples

Download data: TSV

(Submitter supplied) Only a minuscule fraction of long non-coding RNAs (lncRNAs) are well characterized. The evolutionary history of lncRNAs can provide insights into their functionality, but comparative analyses have been precluded by our ignorance of lncRNAs in non-model organisms. Here, we use RNA sequencing to identify lncRNAs in eleven tetrapod species and we present the first large-scale evolutionary study of lncRNA repertoires and expression patterns. more...

Organism:

Monodelphis domestica; Xenopus tropicalis; Macaca mulatta; Gorilla gorilla; Homo sapiens; Mus musculus; Gallus gallus; Ornithorhynchus anatinus

Type:

Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

15 related Platforms

55 Samples

Download data: BEDGRAPH, TXT

(Submitter supplied) Changes in gene expression are thought to underlie many of the phenotypic differences between species. However, large-scale analyses of gene expression evolution were until recently prevented by technological limitations. Here we report the sequencing of polyadenylated RNA from six organs across ten species that represent all major mammalian lineages (placentals, marsupials and monotremes) and birds (the evolutionary outgroup), with the goal of understanding the dynamics of mammalian transcriptome evolution. more...

Organism:

Monodelphis domestica; Pan troglodytes; Pongo pygmaeus; Gallus gallus; Ornithorhynchus anatinus; Macaca mulatta; Pan paniscus; Gorilla gorilla; Homo sapiens; Mus musculus

Type:

Expression profiling by high throughput sequencing

10 related Platforms

131 Samples

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