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Items: 57

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
ATAD3A
(L77V)
Single nucleotide variant
(missense variant +1 more)
Pontocerebellar hypoplasia, hypotonia, and respiratory insufficiency syndrome, neonatal lethal
+3 more
GConflicting classifications of pathogenicity
ABCA4
(G1961E +1 more)
Single nucleotide variant
(missense variant)
Retinal dystrophy
+12 more
GPathogenic/Likely pathogenic/Pathogenic, low penetrance
GBA1, LOC106627981
(R535H +2 more)
Single nucleotide variant
(missense variant)
Gaucher disease
+9 more
GPathogenic/Likely pathogenic
GBA1, LOC106627981
(N409S +2 more)
Single nucleotide variant
(missense variant)
Gaucher disease perinatal lethal
+12 more
GPathogenic/Likely pathogenic; risk factor
TOR1AIP1
(R321* +1 more)
Single nucleotide variant
(nonsense)
not provided
+1 more
GLikely pathogenic
FANCL
(L214P +3 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GConflicting classifications of pathogenicity
PROKR1
(E119K)
Single nucleotide variant
(missense variant)
not provided
+1 more
GConflicting classifications of pathogenicity
BTD
(R79C +1 more)
Single nucleotide variant
(missense variant)
Biotinidase deficiency
+1 more
GPathogenic/Likely pathogenic
GNRHR
(R262Q)
Single nucleotide variant
(missense variant +1 more)
not provided
+3 more
GPathogenic/Likely pathogenic
GNRHR
(Q106R)
Single nucleotide variant
(missense variant)
Isolated congenital hypogonadotropic hypogonadism
+4 more
GPathogenic/Likely pathogenic
LRBA
(N2727fs +3 more)
Duplication
(frameshift variant)
not provided
+1 more
GPathogenic/Likely pathogenic
LARS1
Single nucleotide variant
(synonymous variant)
not provided
+1 more
GConflicting classifications of pathogenicity
PKHD1
(A1254fs)
Indel
not provided
+2 more
GPathogenic
LAMA2
(S277L)
Single nucleotide variant
(missense variant)
Muscular dystrophy, limb-girdle, autosomal recessive 23
+3 more
GConflicting classifications of pathogenicity
PDE10A
(R182* +2 more)
Single nucleotide variant
(nonsense)
not provided
+2 more
GConflicting classifications of pathogenicity
BRAT1
Duplication
(inframe_insertion +2 more)
Neurodevelopmental disorder with cerebellar atrophy and with or without seizures
+2 more
GConflicting classifications of pathogenicity
SNX10
(R77* +2 more)
Single nucleotide variant
(nonsense +1 more)
Autosomal recessive osteopetrosis 8
+1 more
GPathogenic/Likely pathogenic
LOC126860125, AP1S1
(Q74*)
Single nucleotide variant
(nonsense)
MEDNIK syndrome
+1 more
GPathogenic/Likely pathogenic
AP1S1
(D122fs)
Deletion
(frameshift variant)
MEDNIK syndrome
+1 more
GLikely pathogenic
DNAAF11
(D146H +2 more)
Single nucleotide variant
(missense variant +1 more)
Primary ciliary dyskinesia 19
+2 more
GPathogenic
GPIHBP1
(G175R)
Single nucleotide variant
(missense variant +1 more)
GPIHBP1-related disorder
+3 more
GConflicting classifications of pathogenicity
GNE
(M712T +5 more)
Single nucleotide variant
(missense variant)
not provided
+2 more
GPathogenic
AGTPBP1
(R1000* +3 more)
Single nucleotide variant
(nonsense)
not provided
GPathogenic
SLC34A3
Single nucleotide variant
(synonymous variant)
Autosomal recessive hypophosphatemic bone disease
+1 more
GConflicting classifications of pathogenicity
OTOG
Deletion
(splice donor variant)
not provided
+1 more
GLikely pathogenic
DHCR7
Single nucleotide variant
(splice acceptor variant)
Inborn genetic diseases
+4 more
GPathogenic/Likely pathogenic
DHCR7
(W151*)
Single nucleotide variant
(nonsense)
Inborn genetic diseases
+6 more
GPathogenic/Likely pathogenic
TYR
(R217W)
Single nucleotide variant
(missense variant)
SKIN/HAIR/EYE PIGMENTATION 3, LIGHT/DARK SKIN
+4 more
GConflicting classifications of pathogenicity
TYR
Single nucleotide variant
(intron variant)
Albinism or congenital nystagmus
+10 more
GPathogenic/Likely pathogenic
AMOTL1
(P110L +1 more)
Single nucleotide variant
(missense variant)
Hypertelorism
+6 more
GConflicting classifications of pathogenicity
MARS1
(R618C)
Single nucleotide variant
(missense variant)
Severe early-onset pulmonary alveolar proteinosis due to MARS deficiency
+4 more
GUncertain significance
EXOSC8, LOC130009581
(F5L)
Single nucleotide variant
(missense variant)
Pontocerebellar hypoplasia, type 1C
+2 more
GConflicting classifications of pathogenicity
ATP7B
(I1073T +4 more)
Single nucleotide variant
(missense variant)
Inborn genetic diseases
+2 more
GConflicting classifications of pathogenicity
ATP7B
(R1151C +4 more)
Single nucleotide variant
(missense variant)
ATP7B-related disorder
+2 more
GPathogenic/Likely pathogenic
ATP7B
(E1064A +4 more)
Single nucleotide variant
(missense variant)
not provided
+2 more
GPathogenic/Likely pathogenic
NR2E3
Single nucleotide variant
(splice acceptor variant)
Ocular albinism
+11 more
GPathogenic/Likely pathogenic
NR2E3
(R311Q)
Single nucleotide variant
(missense variant)
not provided
+5 more
GPathogenic
MEFV
(V726A)
Single nucleotide variant
(missense variant +1 more)
Familial Mediterranean fever
+5 more
GPathogenic/Likely pathogenic
LOC126862264, MEFV
Single nucleotide variant
(missense variant +1 more)
Recurrent fever
+24 more
GPathogenic/Likely pathogenic
MEFV
(F479L +1 more)
Single nucleotide variant
(missense variant)
not provided
+4 more
GConflicting classifications of pathogenicity
PAGR1, MVP-DT
(S92G)
Single nucleotide variant
(missense variant)
lethal neurodevelopmental disorder
GLikely pathogenic
ACSF3
(H309fs +1 more)
Duplication
(frameshift variant +1 more)
not provided
+2 more
GConflicting classifications of pathogenicity
ALDH3A2
(W66* +1 more)
Single nucleotide variant
(nonsense)
not provided
+1 more
GPathogenic/Likely pathogenic
GAA
(L239fs)
Deletion
(frameshift variant)
Glycogen storage disease, type II
GPathogenic
ADAT3, SCAMP4
(V144M +1 more)
Single nucleotide variant
(missense variant +1 more)
Intellectual disability-strabismus syndrome
+1 more
GPathogenic/Likely pathogenic
CYP4F22
(F59L)
Single nucleotide variant
(missense variant)
Lamellar ichthyosis
+2 more
GPathogenic/Likely pathogenic
PEPD
Single nucleotide variant
(splice acceptor variant)
Prolidase deficiency
+1 more
GLikely pathogenic
ERCC2
(R354C +1 more)
Single nucleotide variant
(missense variant)
Xeroderma pigmentosum, group D
+2 more
GConflicting classifications of pathogenicity
PNKP
(T323M)
Single nucleotide variant
(missense variant)
not provided
+4 more
GConflicting classifications of pathogenicity
TNNT1
(L192* +1 more)
Insertion
(nonsense)
Nemaline myopathy 5
+1 more
GPathogenic/Likely pathogenic
TNNI3
(R69fs)
Deletion
(frameshift variant)
not specified
+8 more
GConflicting classifications of pathogenicity
CBS
(I278T +1 more)
Single nucleotide variant
(missense variant)
Classic homocystinuria
+7 more
GPathogenic
CRYBA4, CRYBB1
(N58fs)
Deletion
(frameshift variant)
Cataract 17
+2 more
GPathogenic/Likely pathogenic
SGSM3
(E162fs +3 more)
Duplication
(frameshift variant +1 more)
SGSM3-related intellectual disability
+1 more
GLikely pathogenic
KIAA0930
(A325T +1 more)
Single nucleotide variant
(missense variant)
Neurodevelopmental disorder
GLikely pathogenic
KIAA0930
(S324L +1 more)
Single nucleotide variant
(missense variant)
Neurodevelopmental disorder
+1 more
GConflicting classifications of pathogenicity
KIAA0930
(S322L +1 more)
Single nucleotide variant
(missense variant)
Neurodevelopmental disorder
GLikely pathogenic
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