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Items: 1 to 100 of 203

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
SKI
(G361S)
Single nucleotide variant
(missense variant)
not specified
+2 more
GConflicting classifications of pathogenicity
SKI
(L446F)
Single nucleotide variant
(missense variant)
not provided
+2 more
GUncertain significance
SKI
(S523L)
Single nucleotide variant
(missense variant)
Shprintzen-Goldberg syndrome
+1 more
GLikely benign
TGFB2
(R131* +1 more)
Single nucleotide variant
(nonsense +1 more)
not provided
+3 more
GPathogenic/Likely pathogenic
TGFB2
(V207L +1 more)
Single nucleotide variant
(missense variant +1 more)
Familial thoracic aortic aneurysm and aortic dissection
+5 more
GBenign/Likely benign
TGFB2
Single nucleotide variant
(intron variant)
Familial thoracic aortic aneurysm and aortic dissection
GUncertain significance
TGFB2
(N302fs +1 more)
Duplication
(frameshift variant)
not provided
+3 more
GPathogenic/Likely pathogenic
TGFB2
(C413S +1 more)
Single nucleotide variant
(missense variant +1 more)
Familial thoracic aortic aneurysm and aortic dissection
GUncertain significance
COL3A1
Single nucleotide variant
(intron variant)
Familial thoracic aortic aneurysm and aortic dissection
+2 more
GPathogenic/Likely pathogenic
COL3A1
(A304D)
Single nucleotide variant
(missense variant)
Familial thoracic aortic aneurysm and aortic dissection
GLikely benign
COL3A1
(P517L)
Single nucleotide variant
(missense variant)
not provided
+3 more
GBenign/Likely benign
COL3A1
(R1109Q)
Single nucleotide variant
(missense variant)
Ehlers-Danlos syndrome, type 4
+2 more
GUncertain significance
COL3A1
(K1313R)
Single nucleotide variant
(missense variant)
Ehlers-Danlos syndrome
+6 more
GConflicting classifications of pathogenicity
COL5A2
(D1265G)
Single nucleotide variant
(missense variant)
Ehlers-Danlos syndrome
+5 more
GConflicting classifications of pathogenicity
COL5A2
Single nucleotide variant
(intron variant)
Ehlers-Danlos syndrome, classic type, 1
+6 more
GConflicting classifications of pathogenicity
COL5A2
(P671S)
Single nucleotide variant
(missense variant)
not provided
+4 more
GBenign/Likely benign
COL5A2
(P659L)
Single nucleotide variant
(missense variant)
Ehlers-Danlos syndrome, classic type, 1
+6 more
GConflicting classifications of pathogenicity
COL5A2
(E565Q)
Single nucleotide variant
(missense variant)
Ehlers-Danlos syndrome, classic type, 2
+2 more
GUncertain significance
COL5A2
(G330D)
Single nucleotide variant
(missense variant)
Familial thoracic aortic aneurysm and aortic dissection
GUncertain significance
COL5A2
(R155C)
Single nucleotide variant
(missense variant)
Ehlers-Danlos syndrome, classic type, 2
+3 more
GConflicting classifications of pathogenicity
COL5A2
Single nucleotide variant
(splice donor variant)
Familial thoracic aortic aneurysm and aortic dissection
+2 more
GConflicting classifications of pathogenicity
COL5A2
(E91Q)
Single nucleotide variant
(missense variant)
Familial thoracic aortic aneurysm and aortic dissection
GUncertain significance
TGFBR2
(G351D +8 more)
Single nucleotide variant
(missense variant)
Familial thoracic aortic aneurysm and aortic dissection
+1 more
GLikely pathogenic
TGFBR2
(L386F +8 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GUncertain significance
TGFBR2
(P406L +8 more)
Single nucleotide variant
(missense variant)
Familial thoracic aortic aneurysm and aortic dissection
+1 more
GUncertain significance
TGFBR2
(A426V +8 more)
Single nucleotide variant
(missense variant)
Familial thoracic aortic aneurysm and aortic dissection
GUncertain significance
TGFBR2
(C461Y +8 more)
Single nucleotide variant
(missense variant)
Loeys-Dietz syndrome 2
+1 more
GLikely pathogenic
TGFBR2
(R495* +10 more)
Single nucleotide variant
(nonsense)
Familial thoracic aortic aneurysm and aortic dissection
+5 more
GPathogenic
TGFBR2
(D524N +10 more)
Single nucleotide variant
(missense variant)
Marfan syndrome
+3 more
GPathogenic/Likely pathogenic
TGFBR2
(R528C +10 more)
Single nucleotide variant
(missense variant)
Loeys-Dietz syndrome
+4 more
GPathogenic
OLikely oncogenic
MYLK, MYLK-AS1
(R1816H +6 more)
Single nucleotide variant
(missense variant)
Familial thoracic aortic aneurysm and aortic dissection
+3 more
GConflicting classifications of pathogenicity
MYLK
(A1615V +2 more)
Single nucleotide variant
(missense variant)
Aortic aneurysm, familial thoracic 7
+1 more
GConflicting classifications of pathogenicity
MYLK
(K1533R +2 more)
Single nucleotide variant
(missense variant)
Aortic aneurysm, familial thoracic 7
GUncertain significance
MYLK
(T1597M +2 more)
Single nucleotide variant
(missense variant)
Familial thoracic aortic aneurysm and aortic dissection
+1 more
GUncertain significance
MYLK
(G1360D +2 more)
Single nucleotide variant
(missense variant)
Aortic aneurysm, familial thoracic 7
+1 more
GUncertain significance
MYLK
(V1328M +2 more)
Single nucleotide variant
(missense variant)
Aortic aneurysm, familial thoracic 7
+1 more
GConflicting classifications of pathogenicity
MYLK
(G866S +2 more)
Single nucleotide variant
(missense variant)
Megacystis-microcolon-intestinal hypoperistalsis syndrome 1
+3 more
GUncertain significance
FBN2
Single nucleotide variant
(synonymous variant)
Familial thoracic aortic aneurysm and aortic dissection
GUncertain significance
FBN2
(F2603S)
Single nucleotide variant
(missense variant)
Familial thoracic aortic aneurysm and aortic dissection
+3 more
GConflicting classifications of pathogenicity
FBN2, LOC126807501
(R1054C)
Single nucleotide variant
(missense variant)
Familial thoracic aortic aneurysm and aortic dissection
+1 more
GUncertain significance
FBN2
(A689N)
Indel
(missense variant)
Congenital contractural arachnodactyly
+2 more
GUncertain significance
FBN2
(R654H)
Single nucleotide variant
(missense variant)
Familial thoracic aortic aneurysm and aortic dissection
+2 more
GConflicting classifications of pathogenicity
FBN2
Single nucleotide variant
(intron variant)
Congenital contractural arachnodactyly
+1 more
GConflicting classifications of pathogenicity
FBN2
Deletion
(inframe_deletion)
Congenital contractural arachnodactyly
+1 more
GUncertain significance
FBN2
(T173I)
Single nucleotide variant
(missense variant)
not provided
+5 more
GConflicting classifications of pathogenicity
TGFBR1
(I72L)
Single nucleotide variant
(missense variant)
TGFBR1-related disorder
+4 more
GConflicting classifications of pathogenicity
TGFBR1
(E74D)
Single nucleotide variant
(missense variant)
Familial thoracic aortic aneurysm and aortic dissection
+1 more
GUncertain significance
TGFBR1
Single nucleotide variant
(synonymous variant)
Loeys-Dietz syndrome
+2 more
GConflicting classifications of pathogenicity
TGFBR1
(V134M +1 more)
Single nucleotide variant
(missense variant +1 more)
Familial thoracic aortic aneurysm and aortic dissection
GUncertain significance
TGFBR1
(N160S +1 more)
Single nucleotide variant
(missense variant +1 more)
Loeys-Dietz syndrome 1
+3 more
GUncertain significance
TGFBR1
(S236F +2 more)
Single nucleotide variant
(missense variant)
not specified
+2 more
GConflicting classifications of pathogenicity
TGFBR1
(R240C +2 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GUncertain significance
TGFBR1
(H283del +2 more)
Deletion
(inframe_deletion)
Loeys-Dietz syndrome 1
+2 more
GUncertain significance
TGFBR1
(H285R +2 more)
Single nucleotide variant
(missense variant)
not provided
+2 more
GUncertain significance
TGFBR1
(G312S +2 more)
Single nucleotide variant
(missense variant)
not provided
+4 more
GPathogenic/Likely pathogenic
TGFBR1
(G312D +2 more)
Single nucleotide variant
(missense variant)
Familial thoracic aortic aneurysm and aortic dissection
+2 more
GUncertain significance
TGFBR1
(R482G +2 more)
Single nucleotide variant
(missense variant)
Familial thoracic aortic aneurysm and aortic dissection
GPathogenic
TGFBR1
(R487W +2 more)
Single nucleotide variant
(missense variant)
not provided
+4 more
GPathogenic/Likely pathogenic
COL5A1
(V172F)
Single nucleotide variant
(missense variant)
not specified
+5 more
GConflicting classifications of pathogenicity
COL5A1
(E983K)
Single nucleotide variant
(missense variant)
Ehlers-Danlos syndrome, classic type, 1
+4 more
GConflicting classifications of pathogenicity
COL5A1
(E1199K)
Single nucleotide variant
(missense variant)
not provided
+3 more
GUncertain significance
COL5A1
Single nucleotide variant
(synonymous variant)
not provided
+3 more
GConflicting classifications of pathogenicity
COL5A1
(S1376P)
Single nucleotide variant
(missense variant)
Familial thoracic aortic aneurysm and aortic dissection
GUncertain significance
COL5A1
Single nucleotide variant
(intron variant)
Fibromuscular dysplasia, multifocal
+9 more
GBenign/Likely benign
COL5A1, LOC101448202
(Q1643R)
Single nucleotide variant
(missense variant)
not provided
+1 more
GConflicting classifications of pathogenicity
COL5A1, LOC101448202
(A1784T)
Single nucleotide variant
(missense variant)
Ehlers-Danlos syndrome
+6 more
GConflicting classifications of pathogenicity
NOTCH1
(S2467L)
Single nucleotide variant
(missense variant)
not provided
+2 more
GConflicting classifications of pathogenicity
NOTCH1
(S2141L)
Single nucleotide variant
(missense variant)
Aortic valve disease 1
+2 more
GConflicting classifications of pathogenicity
NOTCH1
(A2069T)
Single nucleotide variant
(missense variant)
Marfan syndrome
+5 more
GConflicting classifications of pathogenicity
NOTCH1
(R1672C)
Single nucleotide variant
(missense variant)
Adams-Oliver syndrome 5
+2 more
GConflicting classifications of pathogenicity
NOTCH1
(S1657R)
Single nucleotide variant
(missense variant)
Adams-Oliver syndrome 5
+2 more
GConflicting classifications of pathogenicity
NOTCH1
(G1360S)
Single nucleotide variant
(missense variant)
Aortic valve disease 1
+3 more
GConflicting classifications of pathogenicity
NOTCH1
(G1353S)
Single nucleotide variant
(missense variant)
Adams-Oliver syndrome 5
+2 more
GConflicting classifications of pathogenicity
NOTCH1
(V1324L)
Single nucleotide variant
(missense variant)
not provided
+3 more
GConflicting classifications of pathogenicity
NOTCH1
Single nucleotide variant
(intron variant)
Familial thoracic aortic aneurysm and aortic dissection
+4 more
GConflicting classifications of pathogenicity
NOTCH1
(R938W)
Single nucleotide variant
(missense variant)
not provided
+2 more
GConflicting classifications of pathogenicity
NOTCH1
(R912W)
Single nucleotide variant
(missense variant)
Familial thoracic aortic aneurysm and aortic dissection
+5 more
GConflicting classifications of pathogenicity
NOTCH1
(G841S)
Single nucleotide variant
(missense variant)
Adams-Oliver syndrome 5
+3 more
GConflicting classifications of pathogenicity
NOTCH1
(N816D)
Single nucleotide variant
(missense variant)
not provided
+3 more
GUncertain significance
NOTCH1
(E694K)
Single nucleotide variant
(missense variant)
not specified
+4 more
GBenign/Likely benign
NOTCH1
(G690R)
Single nucleotide variant
(missense variant)
Familial thoracic aortic aneurysm and aortic dissection
+3 more
GUncertain significance
NOTCH1
(M674T)
Single nucleotide variant
(missense variant)
Aortic valve disease 1
+1 more
GUncertain significance
NOTCH1
(R448*)
Single nucleotide variant
(nonsense)
not provided
+2 more
GPathogenic/Likely pathogenic
NOTCH1
(P407L)
Single nucleotide variant
(missense variant)
not provided
+4 more
GConflicting classifications of pathogenicity; other
PRKG1
(M13I)
Single nucleotide variant
(missense variant)
Aortic aneurysm, familial thoracic 8
+2 more
GLikely benign
PRKG1
(K344R +1 more)
Single nucleotide variant
(missense variant)
Familial thoracic aortic aneurysm and aortic dissection
GUncertain significance
PRKG1
(T460A +1 more)
Single nucleotide variant
(missense variant)
not provided
+2 more
GUncertain significance
ACTA2-AS1, ACTA2
(T326N +3 more)
Single nucleotide variant
(missense variant)
Aortic aneurysm, familial thoracic 6
+5 more
GUncertain significance
ACTA2, ACTA2-AS1
(R258C +2 more)
Single nucleotide variant
(non-coding transcript variant +1 more)
Familial thoracic aortic aneurysm and aortic dissection
+2 more
GPathogenic
ACTA2, ACTA2-AS1
(K240N +2 more)
Single nucleotide variant
(non-coding transcript variant +1 more)
Familial thoracic aortic aneurysm and aortic dissection
+2 more
GConflicting classifications of pathogenicity
ACTA2, ACTA2-AS1
(R212Q +2 more)
Single nucleotide variant
(non-coding transcript variant +1 more)
Aortic aneurysm, familial thoracic 6
+4 more
GPathogenic/Likely pathogenic
ACTA2
(A140V +2 more)
Single nucleotide variant
(missense variant)
not specified
+3 more
GConflicting classifications of pathogenicity
ACTA2
(P72L)
Single nucleotide variant
(missense variant)
Aortic aneurysm, familial thoracic 6
+2 more
GConflicting classifications of pathogenicity
ACTA2
(M49K)
Single nucleotide variant
(missense variant)
Familial thoracic aortic aneurysm and aortic dissection
GUncertain significance
ACTA2
(G48*)
Single nucleotide variant
(nonsense)
Familial thoracic aortic aneurysm and aortic dissection
GUncertain significance
ACTA2
(R39H)
Single nucleotide variant
(missense variant)
Aortic aneurysm, familial thoracic 6
+3 more
GPathogenic/Likely pathogenic
ACTA2
(R39C)
Single nucleotide variant
(missense variant)
See cases
+4 more
GPathogenic/Likely pathogenic
ACTA2
(I36T)
Single nucleotide variant
(missense variant)
Aortic aneurysm, familial thoracic 6
+3 more
GUncertain significance
EFEMP2
(T312A)
Single nucleotide variant
(missense variant +1 more)
not provided
+4 more
GConflicting classifications of pathogenicity
TGFB3
(R300W)
Single nucleotide variant
(missense variant)
Rienhoff syndrome
+2 more
GPathogenic/Likely pathogenic
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