(txid50954[Organism:noexp]) AND gds_sra[filter] - GEO DataSets

Warning: The NCBI web site requires JavaScript to function. more...

Search results

Items: 6

Select item 2002184371.

Co-option of the transcription factor SALL1 in mole ovotestis formation [4C]

(Submitter supplied) Changes in gene expression represent an important source for phenotypical innovation. Yet, how such changes emerge and impact the evolution of traits remains elusive. Here, we explore the molecular mechanisms associated with the development of masculinizing ovotestes in female moles. By performing comparative analyses of epigenetic and transcriptional data in mole and mouse, we identified SALL1 as a co-opted gene for the formation of testicular tissue in mole ovotestes. more...

Organism:: Talpa occidentalis

Type:: Other

Platform:: GPL25619
1 Sample

Download data: TXT

Series

Accession:: GSE218437

ID:: 200218437

PubMed Full text in PMC Similar studies

Select item 2001363332.

The mole genome reveals regulatory rearrangements associated with adaptive intersexuality (Hi-C)

(Submitter supplied) Linking genomic variation to phenotypical traits remains a major challenge in evolutionary genetics. In this study, we use phylogenomic strategies to investigate a distinctive trait among mammals: the development of masculinizing ovotestes in female moles. By combining a chromosome-scale genome assembly of the Iberian mole, Talpa occidentalis, with transcriptomic, epigenetic, and chromatin interaction datasets, we identify rearrangements altering the regulatory landscape of genes with distinct gonadal expression patterns. more...