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Items: 92

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
PCSK9
(R237W +5 more)
Single nucleotide variant
(missense variant)
Familial hypercholesterolemia
+6 more
GConflicting classifications of pathogenicity
PCSK9
(R496W +6 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
+7 more
GConflicting classifications of pathogenicity
PCSK9
(N513D +7 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
+4 more
GConflicting classifications of pathogenicity
APOB
(H3570Y)
Single nucleotide variant
(missense variant)
Cardiovascular phenotype
+4 more
GConflicting classifications of pathogenicity
APOB
(Y3560C)
Single nucleotide variant
(missense variant)
Familial hypobetalipoproteinemia 1
+4 more
GConflicting classifications of pathogenicity
APOB
(R3558C)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
+5 more
GConflicting classifications of pathogenicity
APOB
(R3527Q)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
+9 more
GPathogenic/Likely pathogenic
APOB
(R3527W)
Single nucleotide variant
(missense variant)
Homozygous familial hypercholesterolemia
+7 more
GPathogenic/Likely pathogenic
APOB
(L2898P)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, autosomal dominant, type B
+4 more
GConflicting classifications of pathogenicity
APOB
(R1689H)
Single nucleotide variant
(missense variant)
Familial hypobetalipoproteinemia 1
+6 more
GConflicting classifications of pathogenicity
APOB
(T1511I)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
+4 more
GConflicting classifications of pathogenicity
APOB
(C1422Y)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, autosomal dominant, type B
+3 more
GUncertain significance
APOB
(V192I)
Single nucleotide variant
(missense variant)
Cardiovascular phenotype
+4 more
GConflicting classifications of pathogenicity
GHR
(R179C +2 more)
Single nucleotide variant
(missense variant)
not specified
+6 more
GConflicting classifications of pathogenicity
LDLR, LDLR-AS1
Single nucleotide variant
(non-coding transcript variant)
Hypercholesterolemia, familial, 1
+3 more
GConflicting classifications of pathogenicity
LDLR
(W44*)
Single nucleotide variant
(nonsense)
Cardiovascular phenotype
+4 more
GPathogenic/Likely pathogenic
LDLR
(W87G)
Single nucleotide variant
(missense variant +1 more)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
(D90N)
Single nucleotide variant
(missense variant +1 more)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
(S99*)
Single nucleotide variant
(nonsense +1 more)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
(R191H)
Single nucleotide variant
(missense variant +2 more)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
Single nucleotide variant
(synonymous variant +2 more)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
(D118N +1 more)
Single nucleotide variant
(missense variant +1 more)
Cardiovascular phenotype
+3 more
GUncertain significance
LDLR
(D77fs +1 more)
Deletion
(frameshift variant +1 more)
not provided
+2 more
GPathogenic
LDLR
(S177L +1 more)
Single nucleotide variant
(missense variant +1 more)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
(E179* +1 more)
Single nucleotide variant
(nonsense +1 more)
not provided
+1 more
GPathogenic
LDLR
(P181R +1 more)
Single nucleotide variant
(missense variant +1 more)
Hypercholesterolemia, familial, 1
GLikely pathogenic
LDLR
(C197Y +1 more)
Single nucleotide variant
(missense variant +1 more)
Hypercholesterolemia, familial, 1
+4 more
GPathogenic/Likely pathogenic
LDLR
(H211L +1 more)
Single nucleotide variant
(missense variant +1 more)
Familial hypercholesterolemia
+3 more
GConflicting classifications of pathogenicity
LDLR
(G219del +1 more)
Microsatellite
(inframe_deletion +1 more)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
Single nucleotide variant
(synonymous variant +1 more)
Hypercholesterolemia, familial, 1
GUncertain significance
LDLR
(D227E +1 more)
Single nucleotide variant
(missense variant +1 more)
Cardiovascular phenotype
+3 more
GPathogenic/Likely pathogenic
LDLR
(E228* +1 more)
Single nucleotide variant
(nonsense +1 more)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
(E228K +1 more)
Single nucleotide variant
(missense variant +1 more)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
(D266E +2 more)
Single nucleotide variant
(missense variant +1 more)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
(S286R +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
GLikely pathogenic
LDLR
(E288K +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
(R303W +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
GUncertain significance
LDLR
(D307G +3 more)
Single nucleotide variant
(missense variant)
Familial hypercholesterolemia
+2 more
GPathogenic/Likely pathogenic
LDLR
(P309fs +3 more)
Deletion
(frameshift variant)
Familial hypercholesterolemia
+2 more
GPathogenic
LDLR
(K311T +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
GUncertain significance
LDLR
Single nucleotide variant
(splice donor variant)
Hypercholesterolemia, familial, 1
+1 more
GLikely pathogenic
LDLR
(G323C +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
GLikely pathogenic
LDLR
(C338Y +3 more)
Single nucleotide variant
(missense variant)
Familial hypercholesterolemia
+3 more
GPathogenic/Likely pathogenic
LDLR
(L339P +3 more)
Single nucleotide variant
(missense variant)
not provided
+3 more
GConflicting classifications of pathogenicity
LDLR
(D354V +3 more)
Single nucleotide variant
(missense variant)
Cardiovascular phenotype
+3 more
GPathogenic/Likely pathogenic
LDLR
Single nucleotide variant
(intron variant)
Hypercholesterolemia, familial, 1
+4 more
GPathogenic/Likely pathogenic
LDLR
(T413M +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
GLikely pathogenic
LDLR
(R416W +3 more)
Single nucleotide variant
(missense variant)
Homozygous familial hypercholesterolemia
+4 more
GPathogenic/Likely pathogenic
LDLR
(L258R +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
+3 more
GConflicting classifications of pathogenicity
LDLR
(V429M +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
(V436A +3 more)
Single nucleotide variant
(missense variant)
Cardiovascular phenotype
+3 more
GPathogenic/Likely pathogenic
LDLR
(W443C +3 more)
Single nucleotide variant
(missense variant)
Homozygous familial hypercholesterolemia
+4 more
GPathogenic/Likely pathogenic
LDLR, MIR6886
Single nucleotide variant
(non-coding transcript variant +1 more)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
(D472Y +3 more)
Single nucleotide variant
(missense variant)
Homozygous familial hypercholesterolemia
+4 more
GPathogenic/Likely pathogenic
LDLR
(D482N +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
(D492H +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
GLikely pathogenic
LDLR
(G496V +3 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GLikely pathogenic
LDLR
(A501E +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
+2 more
GConflicting classifications of pathogenicity
LDLR
(G516S +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
+3 more
GConflicting classifications of pathogenicity
LDLR
Single nucleotide variant
(intron variant)
Familial hypercholesterolemia
+3 more
GConflicting classifications of pathogenicity
LDLR
(G549D +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
+3 more
GPathogenic/Likely pathogenic
LDLR
(N564H +3 more)
Single nucleotide variant
(missense variant)
not provided
+4 more
GConflicting classifications of pathogenicity
LDLR
Single nucleotide variant
(splice donor variant)
not provided
+1 more
GPathogenic/Likely pathogenic
LDLR
(S404R +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
+1 more
GUncertain significance
LDLR
(L575F +3 more)
Single nucleotide variant
(missense variant)
not provided
+3 more
GConflicting classifications of pathogenicity
LDLR
(G592E +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
(R595Q +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
(W620* +3 more)
Single nucleotide variant
(nonsense)
Hypercholesterolemia, familial, 1
+3 more
GPathogenic
LDLR
(E626K +3 more)
Single nucleotide variant
(missense variant)
Familial hypercholesterolemia
+4 more
GConflicting classifications of pathogenicity
LDLR
(R633H +3 more)
Single nucleotide variant
(missense variant)
Homozygous familial hypercholesterolemia
+4 more
GConflicting classifications of pathogenicity
LDLR
(D638fs +3 more)
Deletion
(frameshift variant)
Cardiovascular phenotype
+4 more
GPathogenic/Likely pathogenic
LDLR
(S648A +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
GUncertain significance
LDLR
(C667Y +2 more)
Single nucleotide variant
(missense variant +1 more)
Hypercholesterolemia, familial, 1
GLikely pathogenic
LDLR
(G508fs +2 more)
Deletion
(frameshift variant +1 more)
Hypercholesterolemia, familial, 1
+2 more
GPathogenic
LDLR
(C681S +2 more)
Single nucleotide variant
(missense variant +1 more)
not provided
+1 more
GPathogenic/Likely pathogenic
LDLR
(C681* +2 more)
Single nucleotide variant
(nonsense +1 more)
Cardiovascular phenotype
+5 more
GPathogenic/Likely pathogenic
LDLR
(A684T +2 more)
Single nucleotide variant
(missense variant +1 more)
Familial hypercholesterolemia
+2 more
GConflicting classifications of pathogenicity
LDLR
(P685L +2 more)
Single nucleotide variant
(missense variant +1 more)
Homozygous familial hypercholesterolemia
+4 more
GPathogenic/Likely pathogenic
LDLR
(P699L +2 more)
Single nucleotide variant
(missense variant +1 more)
Hypercholesterolemia, familial, 1
GUncertain significance
LDLR
(M702I +2 more)
Single nucleotide variant
(missense variant +1 more)
Hypercholesterolemia, familial, 1
GUncertain significance
LDLR
(D707N +2 more)
Single nucleotide variant
(missense variant +1 more)
Hypercholesterolemia, familial, 1
+3 more
GConflicting classifications of pathogenicity
LDLR
(E545* +3 more)
Single nucleotide variant
(nonsense)
LDLR-related disorder
+4 more
GPathogenic/Likely pathogenic
LDLR
(V787M +3 more)
Single nucleotide variant
(missense variant)
Familial hypercholesterolemia
+2 more
GUncertain significance
LDLR
Deletion
(inframe_deletion)
Hypercholesterolemia, familial, 1
+4 more
GConflicting classifications of pathogenicity
LDLR
Single nucleotide variant
(synonymous variant)
Cardiovascular phenotype
+3 more
GConflicting classifications of pathogenicity
LDLR
(V836I +3 more)
Single nucleotide variant
(missense variant)
Familial hypercholesterolemia
+4 more
GConflicting classifications of pathogenicity
LDLR
Single nucleotide variant
(splice donor variant)
Familial hypercholesterolemia
+2 more
GPathogenic/Likely pathogenic
LDLR
Deletion
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
Deletion
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
Deletion
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
Deletion
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
Duplication
Hypercholesterolemia, familial, 1
GPathogenic
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