GEO DataSets

(Submitter supplied) Levodopa-induced dyskinesia (LID) is a common consequence of prolonged pharmacotherapy for Parkinson's disease (PD). While LID becomes more common with long term exposure to levodopa, its development can be quite variable. We leveraged the variable expression of LID in a rat model to interrogate differential gene expression in the substantia nigra and striatum of animals that develop LID and those that do not. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL10741

24 Samples

Download data: CEL

(Submitter supplied) Cardiac cachexia is a common complication of heart failure in severe cases and is associated with a poor prognosis. Several skeletal muscle abnormalities have been described in patients and animals with cardiac cachexia; these include atrophy, fibrosis, altered myosin heavy chain composition, and decreased oxidative capacity. It is also well established that gene expression patterns are substantially altered in cardiac cachexia, but the reasons for such differences are not clear.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL10741

6 Samples

Download data: CEL

(Submitter supplied) Defects in nephrogenesis can have detrimental effects on cardiovascular and renal health in adult life. This is confirmed by observations in the Munich Wistar Frömter (MWF) rat that exhibits a congenital nephron deficit and renal failure with age. We performed genome-wide transcriptome analysis in embryonic kidneys to identify candidate genes for the reduced nephron number in MWF. We compared MWF E15.5 with stage-matched spontaneously hypertensive rats (SHR) at E16. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL6247 GPL10741

16 Samples

Download data: CEL

(Submitter supplied) In this study we showed that rat XEN cells grown in the presence of a GSK3 inhibitor exhibited enhanced formation of cell contacts and decreased motility. In contrast, treatment with forskolin induced the PE formation and epithelial-mesenchymal transition (EMT) in rat XEN cells. Using microarray and real-time PCR assays, we found that VE versus PE formation of rat XEN cells was correlated with change in expression levels of VE or PE marker genes. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL10741

12 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL10741

18 Samples

Download data: CEL

(Submitter supplied) RAS mutations are highly relevant for progression and therapy response of human tumours, but the genetic network that ultimately executes the oncogenic effects is poorly understood. Here we used a reverse-engineering approach in an ovarian cancer model to reconstruct KRAS oncogene-dependent cytoplasmic and transcriptional networks from perturbation experiments based on gene silencing and pathway inhibitor treatments. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL10741

2 Samples

Download data: CEL

(Submitter supplied) RAS mutations are highly relevant for progression and therapy response of human tumours, but the genetic network that ultimately executes the oncogenic effects is poorly understood. Here we used a reverse-engineering approach in an ovarian cancer model to reconstruct KRAS oncogene-dependent cytoplasmic and transcriptional networks from perturbation experiments based on gene silencing and pathway inhibitor treatments. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL10741

16 Samples

Download data: CEL

(Submitter supplied) Purpose: To investigate the effect of transcorneal electrical stimulation (TES) on the retina of wildtype Brown Norway (BN) rats by gene expression profiling. Methods: TES was applied to BN adult wildtype rat retina in vivo for 1h (1ms biphasic pulses at 20Hz; current: 200 µA). RNA was isolated, processed and used for microarray-based expression profiling 4hrs after initial TES. An expression profile was generated for genes differentially expressed at 4hrs after TES vs. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL10741

8 Samples

Download data: CEL, CHP

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html #%create_date=Tue Dec 8 17:34:30 2009 PST #%chip_type=RaGene-1_0-st-v1 #%lib_set_name=RaGene-1_0-st #%lib_set_version=v1 #%genome-species=Rattus norvegicus #%genome-version=rn4 #%genome-version-ucsc=rn4 #%genome-version-ncbi=HGSC v3.4 #%genome-version-create_date=2004-11 #%netaffx-annotation-date=2009-11-16 #%netaffx-annotation-netaffx-build=30.1 Protocol: See manufacturer's web site

Organism:

Rattus norvegicus

8 Series

76 Samples

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