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Items: 1 to 100 of 257

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
NRAS
(Q61H)
Single nucleotide variant
(missense variant)
not provided
+1 more
GConflicting classifications of pathogenicity
NRAS
(Q61L)
Single nucleotide variant
(missense variant)
RASopathy
GUncertain significance
NRAS
(Q61P)
Single nucleotide variant
(missense variant)
not provided
GPathogenic
NRAS
(Q61R)
Single nucleotide variant
(missense variant)
Large congenital melanocytic nevus
+4 more
GPathogenic
OOncogenic
NRAS
(Q61K)
Single nucleotide variant
(missense variant)
Large congenital melanocytic nevus
+3 more
GConflicting classifications of pathogenicity
OOncogenic
NFE2L2
(E63D +2 more)
Single nucleotide variant
(missense variant +1 more)
Neoplasm of uterine cervix
+5 more
GLikely pathogenic
NFE2L2
(E63V +2 more)
Single nucleotide variant
(missense variant +2 more)
Neoplasm of uterine cervix
+5 more
GLikely pathogenic
NFE2L2
(E63K +1 more)
Single nucleotide variant
(synonymous variant +2 more)
Neoplasm of uterine cervix
+6 more
GPathogenic/Likely pathogenic
NFE2L2
(E63Q +2 more)
Single nucleotide variant
(missense variant +1 more)
Neoplasm of uterine cervix
+5 more
GLikely pathogenic
SF3B1
(K666Q)
Single nucleotide variant
(missense variant)
Breast neoplasm
+3 more
GLikely pathogenic
SF3B1
(K666E)
Single nucleotide variant
(missense variant)
Breast neoplasm
+4 more
GLikely pathogenic
IDH1
(R132L)
Single nucleotide variant
(missense variant)
Breast neoplasm
+15 more
GPathogenic/Likely pathogenic
OOncogenic
IDH1
(R132H)
Single nucleotide variant
(missense variant)
Metaphyseal chondromatosis with D-2-hydroxyglutaric aciduria
+4 more
GPathogenic/Likely pathogenic
OOncogenic
IDH1
(R132S)
Single nucleotide variant
(missense variant)
not provided
GPathogenic
IDH1
(R132G)
Single nucleotide variant
(missense variant)
Adenoid cystic carcinoma
+14 more
GPathogenic/Likely pathogenic
IDH1
(R132C)
Single nucleotide variant
(missense variant)
Enchondromatosis
+5 more
GPathogenic/Likely pathogenic
OOncogenic
CNOT9
(S87P)
Single nucleotide variant
(missense variant +1 more)
Gastric adenocarcinoma
+4 more
GLikely pathogenic
CNOT9
(S87C)
Single nucleotide variant
(missense variant +1 more)
Prostate adenocarcinoma
+4 more
GLikely pathogenic
CTNNB1, LOC126806658
(D32N +1 more)
Single nucleotide variant
(missense variant)
Juvenile nasopharyngeal angiofibroma
GPathogenic
CTNNB1, LOC126806658
(D32H +1 more)
Single nucleotide variant
(missense variant)
Neoplasm of uterine cervix
+8 more
GLikely pathogenic
CTNNB1, LOC126806658
(D32Y +1 more)
Single nucleotide variant
(missense variant)
Craniopharyngioma
+11 more
GPathogenic/Likely pathogenic; other
OOncogenic
CTNNB1, LOC126806658
(D32V +1 more)
Single nucleotide variant
(missense variant)
Medulloblastoma
+8 more
GLikely pathogenic
CTNNB1, LOC126806658
(D32A +1 more)
Single nucleotide variant
(missense variant)
Neoplasm of uterine cervix
+8 more
GLikely pathogenic
CTNNB1, LOC126806658
(D32G +1 more)
Single nucleotide variant
(missense variant)
Neoplasm of uterine cervix
+10 more
GPathogenic/Likely pathogenic
CTNNB1, LOC126806658
(S33T +1 more)
Single nucleotide variant
(missense variant)
Carcinoma of esophagus
+10 more
GLikely pathogenic
CTNNB1, LOC126806658
(S33A +1 more)
Single nucleotide variant
(missense variant)
Carcinoma of esophagus
+10 more
GLikely pathogenic
CTNNB1, LOC126806658
(S33P +1 more)
Single nucleotide variant
(missense variant)
Carcinoma of esophagus
+10 more
GLikely pathogenic
CTNNB1, LOC126806658
(S33C +1 more)
Single nucleotide variant
(missense variant)
Carcinoma of esophagus
+14 more
GLikely pathogenic; other
OOncogenic
CTNNB1, LOC126806658
(S33F +1 more)
Single nucleotide variant
(missense variant)
Medulloblastoma
+13 more
GPathogenic/Likely pathogenic; other
CTNNB1, LOC126806658
(S33Y +1 more)
Single nucleotide variant
(missense variant)
Pancreatic adenocarcinoma
+13 more
GPathogenic/Likely pathogenic
CTNNB1, LOC126806658
(G34R +1 more)
Single nucleotide variant
(missense variant)
Gastric adenocarcinoma
+9 more
GLikely pathogenic
CTNNB1, LOC126806658
(G34A +1 more)
Single nucleotide variant
(missense variant)
Gastric adenocarcinoma
+7 more
GLikely pathogenic
CTNNB1, LOC126806658
(G34E +1 more)
Single nucleotide variant
(missense variant)
Medulloblastoma
+9 more
GPathogenic/Likely pathogenic; other
CTNNB1, LOC126806658
(G34V +1 more)
Single nucleotide variant
(missense variant)
Hepatoblastoma
+11 more
GConflicting classifications of pathogenicity
CTNNB1, LOC126806658
(S37A +1 more)
Single nucleotide variant
(missense variant)
Carcinoma of esophagus
+9 more
GLikely pathogenic
CTNNB1, LOC126806658
(S37P +1 more)
Single nucleotide variant
(missense variant)
Neoplasm of stomach
+9 more
GLikely pathogenic
CTNNB1, LOC126806658
(S37Y +1 more)
Single nucleotide variant
(missense variant)
Neoplasm of stomach
+10 more
GPathogenic/Likely pathogenic
CTNNB1, LOC126806658
(S37F +1 more)
Single nucleotide variant
(missense variant)
Melanoma
+11 more
GPathogenic/Likely pathogenic
CTNNB1, LOC126806658
(S37C +1 more)
Single nucleotide variant
(missense variant)
Lung adenocarcinoma
+11 more
GPathogenic/Likely pathogenic
CTNNB1, LOC126806658
(T41A +1 more)
Single nucleotide variant
(missense variant)
Desmoid tumor
GLikely pathogenic
CTNNB1, LOC126806658
(T41N +1 more)
Single nucleotide variant
(missense variant)
Prostate adenocarcinoma
+7 more
GLikely pathogenic
CTNNB1, LOC126806658
(T41I +1 more)
Single nucleotide variant
(missense variant)
Desmoid disease, hereditary
GLikely pathogenic
CTNNB1, LOC126806658
(S45P +1 more)
Single nucleotide variant
(missense variant)
Neoplasm of the large intestine
+11 more
GPathogenic/Likely pathogenic
OOncogenic
CTNNB1, LOC126806658
(S45C +1 more)
Single nucleotide variant
(missense variant)
Prostate adenocarcinoma
+8 more
GLikely pathogenic
CTNNB1, LOC126806658
(S45Y +1 more)
Single nucleotide variant
(missense variant)
Prostate adenocarcinoma
+8 more
GPathogenic/Likely pathogenic
CTNNB1, LOC126806658
(S45F +1 more)
Single nucleotide variant
(missense variant)
Neoplasm of the large intestine
+11 more
GPathogenic/Likely pathogenic; other
PIK3CA
(N345K)
Single nucleotide variant
(missense variant)
Congenital macrodactylia
+14 more
GPathogenic
PIK3CA
(E453Q)
Single nucleotide variant
(missense variant)
Gastric adenocarcinoma
+9 more
GLikely pathogenic
PIK3CA
(E453K)
Single nucleotide variant
(missense variant)
CLOVES syndrome
+5 more
GPathogenic
PIK3CA
(E453D)
Single nucleotide variant
(missense variant)
Gastric adenocarcinoma
+9 more
GLikely pathogenic
PIK3CA
(E542Q)
Single nucleotide variant
(missense variant)
Carcinoma of esophagus
+17 more
GPathogenic/Likely pathogenic
PIK3CA
(E542K)
Single nucleotide variant
(missense variant)
Overgrowth syndrome and/or cerebral malformations due to abnormalities in MTOR pathway genes
+1 more
GPathogenic
OOncogenic
PIK3CA
(E542G)
Single nucleotide variant
(missense variant)
Inborn genetic diseases
+1 more
GLikely pathogenic
PIK3CA
(E542V)
Single nucleotide variant
(missense variant)
Carcinoma of esophagus
+15 more
GLikely pathogenic
PIK3CA
(E542A)
Single nucleotide variant
(missense variant)
Carcinoma of esophagus
+16 more
GPathogenic/Likely pathogenic
PIK3CA
(E545Q)
Single nucleotide variant
(missense variant)
Small cell lung carcinoma
+26 more
GPathogenic/Likely pathogenic; drug response
PIK3CA
(E545K)
Single nucleotide variant
(missense variant)
not provided
+6 more
GPathogenic/Likely pathogenic
OOncogenic
PIK3CA
(E545A)
Single nucleotide variant
(missense variant)
Ovarian neoplasm
GPathogenic
PIK3CA
(E545G)
Single nucleotide variant
(missense variant)
PIK3CA related overgrowth syndrome
GPathogenic
PIK3CA
(E545D)
Single nucleotide variant
(missense variant)
Megalencephaly-capillary malformation-polymicrogyria syndrome
+1 more
GPathogenic/Likely pathogenic
PIK3CA
(H1047Y)
Single nucleotide variant
(missense variant)
not provided
+18 more
GPathogenic
PIK3CA
(H1047L)
Single nucleotide variant
(missense variant)
Inborn genetic diseases
+8 more
GPathogenic
OOncogenic
PIK3CA
(H1047R)
Single nucleotide variant
(missense variant)
Overgrowth syndrome and/or cerebral malformations due to abnormalities in MTOR pathway genes
+1 more
GPathogenic
OOncogenic
PIK3CA
(H1047Q)
Single nucleotide variant
(missense variant)
Pancreatic adenocarcinoma
+21 more
GLikely pathogenic
FGFR1
(K656N +7 more)
Single nucleotide variant
(missense variant)
Lymphoblastic leukemia, acute, with lymphomatous features
+5 more
GLikely pathogenic
FGFR1
(K656E +7 more)
Single nucleotide variant
(missense variant)
Medulloblastoma
+7 more
GConflicting classifications of pathogenicity
CDKN2A
(H83Q +2 more)
Single nucleotide variant
(missense variant +1 more)
Hereditary cancer-predisposing syndrome
GPathogenic
CDKN2A
(H83R +1 more)
Single nucleotide variant
(missense variant +2 more)
Melanoma-pancreatic cancer syndrome
+1 more
GConflicting classifications of pathogenicity
CDKN2A
(A97G +2 more)
Single nucleotide variant
(missense variant +1 more)
Gastric adenocarcinoma
+7 more
GLikely pathogenic
CDKN2A
(A97V +2 more)
Single nucleotide variant
(missense variant +1 more)
Melanoma-pancreatic cancer syndrome
+3 more
GConflicting classifications of pathogenicity
RXRA
(S330Y +2 more)
Single nucleotide variant
(missense variant)
Pancreatic adenocarcinoma
+2 more
GLikely pathogenic
RXRA
(S330F +2 more)
Single nucleotide variant
(missense variant)
Pancreatic adenocarcinoma
+2 more
GLikely pathogenic
RET
(E768D +17 more)
Single nucleotide variant
(missense variant)
Hereditary cancer-predisposing syndrome
+2 more
GPathogenic
HRAS, LRRC56
(Q61P)
Single nucleotide variant
(missense variant +1 more)
Multiple myeloma
+13 more
GLikely pathogenic
HRAS, LRRC56
(Q61L)
Single nucleotide variant
(missense variant +1 more)
Costello syndrome
+1 more
GUncertain significance
OOncogenic
HRAS, LRRC56
(Q61E)
Single nucleotide variant
(missense variant +1 more)
Acute myeloid leukemia
+12 more
GLikely pathogenic
HRAS, LRRC56
(G13A)
Single nucleotide variant
(missense variant +1 more)
Neoplasm of uterine cervix
+9 more
GLikely pathogenic
HRAS, LRRC56
(G13V)
Single nucleotide variant
(missense variant +1 more)
Large congenital melanocytic nevus
+2 more
GPathogenic/Likely pathogenic
HRAS, LRRC56
(G13R)
Single nucleotide variant
(missense variant +1 more)
Noonan syndrome and Noonan-related syndrome
+3 more
GPathogenic/Likely pathogenic
HRAS, LRRC56
(G13C)
Single nucleotide variant
(missense variant +1 more)
Noonan syndrome
GPathogenic
HRAS, LRRC56
(G12A)
Single nucleotide variant
(missense variant +1 more)
Malignant tumor of urinary bladder
+8 more
GPathogenic
HRAS, LRRC56
(G12C)
Single nucleotide variant
(missense variant +1 more)
not provided
+6 more
GPathogenic
HRAS, LRRC56
(G12S)
Single nucleotide variant
(missense variant +1 more)
Costello syndrome
GPathogenic
SF3B2
(H666P)
Single nucleotide variant
(missense variant)
Breast neoplasm
+3 more
GLikely pathogenic
KRAS
(K117N)
Single nucleotide variant
(missense variant)
not provided
GPathogenic
KRAS
(Q61H)
Single nucleotide variant
(missense variant)
Pancreatic adenocarcinoma
+14 more
GPathogenic/Likely pathogenic
AKT1
(E17K)
Single nucleotide variant
(missense variant)
Proteus syndrome
+3 more
GPathogenic
OOncogenic
IDH2
(R120K +2 more)
Single nucleotide variant
(missense variant)
Neoplasm of the large intestine
+5 more
GPathogenic/Likely pathogenic; risk factor
IDH2
(R120M +2 more)
Single nucleotide variant
(missense variant)
Acute myocardial infarction
+5 more
GPathogenic/Likely pathogenic; risk factor
IDH2
(R120G +2 more)
Single nucleotide variant
(missense variant)
Brainstem glioma
+5 more
GLikely pathogenic
OLikely oncogenic
IDH2
(R120W +2 more)
Single nucleotide variant
(missense variant)
Neoplasm of the large intestine
+5 more
GLikely pathogenic; risk factor
CREBBP
(R1446H +1 more)
Single nucleotide variant
(missense variant)
Rubinstein-Taybi syndrome due to CREBBP mutations
GLikely pathogenic
CREBBP
(R1446L +1 more)
Single nucleotide variant
(missense variant)
Malignant melanoma of skin
+11 more
GLikely pathogenic
OLikely oncogenic
CREBBP
(R1446G +1 more)
Single nucleotide variant
(missense variant)
Adenoid cystic carcinoma
+10 more
GLikely pathogenic
CREBBP
(R1446C +1 more)
Single nucleotide variant
(missense variant)
Rubinstein-Taybi syndrome
+2 more
GPathogenic/Likely pathogenic
OOncogenic
TP53
(E154A +3 more)
Single nucleotide variant
(missense variant)
Li-Fraumeni syndrome 1
GLikely pathogenic
TP53
(E154V +3 more)
Single nucleotide variant
(missense variant)
Li-Fraumeni syndrome
GUncertain significance
TP53
(E154G +3 more)
Single nucleotide variant
(missense variant)
Li-Fraumeni syndrome
GUncertain significance
TP53
(E154Q +3 more)
Single nucleotide variant
(missense variant)
Li-Fraumeni syndrome 1
+2 more
GConflicting classifications of pathogenicity
OLikely oncogenic
TP53
(E154K +3 more)
Single nucleotide variant
(missense variant)
Li-Fraumeni syndrome 1
+4 more
GPathogenic/Likely pathogenic
OOncogenic
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