Related gene-specific medical variations for Gene (Select 1719) - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 3375794	NM_002439.5(MSH3):c.178_179insTCGCAGCGC (p.Ala60delinsValAlaAlaPro)	DHFR, MSH3	Insertion (5 prime UTR variant +2 more)	not provided	GUncertain significance
Select item 3368562	NM_002439.5(MSH3):c.166_167insAGGCCGCAGCGGCCGCAG (p.Ala55_Ala56insGluAlaAlaAlaAlaAla)	DHFR, MSH3	Insertion (5 prime UTR variant +2 more)	not provided	GUncertain significance
Select item 3367896	NM_002439.5(MSH3):c.190C>T (p.Pro64Ser)	DHFR, MSH3 (P64S)	Single nucleotide variant (5 prime UTR variant +2 more)	not provided	GUncertain significance
Select item 3296312	NM_002439.5(MSH3):c.66G>T (p.Ala22=)	DHFR, MSH3	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3296306	NM_002439.5(MSH3):c.207C>G (p.Pro69=)	DHFR, MSH3	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3296294	NM_002439.5(MSH3):c.211T>C (p.Phe71Leu)	DHFR, MSH3 (F71L)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3256188	NM_000791.4(DHFR):c.-418_-392del	DHFR, MSH3	Deletion (5 prime UTR variant +2 more)	not specified	GLikely benign
Select item 3256187	NM_000791.4(DHFR):c.-204T>A	DHFR, MSH3	Single nucleotide variant (5 prime UTR variant +1 more)	not specified	GLikely benign
Select item 3239783	NM_002439.5(MSH3):c.200C>A (p.Pro67Gln)	DHFR, MSH3 (P67Q)	Single nucleotide variant (5 prime UTR variant +2 more)	Endometrial carcinoma	GUncertain significance
Select item 3239776	NM_002439.5(MSH3):c.166_167insGGGCCGCAG (p.Ala55_Ala56insGlyAlaAla)	DHFR, MSH3	Insertion (inframe_insertion +2 more)	Endometrial carcinoma	GLikely benign
Select item 3222316	NM_002439.5(MSH3):c.98G>T (p.Ser33Ile)	DHFR, MSH3 (S33I)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3222312	NM_002439.5(MSH3):c.81C>G (p.Phe27Leu)	DHFR, MSH3 (F27L)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3222302	NM_002439.5(MSH3):c.55G>A (p.Ala19Thr)	DHFR, MSH3 (A19T)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3222299	NM_002439.5(MSH3):c.40T>G (p.Ser14Ala)	DHFR, MSH3 (S14A)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3222263	NM_002439.5(MSH3):c.237+4G>T	DHFR, MSH3	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3222262	NM_002439.5(MSH3):c.235_237delinsGTG (p.Ile79Val)	DHFR, MSH3 (I79V)	Indel (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome	GBenign
Select item 3222252	NM_002439.5(MSH3):c.201A>G (p.Pro67=)	DHFR, MSH3	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3222236	NM_002439.5(MSH3):c.13A>C (p.Lys5Gln)	DHFR, MSH3 (K5Q)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3021557	NM_002439.5(MSH3):c.87G>C (p.Gln29His)	DHFR, MSH3 (Q29H)	Single nucleotide variant (5 prime UTR variant +2 more)	not provided	GUncertain significance
Select item 3009116	NM_002439.5(MSH3):c.125G>T (p.Gly42Val)	DHFR, MSH3 (G42V)	Single nucleotide variant (5 prime UTR variant +2 more)	not provided	GUncertain significance
Select item 3001787	NM_002439.5(MSH3):c.237+19T>G	DHFR, MSH3	Single nucleotide variant (5 prime UTR variant +2 more)	not provided	GLikely benign
Select item 2993396	NM_002439.5(MSH3):c.151_189dup (p.Pro63_Pro64insAlaAlaAlaAlaAlaAlaAlaAlaAlaAlaAlaAlaPro)	DHFR, MSH3	Duplication (5 prime UTR variant +2 more)	not provided	GUncertain significance
Select item 2991562	NM_002439.5(MSH3):c.99C>T (p.Ser33=)	DHFR, MSH3	Single nucleotide variant (5 prime UTR variant +2 more)	not provided +1 more	GLikely benign
Select item 2986392	NM_002439.5(MSH3):c.114del (p.Ser39fs)	DHFR, MSH3 (S39fs)	Deletion (5 prime UTR variant +2 more)	not provided	GPathogenic
Select item 2975560	NM_002439.5(MSH3):c.78A>C (p.Arg26=)	DHFR, MSH3	Single nucleotide variant (5 prime UTR variant +2 more)	not provided	GLikely benign
Select item 2968110	NM_002439.5(MSH3):c.34G>C (p.Ala12Pro)	DHFR, MSH3 (A12P)	Single nucleotide variant (5 prime UTR variant +2 more)	not provided	GUncertain significance
Select item 2883236	NM_002439.5(MSH3):c.237+5G>C	DHFR, MSH3	Single nucleotide variant (5 prime UTR variant +2 more)	not provided	GUncertain significance
Select item 2882147	NM_002439.5(MSH3):c.228G>A (p.Pro76=)	DHFR, MSH3	Single nucleotide variant (5 prime UTR variant +2 more)	not provided	GLikely benign
Select item 2877686	NM_002439.5(MSH3):c.133G>T (p.Asp45Tyr)	DHFR, MSH3 (D45Y)	Single nucleotide variant (5 prime UTR variant +2 more)	not provided	GUncertain significance
Select item 2865556	NM_002439.5(MSH3):c.13A>G (p.Lys5Glu)	DHFR, MSH3 (K5E)	Single nucleotide variant (5 prime UTR variant +2 more)	not provided	GUncertain significance
Select item 2846573	NM_002439.5(MSH3):c.82T>G (p.Phe28Val)	DHFR, MSH3 (F28V)	Single nucleotide variant (5 prime UTR variant +2 more)	not provided	GUncertain significance
Select item 2845317	NM_002439.5(MSH3):c.129A>C (p.Ala43=)	DHFR, MSH3	Single nucleotide variant (5 prime UTR variant +2 more)	not provided	GLikely benign
Select item 2834990	NM_002439.5(MSH3):c.36T>G (p.Ala12=)	DHFR, MSH3	Single nucleotide variant (5 prime UTR variant +2 more)	not provided	GLikely benign
Select item 2816593	NM_002439.5(MSH3):c.65C>G (p.Ala22Gly)	DHFR, MSH3 (A22G)	Single nucleotide variant (5 prime UTR variant +2 more)	not provided	GUncertain significance
Select item 2810537	NM_002439.5(MSH3):c.110C>T (p.Thr37Ile)	DHFR, MSH3 (T37I)	Single nucleotide variant (5 prime UTR variant +2 more)	not provided	GUncertain significance
Select item 2808231	NM_002439.5(MSH3):c.86del (p.Gln29fs)	DHFR, MSH3 (Q29fs)	Deletion (5 prime UTR variant +2 more)	not provided	GPathogenic
Select item 2807709	NM_002439.5(MSH3):c.153_190del (p.Ala52fs)	DHFR, MSH3 (A52fs)	Deletion (5 prime UTR variant +2 more)	not provided	GPathogenic
Select item 2791324	NM_002439.5(MSH3):c.228G>C (p.Pro76=)	DHFR, MSH3	Single nucleotide variant (5 prime UTR variant +2 more)	not provided	GLikely benign
Select item 2760008	NM_002439.5(MSH3):c.54T>G (p.Pro18=)	DHFR, MSH3	Single nucleotide variant (5 prime UTR variant +2 more)	not provided	GLikely benign
Select item 2757581	NM_002439.5(MSH3):c.123A>G (p.Thr41=)	DHFR, MSH3	Single nucleotide variant (5 prime UTR variant +2 more)	not provided	GLikely benign
Select item 2754317	NM_002439.5(MSH3):c.77G>T (p.Arg26Leu)	DHFR, MSH3 (R26L)	Single nucleotide variant (5 prime UTR variant +2 more)	not provided	GUncertain significance
Select item 2742817	NM_002439.5(MSH3):c.119C>G (p.Ser40Cys)	DHFR, MSH3 (S40C)	Single nucleotide variant (5 prime UTR variant +2 more)	not provided	GUncertain significance
Select item 2710606	NM_002439.5(MSH3):c.62A>T (p.Gln21Leu)	DHFR, MSH3 (Q21L)	Single nucleotide variant (5 prime UTR variant +2 more)	not provided	GUncertain significance
Select item 2701275	NM_002439.5(MSH3):c.146C>A (p.Pro49His)	DHFR, MSH3 (P49H)	Single nucleotide variant (5 prime UTR variant +2 more)	not provided	GUncertain significance
Select item 2691909	NM_000791.4(DHFR):c.-424_-420CGCTGGGGG[2]CGCTGGGGCCGCTG[1]	DHFR, MSH3	Insertion (5 prime UTR variant +2 more)	not specified	GLikely benign
Select item 2682015	NM_002439.5(MSH3):c.44G>A (p.Ser15Asn)	DHFR, MSH3 (S15N)	Single nucleotide variant (5 prime UTR variant +2 more)	not provided	GUncertain significance
Select item 2676781	NM_002439.5(MSH3):c.169_196del (p.Ala57fs)	DHFR, MSH3 (A57fs)	Deletion (5 prime UTR variant +2 more)	Endometrial carcinoma	GLikely pathogenic
Select item 2676780	NM_002439.5(MSH3):c.161del (p.Ala54fs)	DHFR, MSH3 (A54fs)	Deletion (5 prime UTR variant +2 more)	Endometrial carcinoma	GLikely pathogenic
Select item 2676774	NM_002439.5(MSH3):c.15del (p.Lys5fs)	DHFR, MSH3 (K5fs)	Deletion (5 prime UTR variant +2 more)	Endometrial carcinoma	GLikely pathogenic
Select item 2676773	NM_002439.5(MSH3):c.96delinsCT (p.Gly32_Ser33insTer)	DHFR, MSH3	Indel (5 prime UTR variant +2 more)	Endometrial carcinoma	GLikely pathogenic
Select item 2676772	NM_002439.5(MSH3):c.202G>A (p.Ala68Thr)	DHFR, MSH3 (A68T)	Single nucleotide variant (5 prime UTR variant +2 more)	Endometrial carcinoma	GUncertain significance
Select item 2676764	NM_002439.5(MSH3):c.53C>T (p.Pro18Leu)	DHFR, MSH3 (P18L)	Single nucleotide variant (5 prime UTR variant +2 more)	Endometrial carcinoma	GUncertain significance
Select item 2676757	NM_002439.5(MSH3):c.152C>G (p.Ala51Gly)	DHFR, MSH3 (A51G)	Single nucleotide variant (5 prime UTR variant +2 more)	Endometrial carcinoma +1 more	GUncertain significance
Select item 2676748	NM_002439.5(MSH3):c.200dup (p.Ala68fs)	DHFR, MSH3 (A68fs)	Duplication (5 prime UTR variant +2 more)	Endometrial carcinoma	GLikely pathogenic
Select item 2676745	NM_002439.5(MSH3):c.4T>A (p.Ser2Thr)	DHFR, MSH3 (S2T)	Single nucleotide variant (5 prime UTR variant +2 more)	Endometrial carcinoma	GUncertain significance
Select item 2676741	NM_002439.5(MSH3):c.196C>A (p.Pro66Thr)	DHFR, MSH3 (P66T)	Single nucleotide variant (5 prime UTR variant +2 more)	Endometrial carcinoma	GUncertain significance
Select item 2676736	NM_002439.5(MSH3):c.23C>T (p.Ser8Leu)	DHFR, MSH3 (S8L)	Single nucleotide variant (5 prime UTR variant +2 more)	not provided +1 more	GUncertain significance
Select item 2673975	NM_002439.5(MSH3):c.-34_-10dup	DHFR, MSH3	Duplication (5 prime UTR variant +1 more)	Familial adenomatous polyposis 4	GBenign
Select item 2673932	NM_002439.5(MSH3):c.-30_-18dup	DHFR, MSH3	Duplication (5 prime UTR variant +1 more)	Familial adenomatous polyposis 4	GBenign
Select item 2673571	NM_002439.5(MSH3):c.61C>T (p.Gln21Ter)	DHFR, MSH3 (Q21*)	Single nucleotide variant (5 prime UTR variant +2 more)	Familial adenomatous polyposis 4	GPathogenic
Select item 2673556	NM_002439.5(MSH3):c.85del (p.Gln29fs)	DHFR, MSH3 (Q29fs)	Deletion (5 prime UTR variant +2 more)	Familial adenomatous polyposis 4	GPathogenic
Select item 2673531	NM_002439.5(MSH3):c.90dup (p.Thr31fs)	DHFR, MSH3 (T31fs)	Duplication (5 prime UTR variant +2 more)	Familial adenomatous polyposis 4	GPathogenic
Select item 2673506	NM_002439.5(MSH3):c.36del (p.Ala13fs)	DHFR, MSH3 (A13fs)	Deletion (5 prime UTR variant +2 more)	Familial adenomatous polyposis 4	GPathogenic
Select item 2673497	NM_002439.5(MSH3):c.85C>T (p.Gln29Ter)	DHFR, MSH3 (Q29*)	Single nucleotide variant (5 prime UTR variant +2 more)	Familial adenomatous polyposis 4	GPathogenic
Select item 2655571	NM_002439.5(MSH3):c.178CCCCCAGCG[3] (p.Ala59_Ala60insProProAlaProProAlaProProAla)	DHFR, MSH3	Microsatellite (5 prime UTR variant +2 more)	not provided	GUncertain significance
Select item 2635185	NM_002439.5(MSH3):c.221A>G (p.Gln74Arg)	DHFR, MSH3 (Q74R)	Single nucleotide variant (5 prime UTR variant +2 more)	MSH3-related disorder	GUncertain significance
Select item 2586077	NM_002439.5(MSH3):c.106T>C (p.Ser36Pro)	DHFR, MSH3 (S36P)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 2586075	NM_002439.5(MSH3):c.-1C>T	DHFR, MSH3	Single nucleotide variant (5 prime UTR variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 2586065	NM_002439.5(MSH3):c.154G>A (p.Ala52Thr)	DHFR, MSH3 (A52T)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 2586057	NM_002439.5(MSH3):c.88T>A (p.Ser30Thr)	DHFR, MSH3 (S30T)	Single nucleotide variant (5 prime UTR variant +2 more)	not provided +1 more	GUncertain significance
Select item 2575341	NM_000791.4(DHFR):c.-420_-419insGGGGCGCTGCGGCCGCTG	DHFR, MSH3	Insertion (5 prime UTR variant +2 more)	not specified	GLikely benign
Select item 2575340	NM_000791.4(DHFR):c.-420GGGGGCGCT[2]G[5]CG[1]	DHFR, MSH3	Microsatellite (5 prime UTR variant +2 more)	not specified	GLikely benign
Select item 2575339	NM_000791.4(DHFR):c.-425GCGCTGCGG[3]	DHFR, MSH3	Microsatellite (5 prime UTR variant +2 more)	not specified	GLikely benign
Select item 2575338	NM_000791.4(DHFR):c.-415_-400del	DHFR, MSH3 (A55fs)	Deletion (5 prime UTR variant +2 more)	not specified	GLikely benign
Select item 2575337	NM_000791.4(DHFR):c.-214C>T	DHFR, MSH3	Single nucleotide variant (5 prime UTR variant +1 more)	not specified	GLikely benign
Select item 2575124	NM_000791.4(DHFR):c.-444G>A	DHFR, MSH3 (P69L)	Single nucleotide variant (5 prime UTR variant +2 more)	not specified	GUncertain significance
Select item 2565687	NM_002439.5(MSH3):c.42C>T (p.Ser14=)	DHFR, MSH3	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 2565673	NM_002439.5(MSH3):c.35C>G (p.Ala12Gly)	DHFR, MSH3 (A12G)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 2565660	NM_002439.5(MSH3):c.213C>G (p.Phe71Leu)	DHFR, MSH3 (F71L)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 2565651	NM_002439.5(MSH3):c.46T>A (p.Ser16Thr)	DHFR, MSH3 (S16T)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 2482282	NM_002439.5(MSH3):c.203C>G (p.Ala68Gly)	DHFR, MSH3 (A68G)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 2451079	NM_002439.5(MSH3):c.158C>A (p.Ala53Glu)	DHFR, MSH3 (A53E)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 2451077	NM_002439.5(MSH3):c.147_154dup (p.Ala52fs)	DHFR, MSH3 (A52fs)	Duplication (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 2451067	NM_002439.5(MSH3):c.205_224del (p.Pro69fs)	DHFR, MSH3 (P69fs)	Deletion (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 2451066	NM_002439.5(MSH3):c.219_230dup (p.Pro77_His78insGlnLeuProPro)	DHFR, MSH3	Duplication (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 2451053	NM_002439.5(MSH3):c.105A>G (p.Lys35=)	DHFR, MSH3	Single nucleotide variant (5 prime UTR variant +2 more)	not provided +1 more	GLikely benign
Select item 2451037	NM_002439.5(MSH3):c.-5C>G	DHFR, MSH3	Single nucleotide variant (5 prime UTR variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 2451036	NM_002439.5(MSH3):c.182C>T (p.Ala61Val)	DHFR, MSH3 (A61V)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 2446933	NM_002439.5(MSH3):c.155C>T (p.Ala52Val)	DHFR, MSH3 (A52V)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 2443181	NM_002439.5(MSH3):c.161_162insCGCAGCGGC (p.Ala62_Pro63insAlaAlaAla)	DHFR, MSH3	Insertion (5 prime UTR variant +2 more)	not specified	GUncertain significance
Select item 2337509	NM_002439.5(MSH3):c.236T>A (p.Ile79Lys)	DHFR, MSH3 (I79K)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 2187597	NM_002439.5(MSH3):c.158C>T (p.Ala53Val)	DHFR, MSH3 (A53V)	Single nucleotide variant (5 prime UTR variant +2 more)	not provided +1 more	GUncertain significance
Select item 2185084	NM_002439.5(MSH3):c.116C>G (p.Ser39Cys)	DHFR, MSH3 (S39C)	Single nucleotide variant (5 prime UTR variant +2 more)	not provided	GUncertain significance
Select item 2179069	NM_002439.5(MSH3):c.25G>A (p.Gly9Ser)	DHFR, MSH3 (G9S)	Single nucleotide variant (5 prime UTR variant +2 more)	not provided	GUncertain significance
Select item 2166926	NM_002439.5(MSH3):c.218C>T (p.Pro73Leu)	DHFR, MSH3 (P73L)	Single nucleotide variant (5 prime UTR variant +2 more)	not provided	GUncertain significance
Select item 2165168	NM_002439.5(MSH3):c.237+15G>A	DHFR, MSH3	Single nucleotide variant (5 prime UTR variant +2 more)	not provided	GLikely benign
Select item 2162775	NM_002439.5(MSH3):c.47C>G (p.Ser16Ter)	DHFR, MSH3 (S16*)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome +2 more	GPathogenic/Likely pathogenic
Select item 2123718	NM_002439.5(MSH3):c.144C>A (p.Asp48Glu)	DHFR, MSH3 (D48E)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 2107980	NM_002439.5(MSH3):c.231G>A (p.Pro77=)	DHFR, MSH3	Single nucleotide variant (5 prime UTR variant +2 more)	not provided	GLikely benign
Select item 2105672	NM_002439.5(MSH3):c.237+13_237+14insCTTCAGTGAGTTTCTTAATCTTGAGTTCTAATTTGATTGTACTGTGTTCTGA	DHFR, MSH3	Insertion (5 prime UTR variant +2 more)	not provided	GUncertain significance

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