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Items: 91

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
GNB1
(M101V +1 more)
Single nucleotide variant
(missense variant +1 more)
not provided
+1 more
GPathogenic/Likely pathogenic
GNB1
(K78R)
Single nucleotide variant
(5 prime UTR variant +1 more)
not provided
+3 more
GPathogenic/Likely pathogenic
AHDC1
(S850fs)
Deletion
(frameshift variant)
Hypotonia
+3 more
GPathogenic
DPYD
Single nucleotide variant
(splice donor variant)
tegafur response - Toxicity
+3 more
Gdrug response
H3-3A
(R41C)
Single nucleotide variant
(missense variant)
Bryant-Li-Bhoj neurodevelopmental syndrome 1
+5 more
GPathogenic/Likely pathogenic
H3-3A
(Q56K)
Single nucleotide variant
(missense variant)
Intellectual disability
+4 more
GLikely pathogenic
H3-3A
(G91R)
Single nucleotide variant
(missense variant)
Bryant-Li-Bhoj neurodevelopmental syndrome 1
GUncertain significance
H3-3A
(M121I)
Single nucleotide variant
(missense variant)
not provided
+1 more
GPathogenic
H3-3A
(P122L)
Single nucleotide variant
(missense variant)
not specified
+1 more
GConflicting classifications of pathogenicity
H3-3A
(R129H)
Single nucleotide variant
(missense variant)
Bryant-Li-Bhoj neurodevelopmental syndrome 1
+5 more
GPathogenic/Likely pathogenic
EIF2AK2
(A109V)
Single nucleotide variant
(missense variant)
Leukoencephalopathy, developmental delay, and episodic neurologic regression syndrome
+3 more
GUncertain significance
EIF2AK2
(S97F)
Single nucleotide variant
(missense variant)
Leukoencephalopathy, developmental delay, and episodic neurologic regression syndrome
+3 more
GUncertain significance
MLH1
(N64S)
Single nucleotide variant
(missense variant +2 more)
Muir-Torré syndrome
+10 more
GConflicting classifications of pathogenicity
DHX30
(R782W +2 more)
Single nucleotide variant
(missense variant)
Neurodevelopmental disorder with severe motor impairment and absent language
+1 more
GPathogenic
ACTL6A
(E185Q +1 more)
Single nucleotide variant
(missense variant)
Global developmental delay
+1 more
GUncertain significance
ACTL6A
Single nucleotide variant
(splice donor variant)
Global developmental delay
+1 more
GUncertain significance
SRD5A3
(W19*)
Single nucleotide variant
(nonsense)
SRD5A3-congenital disorder of glycosylation
+3 more
GPathogenic
TBCK
Single nucleotide variant
(splice donor variant)
Hypotonia, infantile, with psychomotor retardation and characteristic facies 3
+2 more
GPathogenic
CYP2U1
(D316V)
Single nucleotide variant
(missense variant)
not provided
+2 more
GPathogenic/Likely pathogenic
NAA15
(H80fs)
Deletion
(frameshift variant)
Inborn genetic diseases
+4 more
GPathogenic/Likely pathogenic
MEA1, PPP2R5D
(E198K +3 more)
Single nucleotide variant
(missense variant)
Neurodevelopmental delay
+6 more
GPathogenic
FBXL4
(R482W)
Single nucleotide variant
(missense variant +1 more)
Leigh syndrome
+3 more
GPathogenic/Likely pathogenic
CDK13
(N842S)
Single nucleotide variant
(missense variant)
Inborn genetic diseases
+4 more
GPathogenic/Likely pathogenic
ARFGEF1-DT, CPA6
(G267R)
Single nucleotide variant
(missense variant)
not provided
+4 more
GConflicting classifications of pathogenicity
CPA6
(Q207E)
Single nucleotide variant
(missense variant)
not specified
+4 more
GConflicting classifications of pathogenicity
GLDC
(R515S)
Single nucleotide variant
(missense variant)
Non-ketotic hyperglycinemia
+5 more
GPathogenic
PTEN
(Y68C +1 more)
Single nucleotide variant
(missense variant +1 more)
See cases
+12 more
GPathogenic/Likely pathogenic
EBF3
(R163Q)
Single nucleotide variant
(missense variant)
Global developmental delay
+8 more
GPathogenic
EBF3
(R163L)
Single nucleotide variant
(missense variant)
Global developmental delay
+5 more
GPathogenic
RAPSN
(L283P)
Single nucleotide variant
(missense variant +1 more)
Global developmental delay
+5 more
GConflicting classifications of pathogenicity
PACS1
(R203W)
Single nucleotide variant
(missense variant)
Aortic root aneurysm
+12 more
GPathogenic/Likely pathogenic
DHCR7
Single nucleotide variant
(splice acceptor variant)
Inborn genetic diseases
+4 more
GPathogenic/Likely pathogenic
C12orf57
(M1V)
Single nucleotide variant
(missense variant +4 more)
Temtamy syndrome
+1 more
GPathogenic/Likely pathogenic
C12orf57
Single nucleotide variant
(5 prime UTR variant +2 more)
Temtamy syndrome
GPathogenic
SCN8A
(F1412S +1 more)
Single nucleotide variant
(missense variant)
Early infantile epileptic encephalopathy with suppression bursts
+5 more
GConflicting classifications of pathogenicity
CEP290, RLIG1
(K2407fs)
Deletion
(frameshift variant +1 more)
Bardet-Biedl syndrome 14
+9 more
GPathogenic/Likely pathogenic
CEP290
(Q1628*)
Single nucleotide variant
(nonsense)
Bardet-Biedl syndrome 14
+13 more
GPathogenic
CEP290
(R504fs)
Microsatellite
(frameshift variant)
not provided
+10 more
GPathogenic/Likely pathogenic
TCTN1
Single nucleotide variant
(splice acceptor variant)
Joubert syndrome 13
GPathogenic
PTPN11
(E139D +1 more)
Single nucleotide variant
(missense variant)
Noonan syndrome
GPathogenic
ISCA2
(G77S)
Single nucleotide variant
(missense variant +1 more)
not provided
+2 more
GPathogenic/Likely pathogenic
HERC2
(A4253T)
Single nucleotide variant
(missense variant)
Developmental delay with autism spectrum disorder and gait instability
+2 more
GUncertain significance
POLG
(R1081Q)
Single nucleotide variant
(missense variant)
Inborn genetic diseases
+13 more
GConflicting classifications of pathogenicity
POLG
(P587L)
Single nucleotide variant
(missense variant)
Mitochondrial disease
+15 more
GConflicting classifications of pathogenicity
POLG
(L424fs)
Microsatellite
(frameshift variant)
Progressive sclerosing poliodystrophy
+4 more
GPathogenic
POLG
(T251I)
Single nucleotide variant
(missense variant)
POLG-Related Spectrum Disorders
+16 more
GConflicting classifications of pathogenicity
LOC126862264, MEFV
Single nucleotide variant
(missense variant +1 more)
Recurrent fever
+24 more
GPathogenic/Likely pathogenic
ANKRD11
(E800fs)
Deletion
(frameshift variant)
KBG syndrome
+3 more
GPathogenic
ANKRD11
(K635fs)
Microsatellite
(frameshift variant)
not provided
+11 more
GPathogenic/Likely pathogenic
GEMIN4
(W818R)
Single nucleotide variant
(missense variant)
Neurodevelopmental disorder with microcephaly, cataracts, and renal abnormalities
GLikely pathogenic
MKS1
(S372del +1 more)
Deletion
(inframe_deletion)
Meckel syndrome, type 1
+9 more
GPathogenic/Likely pathogenic
PTRH2
(Q85P +1 more)
Single nucleotide variant
(missense variant)
Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 1
+1 more
GPathogenic
BPTF
(L330fs)
Deletion
(frameshift variant)
Intellectual disability
GPathogenic
BPTF
(N789fs +1 more)
Deletion
(frameshift variant)
Inborn genetic diseases
GPathogenic
BPTF
(E828fs +1 more)
Duplication
(frameshift variant)
Secondary microcephaly
+3 more
GPathogenic
BPTF
Deletion
(splice donor variant)
Secondary microcephaly
+2 more
GPathogenic
BPTF
(V1739fs +1 more)
Microsatellite
(frameshift variant)
not provided
GPathogenic
BPTF
(A1924T +1 more)
Single nucleotide variant
(missense variant)
Secondary microcephaly
+2 more
GLikely pathogenic
BPTF
(M2853R +1 more)
Single nucleotide variant
(missense variant)
Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies
+3 more
GPathogenic/Likely pathogenic
BPTF
(K2884* +1 more)
Single nucleotide variant
(nonsense)
Secondary microcephaly
+3 more
GPathogenic
TSEN54
(A307S)
Single nucleotide variant
(missense variant)
Global developmental delay
+14 more
GPathogenic
H3-3B
Deletion
(frameshift variant +1 more)
Intellectual disability
+4 more
GLikely pathogenic
H3-3B
(I52N)
Single nucleotide variant
(missense variant)
Bryant-Li-Bhoj neurodevelopmental syndrome 2
+5 more
GPathogenic/Likely pathogenic
H3-3B
(T23K)
Single nucleotide variant
(missense variant)
Intellectual disability
+4 more
GLikely pathogenic
H3-3B
(K10E)
Single nucleotide variant
(missense variant)
Intellectual disability
+4 more
GLikely pathogenic
H3-3B
(R9C)
Single nucleotide variant
(missense variant)
Inborn genetic diseases
GUncertain significance
H3-3B
(A8V)
Single nucleotide variant
(missense variant)
Inborn genetic diseases
+2 more
GConflicting classifications of pathogenicity
SGSH
Deletion
(nonsense +2 more)
Mucopolysaccharidosis, MPS-III-A
+1 more
GPathogenic
SGSH
(S298P)
Single nucleotide variant
(missense variant +1 more)
Sanfilippo syndrome
+2 more
GPathogenic
BPTF
Deletion
Secondary microcephaly
+2 more
GPathogenic
NOL11, BPTF
Deletion
Secondary microcephaly
+2 more
GPathogenic
ADAP2, ATAD5
+10 more
Duplication
Intellectual disability
+2 more
GLikely pathogenic
FZR1
(G287S +1 more)
Single nucleotide variant
(missense variant)
Cerebellar ataxia
+5 more
GConflicting classifications of pathogenicity
CACNA1A
(R1664Q +3 more)
Single nucleotide variant
(missense variant)
not provided
+7 more
GPathogenic/Likely pathogenic
CACNA1A
(I237V)
Single nucleotide variant
(missense variant)
Spinocerebellar ataxia type 6
GUncertain significance
ATP1A3
(E815K +2 more)
Single nucleotide variant
(missense variant)
Inborn genetic diseases
+13 more
GPathogenic
SON
(Q96*)
Single nucleotide variant
(nonsense +2 more)
ZTTK syndrome
+2 more
GPathogenic/Likely pathogenic
SON
(M1025fs)
Duplication
(frameshift variant +2 more)
Global developmental delay
+1 more
GLikely pathogenic
SON
(M1284fs)
Deletion
(frameshift variant +2 more)
not provided
+3 more
GPathogenic/Likely pathogenic
SON
(V1918fs)
Deletion
(frameshift variant +2 more)
See cases
+5 more
GPathogenic/Likely pathogenic
SON
(P106fs +1 more)
Deletion
(frameshift variant +1 more)
Global developmental delay
+1 more
GLikely pathogenic
DYRK1A
(R205* +2 more)
Single nucleotide variant
(nonsense)
not provided
+3 more
GPathogenic
PCNT
(C215Y +1 more)
Single nucleotide variant
(missense variant)
Microcephalic osteodysplastic primordial dwarfism type II
+3 more
GConflicting classifications of pathogenicity
TNRC6B
Single nucleotide variant
(intron variant +1 more)
Autistic behavior
+2 more
GUncertain significance
TNRC6B
(Q1212* +2 more)
Single nucleotide variant
(nonsense)
Autistic behavior
+2 more
GUncertain significance
CLCN4
(G573D +1 more)
Single nucleotide variant
(missense variant)
Intellectual disability, X-linked 49
+1 more
GUncertain significance
WDR45
(R234* +1 more)
Single nucleotide variant
(nonsense)
not provided
+8 more
GPathogenic
SMC1A
(K268del +1 more)
Microsatellite
(inframe_deletion)
Congenital muscular hypertrophy-cerebral syndrome
+6 more
GPathogenic
LAS1L
(R415W +3 more)
Single nucleotide variant
(missense variant +1 more)
Wilson-Turner syndrome
GLikely pathogenic
MED12
(R961W)
Single nucleotide variant
(missense variant)
X-linked intellectual disability with marfanoid habitus
+6 more
GPathogenic/Likely pathogenic
ATP2B3
(K1198N)
Single nucleotide variant
(missense variant +1 more)
X-linked progressive cerebellar ataxia
GLikely pathogenic
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