ClinVar for Gene (Select 6390) - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 3379459	NM_003000.3(SDHB):c.246A>T (p.Glu82Asp)	SDHB (E82D)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 3378367	NM_003000.3(SDHB):c.643-11T>A	SDHB	Single nucleotide variant (intron variant)	not provided	GUncertain significance
Select item 3363740	NM_003000.3(SDHB):c.542A>G (p.Asp181Gly)	SDHB (D163G +1 more)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 3346697	NM_003000.3(SDHB):c.460_469del (p.Ile153_Glu154insTer)	SDHB	Deletion (nonsense +1 more)	SDHB-related disorder	GPathogenic
Select item 3346563	NM_003000.3(SDHB):c.667A>G (p.Arg223Gly)	SDHB (R205G +1 more)	Single nucleotide variant (missense variant)	SDHB-related disorder	GUncertain significance
Select item 3337564	NM_003000.3(SDHB):c.841dup (p.Ter281LeuextTer?)	SDHB	Duplication (frameshift variant +1 more)	not provided	GUncertain significance
Select item 3316903	NM_003000.3(SDHB):c.104C>T (p.Thr35Ile)	SDHB (T35I)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3316902	NM_003000.3(SDHB):c.657G>A (p.Met219Ile)	SDHB (M201I +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3316901	NM_003000.3(SDHB):c.52C>G (p.Leu18Val)	LOC129929542, SDHB (L18V)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3316900	NM_003000.3(SDHB):c.28A>T (p.Arg10Trp)	SDHB (R10W)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3316899	NM_003000.3(SDHB):c.289A>C (p.Ile97Leu)	SDHB (I97L)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3316898	NM_003000.3(SDHB):c.237T>A (p.Ile79=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3316896	NM_003000.3(SDHB):c.606C>A (p.Asn202Lys)	SDHB (N184K +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3316895	NM_003000.3(SDHB):c.523del (p.Glu175fs)	SDHB (E175fs +1 more)	Deletion (frameshift variant)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3316894	NM_003000.3(SDHB):c.465T>G (p.Pro155=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3316893	NM_003000.3(SDHB):c.268C>A (p.Arg90=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3316892	NM_003000.3(SDHB):c.444_445delinsTCTATGG (p.Gln149fs)	SDHB (Q149fs +1 more)	Indel (frameshift variant)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3316891	NM_003000.3(SDHB):c.671A>T (p.Asp224Val)	SDHB (D224V +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3316890	NM_003000.3(SDHB):c.765+1721_765+1726delinsTTTT	SDHB	Indel (intron variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3316889	NM_003000.3(SDHB):c.286+2T>C	SDHB	Single nucleotide variant (splice donor variant)	Hereditary cancer-predisposing syndrome	GLikely pathogenic
Select item 3316888	NM_003000.3(SDHB):c.533A>G (p.Glu178Gly)	SDHB (E160G +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3316887	NM_003000.3(SDHB):c.256_258del (p.Thr86del)	SDHB (T86del)	Deletion (inframe_deletion +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3316886	NM_003000.3(SDHB):c.650G>C (p.Arg217Pro)	SDHB (R199P +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GLikely pathogenic
Select item 3316885	NM_003000.3(SDHB):c.110C>A (p.Pro37His)	SDHB (P37H)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3316884	NM_003000.3(SDHB):c.17C>T (p.Ala6Val)	SDHB (A6V)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3316883	NM_003000.3(SDHB):c.56G>A (p.Gly19Asp)	LOC129929542, SDHB (G19D)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3316880	NM_003000.3(SDHB):c.203G>C (p.Cys68Ser)	SDHB (C68S)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3257573	GRCh37/hg19 1p36.13(chr1:17380443-17380514)x1	SDHB	Copy number loss	not provided	GPathogenic
Select item 3256465	NM_003000.3(SDHB):c.200+44A>C	SDHB	Single nucleotide variant (intron variant)	not specified	GLikely benign
Select item 3256437	NM_003000.3(SDHB):c.287-40G>T	SDHB	Single nucleotide variant (intron variant)	not specified	GLikely benign
Select item 3256401	NM_003000.3(SDHB):c.416T>C (p.Leu139Pro)	SDHB (L139P)	Single nucleotide variant (missense variant +1 more)	not provided	GLikely pathogenic
Select item 3256375	NM_003000.3(SDHB):c.*13T>C	SDHB	Single nucleotide variant (3 prime UTR variant)	not specified	GLikely benign
Select item 3254296	NM_003000.3(SDHB):c.375_376delinsGT (p.Lys126Ter)	SDHB (K126*)	Indel (nonsense +1 more)	Paragangliomas 4	GPathogenic
Select item 3247661	NC_000001.10:g.(?_17356590)_(17359633_?)del	SDHB	Deletion	Gastrointestinal stromal tumor +2 more	GLikely pathogenic
Select item 3247660	NC_000001.10:g.(?_17345376)_(17359660_?)dup	SDHB	Duplication	Gastrointestinal stromal tumor +2 more	GUncertain significance
Select item 3247659	NC_000001.10:g.(?_17354234)_(17371393_?)dup	SDHB	Duplication	Gastrointestinal stromal tumor +2 more	GUncertain significance
Select item 3247658	NC_000001.10:g.(?_17371236)_(17380514_?)dup	SDHB	Duplication	Gastrointestinal stromal tumor +2 more	GUncertain significance
Select item 3247656	NC_000001.10:g.(?_17371236)_(17371403_?)dup	SDHB	Duplication	Gastrointestinal stromal tumor +2 more	GLikely pathogenic
Select item 3247655	NC_000001.10:g.(?_17380423)_(17380514_?)del	SDHB	Deletion	Gastrointestinal stromal tumor +2 more	GPathogenic
Select item 3242274	GRCh37/hg19 1p36.32-36.12(chr1:4436802-22782007)x2	AADACL3, AADACL4 +207 more	Copy number loss	not provided	GPathogenic
Select item 3233926	NC_000001.10:g.(17355232_17359554)_(17359641_17371255)del	SDHB	Deletion	Hereditary pheochromocytoma-paraganglioma	GPathogenic
Select item 3223024	NM_003000.3(SDHB):c.837A>C (p.Ser279=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3223023	NM_003000.3(SDHB):c.791C>G (p.Ala264Gly)	SDHB (A246G +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3223022	NM_003000.3(SDHB):c.78C>T (p.Ser26=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3223021	NM_003000.3(SDHB):c.757_760dup (p.Pro254fs)	SDHB (P236fs +1 more)	Duplication (frameshift variant)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3223020	NM_003000.3(SDHB):c.725G>T (p.Arg242Leu)	SDHB (R224L +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3223019	NM_003000.3(SDHB):c.714C>T (p.Phe238=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3223018	NM_003000.3(SDHB):c.70C>G (p.Gln24Glu)	LOC129929542, SDHB (Q24E)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3223017	NM_003000.3(SDHB):c.703C>G (p.Gln235Glu)	SDHB (Q217E +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3223015	NM_003000.3(SDHB):c.687dup (p.Arg230fs)	SDHB (R212fs +1 more)	Duplication (frameshift variant)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3223014	NM_003000.3(SDHB):c.660T>C (p.Ile220=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3223013	NM_003000.3(SDHB):c.651C>G (p.Arg217=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3223012	NM_003000.3(SDHB):c.472A>G (p.Lys158Glu)	SDHB (K140E +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3223011	NM_003000.3(SDHB):c.456C>T (p.Ser152=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3223010	NM_003000.3(SDHB):c.446A>C (p.Gln149Pro)	SDHB (Q131P +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3223008	NM_003000.3(SDHB):c.37T>C (p.Leu13=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3223006	NM_003000.3(SDHB):c.348G>T (p.Arg116Ser)	SDHB (R116S)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3223005	NM_003000.3(SDHB):c.222T>C (p.Asp74=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3223004	NM_003000.3(SDHB):c.167C>T (p.Pro56Leu)	SDHB (P56L)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3223003	NM_003000.3(SDHB):c.164A>C (p.Lys55Thr)	SDHB (K55T)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3223002	NM_003000.3(SDHB):c.11T>C (p.Val4Ala)	SDHB (V4A)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3158929	NM_003000.3(SDHB):c.130A>T (p.Ile44Phe)	SDHB (I44F)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3076063	NM_003000.3(SDHB):c.81del (p.Gly28fs)	SDHB (G28fs)	Deletion (frameshift variant)	Hereditary pheochromocytoma-paraganglioma	GLikely pathogenic
Select item 3075408	NM_003000.3(SDHB):c.825G>A (p.Glu275=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary pheochromocytoma-paraganglioma	GLikely benign
Select item 3075391	NM_003000.3(SDHB):c.288C>T (p.Gly96=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary pheochromocytoma-paraganglioma	GLikely benign
Select item 3075205	NM_003000.3(SDHB):c.821A>T (p.Lys274Met)	SDHB (K256M +1 more)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma +1 more	GUncertain significance
Select item 3075087	NM_003000.3(SDHB):c.818A>G (p.Tyr273Cys)	SDHB (Y255C +1 more)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma	GUncertain significance
Select item 3074941	NM_003000.3(SDHB):c.359A>T (p.Asn120Ile)	SDHB (N120I)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma	GUncertain significance
Select item 3074812	NM_003000.3(SDHB):c.262A>G (p.Thr88Ala)	SDHB (T88A)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma	GUncertain significance
Select item 3074069	NM_003000.3(SDHB):c.200+5G>A	SDHB	Single nucleotide variant (intron variant)	Hereditary pheochromocytoma-paraganglioma +1 more	GUncertain significance
Select item 3073992	NM_003000.3(SDHB):c.476A>G (p.Lys159Arg)	SDHB (K141R +1 more)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma	GUncertain significance
Select item 3072659	NM_003000.3(SDHB):c.643-6T>C	SDHB	Single nucleotide variant (intron variant)	Hereditary pheochromocytoma-paraganglioma	GLikely benign
Select item 3071935	NM_003000.3(SDHB):c.562C>T (p.Leu188Phe)	SDHB (L170F +1 more)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma +1 more	GUncertain significance
Select item 3071913	NM_003000.3(SDHB):c.404T>C (p.Val135Ala)	SDHB (V135A)	Single nucleotide variant (missense variant +1 more)	Hereditary pheochromocytoma-paraganglioma	GUncertain significance
Select item 3071895	NM_003000.3(SDHB):c.672T>A (p.Asp224Glu)	SDHB (D206E +1 more)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma	GUncertain significance
Select item 3071844	NM_003000.3(SDHB):c.-1G>A	SDHB	Single nucleotide variant (5 prime UTR variant)	Hereditary pheochromocytoma-paraganglioma +1 more	GUncertain significance
Select item 3071481	NM_003000.3(SDHB):c.266T>G (p.Phe89Cys)	SDHB (F89C)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma	GUncertain significance
Select item 3071038	NM_003000.3(SDHB):c.-9G>A	SDHB	Single nucleotide variant (5 prime UTR variant)	Hereditary pheochromocytoma-paraganglioma	GUncertain significance
Select item 3070639	NM_003000.3(SDHB):c.-13del	SDHB	Deletion (5 prime UTR variant)	Hereditary pheochromocytoma-paraganglioma	GUncertain significance
Select item 3070294	NM_003000.3(SDHB):c.62C>A (p.Ala21Asp)	LOC129929542, SDHB (A21D)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma	GUncertain significance
Select item 3069734	NM_003000.3(SDHB):c.511C>G (p.Leu171Val)	SDHB (L153V +1 more)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma	GUncertain significance
Select item 3062822	GRCh37/hg19 1p36.21-36.12(chr1:16194137-20561434)x1	ACTL8, AKR7A2 +58 more	Copy number loss	not specified	GPathogenic
Select item 3029005	NM_003000.3(SDHB):c.200+8T>C	SDHB	Single nucleotide variant (intron variant)	SDHB-related disorder	GLikely benign
Select item 2954035	NM_003000.3(SDHB):c.84_141dup (p.Asp48fs)	SDHB (D48fs)	Duplication (frameshift variant)	Gastrointestinal stromal tumor +2 more	GPathogenic
Select item 2953788	NM_003000.3(SDHB):c.272G>C (p.Arg91Thr)	SDHB (R91T)	Single nucleotide variant (missense variant)	Gastrointestinal stromal tumor +2 more	GUncertain significance
Select item 2953496	NM_003000.3(SDHB):c.690C>A (p.Arg230=)	SDHB	Single nucleotide variant (synonymous variant)	Gastrointestinal stromal tumor +3 more	GLikely benign
Select item 2952299	NM_003000.3(SDHB):c.154G>T (p.Ala52Ser)	SDHB (A52S)	Single nucleotide variant (missense variant)	Gastrointestinal stromal tumor +2 more	GUncertain significance
Select item 2952214	NM_003000.3(SDHB):c.797T>A (p.Ile266Asn)	SDHB (I248N +1 more)	Single nucleotide variant (missense variant)	Gastrointestinal stromal tumor +2 more	GUncertain significance
Select item 2951656	NM_003000.3(SDHB):c.233A>T (p.Lys78Met)	SDHB (K78M)	Single nucleotide variant (missense variant)	Paragangliomas 4 +2 more	GUncertain significance
Select item 2951573	NM_003000.3(SDHB):c.128C>T (p.Ala43Val)	SDHB (A43V)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma +4 more	GUncertain significance
Select item 2951425	NM_003000.3(SDHB):c.756C>T (p.Thr252=)	SDHB	Single nucleotide variant (synonymous variant)	Paragangliomas 4 +2 more	GLikely benign
Select item 2950880	NM_003000.3(SDHB):c.174G>A (p.Met58Ile)	SDHB (M58I)	Single nucleotide variant (missense variant)	Paragangliomas 4 +2 more	GUncertain significance
Select item 2950703	NM_003000.3(SDHB):c.654G>C (p.Trp218Cys)	SDHB (W200C +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GConflicting classifications of pathogenicity
Select item 2950569	NM_003000.3(SDHB):c.424-5C>T	SDHB	Single nucleotide variant (intron variant)	Paragangliomas 4 +2 more	GLikely benign
Select item 2950230	NM_003000.3(SDHB):c.643-14C>A	SDHB	Single nucleotide variant (intron variant)	Paragangliomas 4 +2 more	GLikely benign
Select item 2950080	NM_003000.3(SDHB):c.500A>G (p.Lys167Arg)	SDHB (K167R +1 more)	Single nucleotide variant (missense variant)	Paragangliomas 4 +2 more	GUncertain significance
Select item 2949817	NM_003000.3(SDHB):c.784del (p.Ala262fs)	SDHB (A244fs +1 more)	Deletion (frameshift variant)	Paragangliomas 4 +2 more	GPathogenic
Select item 2949787	NM_003000.3(SDHB):c.286+17T>C	SDHB	Single nucleotide variant (intron variant)	Paragangliomas 4 +2 more	GLikely benign
Select item 2949595	NM_003000.3(SDHB):c.385C>A (p.Pro129Thr)	SDHB (P129T)	Single nucleotide variant (missense variant +1 more)	Paragangliomas 4 +2 more	GUncertain significance
Select item 2949579	NM_003000.3(SDHB):c.146del (p.Pro49fs)	SDHB (P49fs)	Deletion (frameshift variant)	Paragangliomas 4 +2 more	GPathogenic

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