GPL13112[RGSE] - GEO DataSets

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Select item 2002174471.

Spermidine promotes meiotic maturation of porcine oocytes

(Submitter supplied) Spermidine is involved in a variety of biological processes, including DNA metabolism, autophagy and aging. Previous studies have shown that spermidine can increase the percentage of mouse oocytes developing into blastocysts after in vitro fertilization. However, none of the past studies elucidated the effects of spermidine supplementation on porcine oocyte maturation. Here, we choose appropriate dose of spermidine to be added to the maturation medium during in vitro maturation (IVM) to verify whether spermidine can actively promote the maturation of porcine oocytes. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
2 Samples

Download data: XLSX

Series

Accession:: GSE217447

ID:: 200217447

Select item 2002062522.

Expression data from mouse proximal tubules of the kidneys of adult female control mice and proximal-tubule specific IGF-1R KO mice, that were ovariectomized at postnatal day 21

(Submitter supplied) We used RNA-Seq analysis to detail the global programme of gene expression underlying IGF-1R knockout from proximal tubules.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
6 Samples

Download data: XLSX

Series

Accession:: GSE206252

ID:: 200206252

Select item 2001832613.

MRAP mediated adipocyte differentiation by thymic mesenchymal stromal cells contributes to thymic involution

(Submitter supplied) Adipocyte deposition is believed to be a primary characteristic of age-related thymic involution, but the underlying cellular and molecular mechanisms remain unknown. We show here that thymic mesenchymal stromal cells (tMSCs) have a higher tendency to differentiate into adipocytes and melanocortin-2 receptor accessory protein (MRAP) is a potential driver of tMSCs adipogenesis. Furthermore, we discover that thymosin-α1 promotes MRAP expression in tMSCs through FoxO1 signaling pathway. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
6 Samples

Download data: TXT

Series

Accession:: GSE183261

ID:: 200183261

SRA Run Selector

Select item 2002546784.

Circadian transcriptome analysis in mouse cultured cortical astrocytes

(Submitter supplied) To understand how the circadian clock regulates astrocyte physiology, we conducted a circadian transcriptome analysis in cultured mouse cortical astrocytes

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
24 Samples

Download data: TXT

Series

Accession:: GSE254678

ID:: 200254678

Select item 2002698445.

Dissecting AP-1 complexity in hepatic health and disease using Genetically Modified Mice

(Submitter supplied) Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death with limited, while treatment options. Thus, a better understanding of the molecular pathways involved in HCC development has become a priority to guide future therapies. While previous studies implicated the AP-1 (Fos/Jun) transcription factor family members c-Fos and c-Jun in HCC formation, the contribution of Fos-related antigens 1 and 2 (Fra-1/2) is unknown. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
12 Samples

Download data: TSV

Series

Accession:: GSE269844

ID:: 200269844

Select item 2002818446.

Copper chelation redirects neutrophil function to enhance anti-GD2 antibody therapy in neuroblastoma [GeoMx]

(Submitter supplied) Anti-disialoganglioside (GD2) antibody therapy has provided clinical benefit to patients with neuroblastoma however efficacy is likely impaired by the immunosuppressive tumor microenvironment. We have previously defined a link between intratumoral copper levels and immune evasion. Here, we report that adjuvant copper chelation potentiates anti-GD2 antibody therapy to confer durable tumor control in immunocompetent models of neuroblastoma. more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL13112
100 Samples

Download data: DCC, PKC

Series

Accession:: GSE281844

ID:: 200281844

Select item 2002803527.

p48Cre;LSL-KrasG12D Mouse Acinar and PanIN LCM RNA-Seq

(Submitter supplied) The goal of this study is to identify changes in gene expression between acinar and low-grade PanIN lesions in p48Cre;LSL-KrasG12D mice.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
2 Samples

Download data: CSV

Series

Accession:: GSE280352

ID:: 200280352

Select item 2002702818.

Cancer-cell intrinsic electrical activity drives small-cell lung cancer progression

(Submitter supplied) Elevated or ectopic expression of neuronal receptors and ion channels promotes tumor progression in many cancer types; neuroendocrine (NE) transformation of various adenocarcinomas has also been associated with increased aggressiveness. Whether the defining neuronal feature, namely electrical excitability, exists in cancer cells and whether this impacts cancer progression remains mostly unexplored. Small cell lung cancer (SCLC) is an archetypical example of highly aggressive NE cancers and is comprised of two major distinct subtypes of cancer cells: NE cells and non-NE cells. Here, we show that the NE cells are excitable, like neurons, while non-NE cells cannot fire action potentials, like astrocytes and other non-excitable cells. Action potential firing in NE cells directly promotes SCLC malignancy; however, the high ATP demand of electrical activity also leads to an unusual dependency on oxidative phosphorylation (OXPHOS) in NE cells. This finding contrasts with most cancer cells reported in the literature, which are non-excitable and heavily rely on aerobic glycolysis. Additionally, we find that non-NE cells metabolically support NE cells to supply their high ATP demand, promoting their excitability and malignancy, a process akin to the astrocyte-neuron metabolite shuttle. Lastly, we observe drastic changes in the innervation landscape during SCLC progression, which coincide with increased intratumoral heterogeneity (ITH) and elevated neuronal protein expression in SCLC cells, suggesting an induction of a tumor autonomous vicious cycle driven by cancer cell-intrinsic electrical activity, which confers long-term tumorigenic capability and metastatic potential.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
8 Samples

Download data: XLSX

Series

Accession:: GSE270281

ID:: 200270281

Select item 2002812429.

Decoupling the Biochemical and Mechanical Effects of Muscle Exercise on Motor Neurons with 2.5D Actuating Matrices

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL13112 GPL21103
38 Samples

Download data

Series

Accession:: GSE281242

ID:: 200281242

Select item 20024016010.

Next Generation Sequencing Facilitates Quantitative Analysis of wild type and Rbm25-deficient Bone Marrow Derived macrophages

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL24247 GPL13112
12 Samples

Download data: BW, NARROWPEAK

Series

Accession:: GSE240160

ID:: 200240160

PubMed

Select item 20024015811.

H3K9ac and H3K27ac Cut&Tag profiling of wild type and Rbm25-deficient Bone Marrow Derived macrophage

(Submitter supplied) Purpose: To transcriptome widely reveal histone acetylation modification H3K9ac and H3K27ac regulation by Rbm25, we performed Cleavage Under Targets and Tagmentation (CUT&Tag) analysis of wild-type (WT) and Rbm25-deficiency BMDMs. Methods: Mouse BMDMs were generated from bone marrow cells in RPMI-1640 medium with recombinant mouse M-CSF (20ng/ml). BMDMs were stained to confirm the surface expression of CD11b and F4/80. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
4 Samples

Download data: NARROWPEAK

Series

Accession:: GSE240158

ID:: 200240158

PubMed

Select item 20026725712.

Conserved role for spliceosomal component PRPF40A in microexon splicing

(Submitter supplied) Microexons (exons ≤30 nts) are important features of neuronal transcriptomes, but pose mechanistic challenges to the splicing machinery. We previously showed that PRP-40, a component of the U1 spliceosome, is globally required for microexon splicing in C. elegans. Here we show that the homologous PRPF40A is also globally required for microexon splicing in mouse neuroblastoma cells. We find that PRPF40A co-regulates microexons along with SRRM4, a neuron-specific regulator of microexon splicing. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
12 Samples

Download data: XLSX

Series

Accession:: GSE267257

ID:: 200267257

PubMed

Select item 20025481513.

A gene network of uterine luminal epithelium organizes mouse blastocyst implantation

(Submitter supplied) RNA-seq analyses using embryos and uterine luminal layers collected from female mice on day 3 am, day 4 am, day 4 pm and day 5 am of pregnancy.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
5 Samples

Download data: TXT

Series

Accession:: GSE254815

ID:: 200254815

Select item 20025337114.

Spatiotemporal functions of leukemia inhibitory factor in embryo attachment and implantation chamber formation

(Submitter supplied) RNA-seq analyses using embryos and uterine luminal layers collected from Lif-floxed, Lif uterine epithelial-specific KO (eKO), and recombinant Lif (rLif)-treated Lif eKO females on 8pm of day 4 of pregnancy.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
6 Samples

Download data: TXT

Series

Accession:: GSE253371

ID:: 200253371

Select item 20028052515.

The effect of lnc-ORA knockout on muscle fiber type transformation in mouse leg muscle.

(Submitter supplied) Skeletal muscle fiber type conversion is usually regulated by coding and non-coding RNA, which is closely related to obesity, Duchenne muscular dystrophy and sarcopenia. Furthermore, lnc-ORA KO mice were first constructed, and the results showed that lnc-ORA deficiency significantly increased exercise endurance, oxidative myofibers and mitochondrial function. Meanwhile, combining transcriptomic and proteomic data showed that lnc-ORA deficiency improved the biological processes and pathways related to the transformation of skeletal muscle fiber types. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
6 Samples

Download data: TXT

Series

Accession:: GSE280525

ID:: 200280525

Select item 20007624916.

Genome-wide mapping of Notch2 target sites in the embryonic kidney.

(Submitter supplied) During kidney development, Notch signaling plays multiple roles including promoting differentiation of nephron progenitors that give rise to all of the epithelial cells found in the nephron. Little is known about what genes Notch signaling regulates and how Notch signaling interacts with other transcription factors. To address this, we carried out genome-wide mapping of Notch2, a major Notch receptor required for differentiation of nephron progenitors, in the embryonic kidney.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
3 Samples

Download data: BED, TDF

Series

Accession:: GSE76249

ID:: 200076249

SRA Run Selector

Select item 20027906017.

ChIP-seq Profiling of RXRα in Proliferating C2C12 Myoblasts

(Submitter supplied) In this dataset, we present ChIP-seq profiling of RXRα in proliferating C2C12 myoblasts, which serves as an extension of Series GSE94558. The overall data provides genome-wide occupancy of RXRα in normal myoblast proliferation.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
1 Sample

Download data: BEDGRAPH

Series

Accession:: GSE279060

ID:: 200279060

Select item 20024406618.

Argonaute3-SF3B3 complex controls pre-mRNA splicing to restrain Type-2 immunity [RNA-seq: dissected tissues]

(Submitter supplied) Argonaute (AGO) proteins execute Micro-RNA (miRNA) mediated gene silencing. However it is currently debated whether all 4 mammalian AGO proteins (AGO1, AGO2, AGO3 and AGO4) are required for miRNA activity. To address this, we generated a mouse with deleted Ago1, Ago3 and Ago4 genes (Ago134), and found that these Argonaute proteins are completely redundant for miRNA biogenesis, miRNA homeostasis or miRNA function, a role that is carried out exclusively by AGO2. more...