nstd217 (Zhang et al. 2022)
- Organism:
- Human
- Study Type:
- Somatic
- Submitter:
- Li-Qun Zhang
- Description:
- We report a rare interlocus recombination between HLA-A and HLA-H, which was analyzed using next generation sequencing and nanopore sequencing.In the sample, the genotypes of HLA-A, B, C, DRB1, and DQB1 were firstly determined using the methods of sequence-specific primer, sequence-specific oligonucleotide, Sanger’s sequencing, and NGS; however, HLA-A could not be phased. Nanopore sequencing was finally utilized to distinguish the sequence of the novel allele.The novel HLA-A*11:335 allele was identified as an interlocus recombination involving HLA-A*11:01:01:01/126 and HLA-H*02:07/14/18 alleles; this was mainly achieved by nanopore sequencing. See Variant Summary counts for nstd217 in dbVar Variant Summary.
- Publication(s):
- Zhang et al. 2022