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Items: 61

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
TGFBR2
Single nucleotide variant
(genic upstream transcript variant +1 more)
Marfan syndrome
+5 more
GConflicting classifications of pathogenicity
TGFBR2
Single nucleotide variant
(genic upstream transcript variant +1 more)
Diabetic retinopathy
+4 more
GUncertain significance/Uncertain risk allele
TGFBR2
Single nucleotide variant
(genic upstream transcript variant +1 more)
Loeys-Dietz syndrome 2
+6 more
GConflicting classifications of pathogenicity
LOC129936399, TGFBR2
Single nucleotide variant
(5 prime UTR variant)
Malignant tumor of esophagus
+5 more
GUncertain significance/Uncertain risk allele
TGFBR2
(M1V)
Single nucleotide variant
(missense variant +1 more)
Diabetic retinopathy
+4 more
GUncertain significance/Uncertain risk allele
TGFBR2
(P26S)
Single nucleotide variant
(missense variant)
Diabetic retinopathy
+5 more
GUncertain significance/Uncertain risk allele
TGFBR2
Single nucleotide variant
(synonymous variant +2 more)
Malignant tumor of esophagus
+6 more
GBenign/Likely benign
TGFBR2
(H56N +1 more)
Single nucleotide variant
(missense variant +1 more)
not provided
+5 more
GConflicting classifications of pathogenicity
TGFBR2
Single nucleotide variant
(intron variant)
Loeys-Dietz syndrome 2
+5 more
GConflicting classifications of pathogenicity
TGFBR2
(T39N +3 more)
Single nucleotide variant
(missense variant)
Loeys-Dietz syndrome 2
+6 more
GUncertain significance/Uncertain risk allele
TGFBR2
(S72N +3 more)
Single nucleotide variant
(missense variant)
Loeys-Dietz syndrome 2
+5 more
GConflicting classifications of pathogenicity
TGFBR2
Single nucleotide variant
(intron variant)
Loeys-Dietz syndrome 2
+4 more
GBenign/Likely benign
TGFBR2
(E139Q +3 more)
Single nucleotide variant
(missense variant)
Familial thoracic aortic aneurysm and aortic dissection
+4 more
GUncertain significance/Uncertain risk allele
TGFBR2
(P129fs +1 more)
Duplication
(frameshift variant)
Colorectal cancer, hereditary nonpolyposis, type 6
+5 more
GUncertain significance
OLikely oncogenic
TGFBR2
(C138G +3 more)
Single nucleotide variant
(missense variant)
Familial thoracic aortic aneurysm and aortic dissection
+6 more
GConflicting classifications of pathogenicity
TGFBR2
(R190G +8 more)
Single nucleotide variant
(missense variant)
Loeys-Dietz syndrome 2
+3 more
GUncertain significance
TGFBR2
(R190H +8 more)
Single nucleotide variant
(missense variant)
Loeys-Dietz syndrome 2
+5 more
GUncertain significance
TGFBR2
(V216I +8 more)
Single nucleotide variant
(missense variant)
not specified
+6 more
GBenign/Likely benign
TGFBR2
(R232Q +8 more)
Single nucleotide variant
(missense variant)
Loeys-Dietz syndrome 2
+6 more
GConflicting classifications of pathogenicity
TGFBR2
(R254C +8 more)
Single nucleotide variant
(missense variant)
Familial thoracic aortic aneurysm and aortic dissection
+4 more
GConflicting classifications of pathogenicity
TGFBR2
(N266S +8 more)
Single nucleotide variant
(missense variant)
Loeys-Dietz syndrome 2
+3 more
GUncertain significance
TGFBR2
(S293L +8 more)
Single nucleotide variant
(missense variant)
Loeys-Dietz syndrome 2
+3 more
GUncertain significance
TGFBR2
(L305F +8 more)
Single nucleotide variant
(missense variant)
Colorectal cancer, hereditary nonpolyposis, type 6
+4 more
GConflicting classifications of pathogenicity
TGFBR2
Single nucleotide variant
(synonymous variant +1 more)
Familial thoracic aortic aneurysm and aortic dissection
+4 more
GBenign/Likely benign
TGFBR2
(A310T +8 more)
Single nucleotide variant
(missense variant)
Familial thoracic aortic aneurysm and aortic dissection
+3 more
GUncertain significance
TGFBR2
(R338Q +8 more)
Single nucleotide variant
(missense variant)
not provided
+5 more
GConflicting classifications of pathogenicity
TGFBR2
(L348V +8 more)
Single nucleotide variant
(missense variant)
not provided
+5 more
GUncertain significance
TGFBR2
(R364W +8 more)
Single nucleotide variant
(missense variant)
not provided
+5 more
GConflicting classifications of pathogenicity
TGFBR2
(V401M +8 more)
Single nucleotide variant
(missense variant)
not provided
+4 more
GUncertain significance
TGFBR2
(I385V +8 more)
Single nucleotide variant
(missense variant)
Cardiovascular phenotype
+5 more
GUncertain significance
TGFBR2
(R428C +8 more)
Single nucleotide variant
(missense variant)
Cardiovascular phenotype
+5 more
GUncertain significance
TGFBR2
(R403H +8 more)
Single nucleotide variant
(missense variant)
Familial thoracic aortic aneurysm and aortic dissection
+6 more
GLikely benign
TGFBR2
(V464A +8 more)
Single nucleotide variant
(missense variant)
Familial thoracic aortic aneurysm and aortic dissection
+3 more
GUncertain significance
TGFBR2
(R479Q +10 more)
Single nucleotide variant
(missense variant)
Colorectal cancer, hereditary nonpolyposis, type 6
+4 more
GUncertain significance
TGFBR2
Single nucleotide variant
(synonymous variant)
Familial thoracic aortic aneurysm and aortic dissection
+5 more
GBenign/Likely benign
TGFBR2
(R495* +10 more)
Single nucleotide variant
(nonsense)
Familial thoracic aortic aneurysm and aortic dissection
+5 more
GPathogenic
TGFBR2
(T516M +10 more)
Single nucleotide variant
(missense variant)
Familial thoracic aortic aneurysm and aortic dissection
+3 more
GUncertain significance
TGFBR2
(S548L +10 more)
Single nucleotide variant
(missense variant)
Loeys-Dietz syndrome 2
+5 more
GUncertain significance
TGFBR2
(G549W +10 more)
Single nucleotide variant
(missense variant)
Loeys-Dietz syndrome 2
+4 more
GUncertain significance
TGFBR2
Single nucleotide variant
(3 prime UTR variant)
Familial thoracic aortic aneurysm and aortic dissection
+5 more
GUncertain significance
WWOX
(P20L)
Single nucleotide variant
(5 prime UTR variant +2 more)
Autosomal recessive spinocerebellar ataxia 12
+5 more
GUncertain significance
WWOX
Single nucleotide variant
(non-coding transcript variant +1 more)
Developmental and epileptic encephalopathy, 28
+3 more
GLikely benign
WWOX
(M114T +1 more)
Single nucleotide variant
(missense variant +2 more)
Autosomal recessive spinocerebellar ataxia 12
+4 more
GUncertain significance
WWOX
(A179S +1 more)
Single nucleotide variant
(missense variant)
Developmental and epileptic encephalopathy, 28
+4 more
GConflicting classifications of pathogenicity
WWOX
(A179T +1 more)
Single nucleotide variant
(missense variant)
Developmental and epileptic encephalopathy, 28
+5 more
GBenign
WWOX
(R188S +1 more)
Single nucleotide variant
(missense variant)
not provided
+4 more
GConflicting classifications of pathogenicity
WWOX
(F197L +1 more)
Single nucleotide variant
(missense variant)
Developmental and epileptic encephalopathy, 28
+4 more
GUncertain significance
WWOX
(Q117P +1 more)
Single nucleotide variant
(missense variant)
Malignant tumor of esophagus
+7 more
GPathogenic/Likely pathogenic
WWOX
(R249H +1 more)
Single nucleotide variant
(missense variant)
not provided
+4 more
GUncertain significance
WWOX
(R264* +1 more)
Single nucleotide variant
(nonsense)
Developmental and epileptic encephalopathy, 1
+4 more
GPathogenic
WWOX
(R196H +1 more)
Single nucleotide variant
(missense variant)
Developmental and epileptic encephalopathy, 1
+4 more
GUncertain significance
WWOX
(S312Y +1 more)
Single nucleotide variant
(missense variant)
Developmental and epileptic encephalopathy, 1
+4 more
GUncertain significance
WWOX
(N330K +1 more)
Single nucleotide variant
(missense variant)
not provided
+4 more
GUncertain significance
WWOX
(P347T +1 more)
Single nucleotide variant
(missense variant)
Developmental and epileptic encephalopathy, 28
+3 more
GUncertain significance
MAF, WWOX
Single nucleotide variant
(synonymous variant)
Developmental and epileptic encephalopathy, 1
+5 more
GBenign/Likely benign
MAF, WWOX
(R408Q +1 more)
Single nucleotide variant
(missense variant)
not provided
+5 more
GUncertain significance
TP53
(R175H +3 more)
Single nucleotide variant
(missense variant)
Li-Fraumeni syndrome
+1 more
GPathogenic
OOncogenic
DCC
Single nucleotide variant
(intron variant)
not provided
+4 more
GBenign
DCC
Single nucleotide variant
(synonymous variant)
not provided
+4 more
GBenign/Likely benign
DCC
Single nucleotide variant
(intron variant)
Colorectal cancer
+4 more
GBenign/Likely benign
DCC
Single nucleotide variant
(synonymous variant)
not provided
+4 more
GBenign/Likely benign
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