NM_024006.4(VKORC1):c.-1639G>A AND See cases

Germline classification:: Uncertain significance (1 submission)
Review status:: (0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided

Somatic classification of clinical impact:: None
Review status:: (0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided

Somatic classification of oncogenicity:: None
Review status:: (0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided

Record status:: current
Accession:: RCV003993732.1

Allele description [Variation Report for NM_024006.4(VKORC1):c.-1639G>A]

NM_024006.4(VKORC1):c.-1639G>A

Gene:

VKORC1:vitamin K epoxide reductase complex subunit 1 [Gene - OMIM - HGNC]

Variant type:

single nucleotide variant

Cytogenetic location:

16p11.2

Genomic location:

Preferred name:

NM_024006.4(VKORC1):c.-1639G>A

Other names:

VKORC1, -1639G-A (rs9923231); NM_024006.5(VKORC1):c.-1639G>T

HGVS:

NC_000016.10:g.31096368C>T
NG_011564.1:g.3588G>A
LRG_582:g.3588G>A
NC_000016.9:g.31107689C>T
NM_024006.4:c.-1639G>A
c.-1639G>A

Nucleotide change:

-1639G>A

Links:

OMIM: 608547.0006; dbSNP: rs9923231

NCBI 1000 Genomes Browser:

rs9923231

Condition(s)

Name:: See cases [See the Variation display for details]
Identifiers:

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Submission Accession	Submitter	Review Status (Assertion method)	Clinical Significance (Last evaluated)	Origin	Method	Citations
SCV004812937	Department of Pharmacology - Sarajevo Medical School, University Sarajevo School of Science and Technology	no assertion criteria provided	Uncertain significance	germline	case-control	PubMed (1) [See all records that cite this PMID]

Submission Accession

Submitter

Review Status
(Assertion method)

Clinical Significance
(Last evaluated)

Origin

Method

Citations

SCV004812937

Department of Pharmacology - Sarajevo Medical School, University Sarajevo School of Science and Technology

no assertion criteria provided

Uncertain significance

germline

case-control

PubMed (1)
[See all records that cite this PMID]

Help

Summary from all submissions

Ethnicity	Origin	Affected	Individuals	Families	Chromosomes tested	Number Tested	Family history	Method
not provided	germline	no	32	not provided	not provided	32	not provided	case-control
not provided	germline	yes	16	not provided	not provided	16	not provided	case-control

Citations

PubMed

The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen.

Sconce EA, Khan TI, Wynne HA, Avery P, Monkhouse L, King BP, Wood P, Kesteven P, Daly AK, Kamali F.

Blood. 2005 Oct 1;106(7):2329-33. Epub 2005 Jun 9.

PubMed [citation]

PMID:: 15947090

Details of each submission

From Department of Pharmacology - Sarajevo Medical School, University Sarajevo School of Science and Technology, SCV004812937.1

#	Ethnicity	Individuals	Chromosomes Tested	Family History	Method	Citations
1	not provided	1	not provided	not provided	case-control	PubMed (1)
2	not provided	1	not provided	not provided	case-control	PubMed (1)
3	not provided	1	not provided	not provided	case-control	PubMed (1)
4	not provided	1	not provided	not provided	case-control	PubMed (1)
5	not provided	1	not provided	not provided	case-control	PubMed (1)
6	not provided	1	not provided	not provided	case-control	PubMed (1)
7	not provided	1	not provided	not provided	case-control	PubMed (1)
8	not provided	1	not provided	not provided	case-control	PubMed (1)
9	not provided	1	not provided	not provided	case-control	PubMed (1)
10	not provided	1	not provided	not provided	case-control	PubMed (1)
11	not provided	1	not provided	not provided	case-control	PubMed (1)
12	not provided	1	not provided	not provided	case-control	PubMed (1)
13	not provided	1	not provided	not provided	case-control	PubMed (1)
14	not provided	1	not provided	not provided	case-control	PubMed (1)
15	not provided	1	not provided	not provided	case-control	PubMed (1)
16	not provided	1	not provided	not provided	case-control	PubMed (1)
17	not provided	1	not provided	not provided	case-control	PubMed (1)
18	not provided	1	not provided	not provided	case-control	PubMed (1)
19	not provided	1	not provided	not provided	case-control	PubMed (1)
20	not provided	1	not provided	not provided	case-control	PubMed (1)
21	not provided	1	not provided	not provided	case-control	PubMed (1)
22	not provided	1	not provided	not provided	case-control	PubMed (1)
23	not provided	1	not provided	not provided	case-control	PubMed (1)
24	not provided	1	not provided	not provided	case-control	PubMed (1)
25	not provided	1	not provided	not provided	case-control	PubMed (1)
26	not provided	1	not provided	not provided	case-control	PubMed (1)
27	not provided	1	not provided	not provided	case-control	PubMed (1)
28	not provided	1	not provided	not provided	case-control	PubMed (1)
29	not provided	1	not provided	not provided	case-control	PubMed (1)
30	not provided	1	not provided	not provided	case-control	PubMed (1)
31	not provided	1	not provided	not provided	case-control	PubMed (1)
32	not provided	1	not provided	not provided	case-control	PubMed (1)
33	not provided	1	not provided	not provided	case-control	PubMed (1)
34	not provided	1	not provided	not provided	case-control	PubMed (1)
35	not provided	1	not provided	not provided	case-control	PubMed (1)
36	not provided	1	not provided	not provided	case-control	PubMed (1)
37	not provided	1	not provided	not provided	case-control	PubMed (1)
38	not provided	1	not provided	not provided	case-control	PubMed (1)
39	not provided	1	not provided	not provided	case-control	PubMed (1)
40	not provided	1	not provided	not provided	case-control	PubMed (1)
41	not provided	1	not provided	not provided	case-control	PubMed (1)
42	not provided	1	not provided	not provided	case-control	PubMed (1)
43	not provided	1	not provided	not provided	case-control	PubMed (1)
44	not provided	1	not provided	not provided	case-control	PubMed (1)
45	not provided	1	not provided	not provided	case-control	PubMed (1)
46	not provided	1	not provided	not provided	case-control	PubMed (1)
47	not provided	1	not provided	not provided	case-control	PubMed (1)
48	not provided	1	not provided	not provided	case-control	PubMed (1)

Description

It is uncertain if there exists an association between the presence of the variant or A allele, at the VKORC1 -1639G>A locus, and survival from thromboembolism in COVID-19

#	Sample				Method		Observation
#	Origin	Affected	Number tested	Tissue	Purpose	Method	Individuals	Allele frequency	Families	Co-occurrences
1	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
2	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
3	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
4	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
5	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
6	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
7	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
8	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
9	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
10	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
11	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
12	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
13	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
14	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
15	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
16	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
17	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
18	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
19	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
20	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
21	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
22	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
23	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
24	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
25	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
26	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
27	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
28	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
29	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
30	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
31	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
32	germline	no	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
33	germline	yes	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
34	germline	yes	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
35	germline	yes	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
36	germline	yes	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
37	germline	yes	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
38	germline	yes	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
39	germline	yes	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
40	germline	yes	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
41	germline	yes	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
42	germline	yes	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
43	germline	yes	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
44	germline	yes	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
45	germline	yes	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
46	germline	yes	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
47	germline	yes	1	not provided	assert pathogenicity		1	not provided	not provided	not provided
48	germline	yes	1	not provided	assert pathogenicity		1	not provided	not provided	not provided

Last Updated: Nov 24, 2024

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