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Items: 1 to 100 of 21146

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
ISG15
(R92H)
Single nucleotide variant
(missense variant)
not provided
+1 more
GUncertain significance
AGRN
(D58N)
Single nucleotide variant
(missense variant)
Congenital myasthenic syndrome 8
GUncertain significance
AGRN
(A163I +1 more)
Indel
(missense variant)
not provided
+1 more
GUncertain significance
AGRN
(R751Q +1 more)
Single nucleotide variant
(missense variant)
not provided
+2 more
GUncertain significance
B3GALT6
(G37E)
Single nucleotide variant
(missense variant)
not provided
+4 more
GConflicting classifications of pathogenicity
B3GALT6
(E105Q)
Single nucleotide variant
(missense variant)
Spondyloepimetaphyseal dysplasia with joint laxity, type 1, with or without fractures
+1 more
GUncertain significance
B3GALT6
(L205V)
Single nucleotide variant
(missense variant)
not provided
+1 more
GUncertain significance
B3GALT6
(D285N)
Single nucleotide variant
(missense variant)
Ehlers-Danlos syndrome, spondylodysplastic type, 2
+4 more
GConflicting classifications of pathogenicity
DVL1
(R222Q)
Single nucleotide variant
(missense variant)
not provided
+1 more
GConflicting classifications of pathogenicity
VWA1
(G25fs)
Microsatellite
(frameshift variant)
Neuronopathy, distal hereditary motor, autosomal recessive 7
+2 more
GPathogenic/Likely pathogenic
ATAD3A
(E466K +2 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GUncertain significance
GNB1
(G74S +1 more)
Single nucleotide variant
(missense variant)
Intellectual disability, autosomal dominant 42
+1 more
GConflicting classifications of pathogenicity
GNB1
(M101V +1 more)
Single nucleotide variant
(missense variant +1 more)
not provided
+1 more
GPathogenic/Likely pathogenic
GNB1
Single nucleotide variant
(intron variant)
Intellectual disability, autosomal dominant 42
+1 more
GConflicting classifications of pathogenicity
GNB1
(K78R)
Single nucleotide variant
(5 prime UTR variant +1 more)
not provided
+3 more
GPathogenic/Likely pathogenic
GNB1
(A60T)
Single nucleotide variant
(missense variant +1 more)
not provided
+1 more
GUncertain significance
SKI
(W710R)
Single nucleotide variant
(missense variant)
not provided
+2 more
GUncertain significance
PEX10
(R331Q +4 more)
Single nucleotide variant
(missense variant +1 more)
Peroxisome biogenesis disorder 6A (Zellweger)
+3 more
GConflicting classifications of pathogenicity
PEX10
Single nucleotide variant
(splice donor variant)
not provided
+3 more
GPathogenic/Likely pathogenic
PEX10
(E299* +4 more)
Single nucleotide variant
(nonsense +1 more)
Peroxisome biogenesis disorder
+3 more
GPathogenic/Likely pathogenic
PEX10
(L297P +4 more)
Single nucleotide variant
(missense variant +1 more)
Peroxisome biogenesis disorder 6A (Zellweger)
+3 more
GConflicting classifications of pathogenicity
PEX10
(L272fs +4 more)
Deletion
(frameshift variant +1 more)
Peroxisome biogenesis disorder
+4 more
GPathogenic
PEX10
(H252fs +4 more)
Deletion
(frameshift variant +1 more)
not provided
+3 more
GPathogenic/Likely pathogenic
PEX10
(L236fs +4 more)
Duplication
(frameshift variant +1 more)
not provided
+4 more
GPathogenic
PEX10
Single nucleotide variant
(splice donor variant)
not provided
+4 more
GPathogenic
PEX10
(L113fs)
Deletion
(frameshift variant +2 more)
not provided
+2 more
GPathogenic/Likely pathogenic
PEX10
(H99fs)
Deletion
(frameshift variant +2 more)
Peroxisome biogenesis disorder 6A (Zellweger)
+2 more
GPathogenic/Likely pathogenic
PEX10
(A2fs)
Deletion
(frameshift variant +2 more)
Peroxisome biogenesis disorder 6A (Zellweger)
+3 more
GPathogenic
CEP104
(S761N)
Single nucleotide variant
(missense variant)
Inborn genetic diseases
+2 more
GUncertain significance
NPHP4
(D1367N +2 more)
Single nucleotide variant
(missense variant +1 more)
Nephronophthisis
+3 more
GUncertain significance
NPHP4
(G1285R +2 more)
Single nucleotide variant
(missense variant +1 more)
not provided
+2 more
GUncertain significance
NPHP4
Single nucleotide variant
(synonymous variant +1 more)
Senior-Loken syndrome 4
+3 more
GConflicting classifications of pathogenicity
NPHP4
(P1204L +2 more)
Single nucleotide variant
(missense variant +1 more)
Nephronophthisis
+3 more
GUncertain significance
NPHP4
(T1122P +2 more)
Single nucleotide variant
(missense variant +1 more)
Nephronophthisis
+5 more
GConflicting classifications of pathogenicity
NPHP4
(E989K +2 more)
Single nucleotide variant
(missense variant +1 more)
Nephronophthisis 4
+3 more
GConflicting classifications of pathogenicity
NPHP4
(R25Q)
Single nucleotide variant
(missense variant +2 more)
Nephronophthisis
+2 more
GConflicting classifications of pathogenicity
PLEKHG5
(T797M +2 more)
Single nucleotide variant
(missense variant)
not provided
+3 more
GUncertain significance
PLEKHG5
(D569N +2 more)
Single nucleotide variant
(missense variant)
not provided
+3 more
GUncertain significance
PLEKHG5
(R332W +2 more)
Single nucleotide variant
(missense variant)
Neuronopathy, distal hereditary motor, autosomal recessive 4
+3 more
GConflicting classifications of pathogenicity
PLEKHG5
(P289S +2 more)
Single nucleotide variant
(missense variant)
Charcot-Marie-Tooth disease recessive intermediate C
+3 more
GUncertain significance
CAMTA1
(V240M +1 more)
Single nucleotide variant
(missense variant)
Cerebellar dysfunction with variable cognitive and behavioral abnormalities
+2 more
GUncertain significance
CAMTA1
(R490Q +1 more)
Single nucleotide variant
(missense variant)
Cerebellar dysfunction with variable cognitive and behavioral abnormalities
+1 more
GConflicting classifications of pathogenicity
CAMTA1, LOC126805603
(R322W +3 more)
Single nucleotide variant
(missense variant +1 more)
Cerebellar dysfunction with variable cognitive and behavioral abnormalities
+2 more
GUncertain significance
CAMTA1
(R1659S +7 more)
Single nucleotide variant
(missense variant +1 more)
Cerebellar dysfunction with variable cognitive and behavioral abnormalities
+2 more
GUncertain significance
RERE
(E779D +1 more)
Single nucleotide variant
(missense variant)
Neurodevelopmental disorder with or without anomalies of the brain, eye, or heart
+2 more
GConflicting classifications of pathogenicity
PIK3CD
(E1021K +2 more)
Single nucleotide variant
(missense variant)
not provided
+5 more
GPathogenic
TARDBP
Single nucleotide variant
(missense variant)
Amyotrophic lateral sclerosis type 10
+4 more
GConflicting classifications of pathogenicity
MTOR
Deletion
(inframe_deletion)
Macrocephaly-intellectual disability-neurodevelopmental disorder-small thorax syndrome
+2 more
GConflicting classifications of pathogenicity
MTOR
(S2215F)
Single nucleotide variant
(missense variant)
Overgrowth syndrome and/or cerebral malformations due to abnormalities in MTOR pathway genes
GPathogenic
MTOR
(E1799K)
Single nucleotide variant
(missense variant)
CEBALID syndrome
+5 more
GPathogenic
MTOR
(A1519T)
Single nucleotide variant
(missense variant)
not provided
+1 more
GConflicting classifications of pathogenicity
MTOR
(K444M +1 more)
Single nucleotide variant
(missense variant)
Macrocephaly-intellectual disability-neurodevelopmental disorder-small thorax syndrome
+2 more
GUncertain significance
MTOR
(D415G)
Single nucleotide variant
(missense variant +1 more)
Macrocephaly-intellectual disability-neurodevelopmental disorder-small thorax syndrome
+1 more
GUncertain significance
MTOR
Single nucleotide variant
(intron variant)
Isolated focal cortical dysplasia type II
+1 more
GConflicting classifications of pathogenicity
C1orf167, MTHFR
(S1275N)
Single nucleotide variant
(missense variant +1 more)
Homocystinuria due to methylene tetrahydrofolate reductase deficiency
+1 more
GConflicting classifications of pathogenicity
MTHFR
(R567* +1 more)
Single nucleotide variant
(nonsense)
Homocystinuria due to methylene tetrahydrofolate reductase deficiency
+2 more
GPathogenic/Likely pathogenic
MTHFR
Single nucleotide variant
(splice donor variant)
Neural tube defects, folate-sensitive
+4 more
GPathogenic/Likely pathogenic
MTHFR
(E514fs +1 more)
Microsatellite
(frameshift variant)
not provided
+5 more
GPathogenic/Likely pathogenic
MTHFR
Single nucleotide variant
(synonymous variant)
Neural tube defects, folate-sensitive
+2 more
GPathogenic
MTHFR
(W500* +1 more)
Single nucleotide variant
(nonsense)
Neural tube defects, folate-sensitive
+1 more
GPathogenic/Likely pathogenic
MTHFR
(W421S +1 more)
Single nucleotide variant
(missense variant)
Neural tube defects, folate-sensitive
+2 more
GLikely pathogenic
MTHFR
(R388C +1 more)
Single nucleotide variant
(missense variant)
Homocystinuria due to methylene tetrahydrofolate reductase deficiency
+2 more
GUncertain significance
MTHFR
(R377C +1 more)
Single nucleotide variant
(missense variant)
Homocystinuria due to methylene tetrahydrofolate reductase deficiency
+2 more
GConflicting classifications of pathogenicity
MTHFR
(R183Q +1 more)
Single nucleotide variant
(missense variant)
not provided
+3 more
GPathogenic/Likely pathogenic
MTHFR
(R157Q +1 more)
Single nucleotide variant
(missense variant)
Homocystinuria due to methylene tetrahydrofolate reductase deficiency
+4 more
GPathogenic/Likely pathogenic
MTHFR
(R109* +1 more)
Single nucleotide variant
(nonsense)
not provided
+2 more
GPathogenic/Likely pathogenic
MTHFR
(R52Q +1 more)
Single nucleotide variant
(missense variant)
not provided
+4 more
GPathogenic/Likely pathogenic
PLOD1
(Q327* +1 more)
Single nucleotide variant
(nonsense)
Ehlers-Danlos syndrome, kyphoscoliotic type 1
+1 more
GPathogenic
PLOD1
(E335D +1 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GUncertain significance
PLOD1
(Y511* +1 more)
Single nucleotide variant
(nonsense)
Familial thoracic aortic aneurysm and aortic dissection
+3 more
GPathogenic
PLOD1
(P553L +1 more)
Single nucleotide variant
(missense variant)
Familial thoracic aortic aneurysm and aortic dissection
+3 more
GUncertain significance
MFN2
(R94W)
Single nucleotide variant
(missense variant)
Inborn genetic diseases
+21 more
GPathogenic
MFN2
(R94Q)
Single nucleotide variant
(missense variant)
not provided
+5 more
GPathogenic
MFN2
(R104W)
Single nucleotide variant
(missense variant)
Charcot-Marie-Tooth disease, axonal, autosomal recessive, type 2a2b;
+7 more
GPathogenic
MFN2
(C281S)
Single nucleotide variant
(missense variant)
Charcot-Marie-Tooth disease, axonal, autosomal recessive, type 2a2b;
+6 more
GConflicting classifications of pathogenicity
MFN2
(R364W)
Single nucleotide variant
(missense variant)
Charcot-Marie-Tooth disease type 2
+3 more
GPathogenic
MFN2
(R663C)
Single nucleotide variant
(missense variant)
Inborn genetic diseases
+4 more
GConflicting classifications of pathogenicity
MFN2
(R707W)
Single nucleotide variant
(missense variant)
not provided
+8 more
GPathogenic/Likely pathogenic
MFN2
(R707Q)
Single nucleotide variant
(missense variant)
Charcot-Marie-Tooth disease type 2A2
+4 more
GUncertain significance
MFN2
(Q754fs)
Duplication
(frameshift variant)
Charcot-Marie-Tooth disease type 2
+2 more
GConflicting classifications of pathogenicity
VPS13D
(N98S)
Single nucleotide variant
(missense variant)
Autosomal recessive cerebellar ataxia-saccadic intrusion syndrome
+1 more
GUncertain significance
VPS13D
(I205T)
Single nucleotide variant
(missense variant)
Autosomal recessive cerebellar ataxia-saccadic intrusion syndrome
+2 more
GUncertain significance
VPS13D
Single nucleotide variant
(intron variant)
Autosomal recessive cerebellar ataxia-saccadic intrusion syndrome
+1 more
GConflicting classifications of pathogenicity
VPS13D
(Y2322C)
Single nucleotide variant
(missense variant)
not provided
+1 more
GUncertain significance
VPS13D
(P2788R)
Single nucleotide variant
(missense variant)
Autosomal recessive cerebellar ataxia-saccadic intrusion syndrome
+2 more
GUncertain significance
VPS13D
(I3028V +1 more)
Single nucleotide variant
(missense variant)
Autosomal recessive cerebellar ataxia-saccadic intrusion syndrome
+1 more
GUncertain significance
VPS13D
(Q3221R +1 more)
Single nucleotide variant
(missense variant)
not provided
+2 more
GUncertain significance
VPS13D
(R3365Q +1 more)
Single nucleotide variant
(missense variant)
Autosomal recessive cerebellar ataxia-saccadic intrusion syndrome
+1 more
GUncertain significance
VPS13D
(D3495Y +1 more)
Single nucleotide variant
(missense variant)
Autosomal recessive cerebellar ataxia-saccadic intrusion syndrome
+1 more
GUncertain significance
CTRC
(G217S)
Single nucleotide variant
(missense variant)
not provided
+1 more
GConflicting classifications of pathogenicity
CTRC
Deletion
(inframe_deletion)
not specified
+2 more
GPathogenic
ATP13A2
(Y1020fs +2 more)
Deletion
(frameshift variant)
Kufor-Rakeb syndrome
+4 more
GPathogenic/Likely pathogenic
ATP13A2
(Q755E +1 more)
Single nucleotide variant
(missense variant)
Kufor-Rakeb syndrome
+4 more
GConflicting classifications of pathogenicity
ATP13A2
(Q635* +1 more)
Single nucleotide variant
(nonsense)
Autosomal recessive spastic paraplegia type 78
+2 more
GPathogenic
ATP13A2
(G217S +1 more)
Single nucleotide variant
(missense variant)
not provided
+2 more
GUncertain significance
ATP13A2
Deletion
(splice acceptor variant)
not provided
+2 more
GConflicting classifications of pathogenicity
ATP13A2
(V89I)
Single nucleotide variant
(missense variant)
Kufor-Rakeb syndrome
+3 more
GUncertain significance
SDHB
(K274E)
Single nucleotide variant
(missense variant)
Hereditary cancer-predisposing syndrome
+5 more
GUncertain significance
SDHB
(M247V)
Single nucleotide variant
(missense variant)
Gastrointestinal stromal tumor
+5 more
GUncertain significance
SDHB
(I246V)
Single nucleotide variant
(missense variant)
Pheochromocytoma
+5 more
GUncertain significance
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