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Items: 82

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
SELENON
(R466W +1 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GPathogenic/Likely pathogenic
PYCR2
(R125Q +1 more)
Single nucleotide variant
(missense variant)
not provided
GConflicting classifications of pathogenicity
BCL11A
(E208fs +8 more)
Deletion
(frameshift variant +1 more)
not provided
GLikely pathogenic
CNGA3
(R481* +1 more)
Single nucleotide variant
(nonsense)
not provided
GPathogenic
SCN1A
(T162I)
Single nucleotide variant
(missense variant +2 more)
Severe myoclonic epilepsy in infancy
+1 more
GPathogenic/Likely pathogenic
WNT10A
(F228I)
Single nucleotide variant
(missense variant)
SchC6pf-Schulz-Passarge syndrome
+7 more
GConflicting classifications of pathogenicity
TRIP12
(Y1090fs +11 more)
Microsatellite
(frameshift variant)
Neurodevelopmental delay
GPathogenic
SETD5
(R308* +1 more)
Single nucleotide variant
(nonsense)
Intellectual disability-facial dysmorphism syndrome due to SETD5 haploinsufficiency
+1 more
GPathogenic/Likely pathogenic
SETD5
(S1188fs +1 more)
Duplication
(frameshift variant)
Intellectual disability-facial dysmorphism syndrome due to SETD5 haploinsufficiency
+2 more
GPathogenic/Likely pathogenic
SLC6A1
(V511M +2 more)
Single nucleotide variant
(missense variant)
not provided
+4 more
GConflicting classifications of pathogenicity
DHX30
(R746C +2 more)
Single nucleotide variant
(missense variant)
Neurodevelopmental disorder with severe motor impairment and absent language
+2 more
GPathogenic/Likely pathogenic
AP2M1
(R170W +2 more)
Single nucleotide variant
(missense variant)
Autism
+4 more
GConflicting classifications of pathogenicity
NSD2
Microsatellite
(splice acceptor variant)
Neurodevelopmental delay
+4 more
GPathogenic
NAA15, NDUFC1
Deletion
(intron variant +1 more)
not provided
GLikely pathogenic
GABRB2
(D125N)
Single nucleotide variant
(missense variant)
Inborn genetic diseases
+1 more
GPathogenic
SYNGAP1, SYNGAP1-AS1
(G391fs)
Deletion
(frameshift variant)
not provided
+2 more
GPathogenic
SYNGAP1, SYNGAP1-AS1
(R967* +1 more)
Single nucleotide variant
(nonsense)
Intellectual disability, autosomal dominant 5
+1 more
GPathogenic
FOXP4
(A501T +2 more)
Single nucleotide variant
(missense variant)
not provided
+8 more
GPathogenic/Likely pathogenic
PHIP
(R110C)
Single nucleotide variant
(missense variant)
not provided
+3 more
GPathogenic/Likely pathogenic
HACE1
(L832del +8 more)
Microsatellite
(inframe_deletion +1 more)
not provided
GUncertain significance
HIVEP2
(R943*)
Single nucleotide variant
(nonsense)
not provided
+1 more
GPathogenic
ARID1B
(Q122* +5 more)
Single nucleotide variant
(nonsense)
not provided
GPathogenic
ACTB
(S348L)
Single nucleotide variant
(missense variant)
Baraitser-Winter syndrome 1
+2 more
GPathogenic/Likely pathogenic
YWHAG
(R132C)
Single nucleotide variant
(missense variant)
not provided
+3 more
GPathogenic/Likely pathogenic
COL1A2
(G913D)
Single nucleotide variant
(missense variant)
Ehlers-Danlos syndrome, classic type, 1
+2 more
GLikely pathogenic
ACTL6B
(G343R)
Single nucleotide variant
(missense variant +1 more)
Intellectual disability
+4 more
GPathogenic/Likely pathogenic
KMT2E
(K961fs)
Deletion
(frameshift variant)
Global developmental delay
+1 more
GPathogenic/Likely pathogenic
KAT6A
(S378*)
Single nucleotide variant
(nonsense)
Autosomal dominant intellectual disability-craniofacial anomalies-cardiac defects syndrome
GPathogenic
AGO2
(R714W)
Single nucleotide variant
(missense variant)
not provided
+1 more
GPathogenic/Likely pathogenic
AGO2
(P602R)
Single nucleotide variant
(missense variant)
Inborn genetic diseases
GUncertain significance
PUF60
Deletion
(inframe_deletion)
not provided
+2 more
GPathogenic/Likely pathogenic
WAC
(R505* +2 more)
Single nucleotide variant
(nonsense)
DeSanto-Shinawi syndrome due to WAC point mutation
+1 more
GPathogenic
HK1
(S433L +6 more)
Single nucleotide variant
(missense variant)
Autism spectrum disorder
+6 more
GPathogenic/Likely pathogenic
BAG3
(P209L)
Single nucleotide variant
(missense variant)
Peripheral neuropathy
+4 more
GPathogenic
SDHD
(D107H +1 more)
Single nucleotide variant
(3 prime UTR variant +2 more)
not provided
GUncertain significance
MPZL2
(Q74*)
Single nucleotide variant
(nonsense)
Hearing loss, autosomal recessive 111
GPathogenic
KMT2A
(R1154W)
Single nucleotide variant
(missense variant)
Wiedemann-Steiner syndrome
+1 more
GPathogenic/Likely pathogenic
ATN1
Microsatellite
(inframe_deletion)
Congenital hypotonia, epilepsy, developmental delay, and digital anomalies
GLikely pathogenic
GRIN2B
(I751T)
Single nucleotide variant
(missense variant)
not provided
+3 more
GPathogenic/Likely pathogenic
KCNJ8
(H47R)
Single nucleotide variant
(missense variant)
not provided
GLikely pathogenic
SOX5
(R558W +5 more)
Single nucleotide variant
(missense variant)
Lamb-Shaffer syndrome
+1 more
GPathogenic/Likely pathogenic
KRAS
(V14I)
Single nucleotide variant
(missense variant)
Noonan syndrome
GPathogenic
CUX2
(E590K +1 more)
Single nucleotide variant
(missense variant)
CUX2-related disorder
+2 more
GPathogenic/Likely pathogenic
SETD1B
(G1392fs)
Deletion
(frameshift variant)
Intellectual developmental disorder with seizures and language delay
+1 more
GPathogenic/Likely pathogenic
GJB2
(G12fs)
Deletion
Nonsyndromic genetic hearing loss
GPathogenic
LOC130009585, UFM1
Deletion
Leukodystrophy, hypomyelinating, 14
+1 more
GPathogenic/Likely pathogenic
NALCN
(S1306N +2 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GUncertain significance
LIG4
(R814* +2 more)
Single nucleotide variant
(nonsense)
prenatal LIG4 syndrome with aqueductal stenosis
+4 more
GPathogenic/Likely pathogenic
LIG4
(R438fs +2 more)
Microsatellite
(frameshift variant)
not provided
+2 more
GPathogenic
LIG4
(G303R +2 more)
Single nucleotide variant
(missense variant)
prenatal LIG4 syndrome with aqueductal stenosis
+2 more
GLikely pathogenic
CHD8
(R243*)
Single nucleotide variant
(nonsense +1 more)
not provided
GPathogenic
BCL11B
(M801fs +3 more)
Microsatellite
(frameshift variant)
not provided
GLikely pathogenic
CPEB1-AS1, AP3B2
(P37fs +3 more)
Deletion
(frameshift variant)
not provided
+1 more
GPathogenic/Likely pathogenic
USP7
(K182E +3 more)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
ANKRD11
(K1464fs)
Microsatellite
(frameshift variant)
KBG syndrome
+2 more
GPathogenic
FANCA
(W1174*)
Single nucleotide variant
(nonsense)
Fanconi anemia
GPathogenic
CHD3
(R1044W +1 more)
Single nucleotide variant
(missense variant)
Snijders Blok-Campeau syndrome
+1 more
GPathogenic/Likely pathogenic
THRA
(E403K)
Single nucleotide variant
(missense variant +1 more)
Congenital nongoitrous hypothyroidism 6
+1 more
GPathogenic
ATP6V0A1
(R741Q +22 more)
Single nucleotide variant
(missense variant)
not provided
+13 more
GPathogenic/Likely pathogenic
COL1A1
(Q1090*)
Single nucleotide variant
(nonsense)
not provided
GPathogenic
PPM1D
(W427*)
Single nucleotide variant
(nonsense)
Intellectual developmental disorder with gastrointestinal difficulties and high pain threshold
+1 more
GPathogenic
TCF4
(A614V +21 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GPathogenic
WDR83, WDR83OS
Deletion
(splice acceptor variant +1 more)
Hypercholanemia, familial
GPathogenic
TRMT1
(R129* +3 more)
Single nucleotide variant
(nonsense)
not provided
GPathogenic/Likely pathogenic
TRMT1
Single nucleotide variant
(intron variant)
not specified
+1 more
GConflicting classifications of pathogenicity
POLD1
(S1073R +1 more)
Single nucleotide variant
(missense variant +1 more)
Intellectual disability
+1 more
GLikely pathogenic
CNOT3
(N276fs)
Microsatellite
(frameshift variant)
not provided
GPathogenic
ADNP
(N832fs)
Microsatellite
(frameshift variant)
not provided
+2 more
GPathogenic
EEF1A2
(D97N)
Single nucleotide variant
(missense variant)
Developmental and epileptic encephalopathy, 33
GUncertain significance
SON
(V1918fs)
Deletion
(frameshift variant +2 more)
See cases
+5 more
GPathogenic/Likely pathogenic
SHANK3
(R1255fs +1 more)
Deletion
(frameshift variant)
See cases
+4 more
GPathogenic
OTC
Single nucleotide variant
(splice donor variant)
Ornithine carbamoyltransferase deficiency
+1 more
GPathogenic
OTC
(S203F)
Single nucleotide variant
(missense variant)
not provided
+1 more
GConflicting classifications of pathogenicity
BCOR
(L1612fs +2 more)
Duplication
(frameshift variant)
not provided
+1 more
GPathogenic
USP9X
(L28fs)
Duplication
(frameshift variant)
Inborn genetic diseases
+1 more
GPathogenic
SMC1A
(Q1073* +1 more)
Single nucleotide variant
(nonsense)
Congenital muscular hypertrophy-cerebral syndrome
GPathogenic
SMC1A
(E243del +1 more)
Deletion
(inframe_deletion)
not provided
GConflicting classifications of pathogenicity
HDAC8
(R166* +1 more)
Single nucleotide variant
(nonsense +1 more)
Inborn genetic diseases
+8 more
GPathogenic
HNRNPH2, RPL36A-HNRNPH2
(R206W)
Single nucleotide variant
(3 prime UTR variant +1 more)
Neurodevelopmental disorder
+6 more
GPathogenic/Likely pathogenic
HNRNPH2, RPL36A-HNRNPH2
(R212S)
Single nucleotide variant
(3 prime UTR variant +1 more)
not provided
GLikely pathogenic
CUL4B
(R388* +3 more)
Single nucleotide variant
(nonsense)
Intellectual disability
+5 more
GPathogenic
AVPR2
(V88M)
Single nucleotide variant
(missense variant)
not provided
GPathogenic
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